A skin antisepsis composition comprising a comprising a (C1-4)alcohol and water in a ratio of at least 60:40, a hydroxycarboxylic acid, a cationic film-forming polymer, and at least one antimicrobial agent; and methods of using the composition are provided.
대표청구항▼
1. A skin antisepsis composition comprising: a vehicle comprising a (C1-C4)alcohol and water in a ratio of at least 60:40;a hydroxycarboxylic acid, wherein the hydroxycarboxylic acid is present in an amount of at least 5 weight percent, based upon the total weight of the composition;a surfactant;a c
1. A skin antisepsis composition comprising: a vehicle comprising a (C1-C4)alcohol and water in a ratio of at least 60:40;a hydroxycarboxylic acid, wherein the hydroxycarboxylic acid is present in an amount of at least 5 weight percent, based upon the total weight of the composition;a surfactant;a cationic film-forming polymer having side chain functional amine groups; andat least one antimicrobial agent; and wherein the cationic film-forming polymer has at least 300 grams and not greater than 3000 grams polymer per equivalent of amine group; and wherein the at least one antimicrobial agent is selected from the group consisting of iodine, triiodide, iodophors, and combinations thereof. 2. The composition of claim 1, wherein the (C1-C4)alcohol is selected from the group consisting of ethanol, isopropanol, n-propanol, and mixtures thereof. 3. The composition of claim 1, wherein the hydroxycarboxylic acid includes one or more compounds represented by the formula: R1(CR2OH)n(CH2)mCOOH wherein: R1 and R2 are each independently H or a (C1-C8)alkyl group (saturated straight, branched, or cyclic group), a (C6-C12)aryl, or a (C6-C12)aralkyl or alkaryl group (saturated straight, branched, or cyclic alkyl group), wherein R1 and R2 may be optionally substituted with one or more carboxylic acid groups; m=0 or 1; and n=1-3, preferably, n=1-2. 4. The composition of claim 1 having a pH of 3 to about 4.5. 5. The composition of claim 1, wherein the hydroxycarboxylic acid is selected from the group consisting of lactic acid, malic acid, citric acid, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, mandelic acid, gluconic acid, tartaric acid, salicylic acid, each of which is unsubstituted or substituted with at least one hydroxyl, phenyl, hydroxyphenyl, alkyl, or halogen group, and combinations thereof. 6. The composition of claim 1, wherein the cationic polymer includes side-chain functional amine groups selected from the group consisting of protonated tertiary amines, quaternary amines, amine oxides, and combinations thereof. 7. The composition of claim 1, wherein the surfactant is selected from the group nonionic, anionic, or amphoteric surfactants. 8. The composition of claim 7, wherein the surfactant is a nonionic surfactant with an HLB value of at least 14. 9. The composition of claim 8, wherein the surfactant is a nonionic surfactant with an HLB value of no greater than 19. 10. The composition of claim 7 wherein the surfactant is an anionic or amphoteric surfactant. 11. The composition of claim 10 wherein the anionic or amphoteric surfactant is selected from the group consisting of sulfonates, sulfates, phosphates, phosphonates, and ammonium sulfonate amphoterics, and mixtures thereof. 12. The composition of claim 11 wherein the anionic surfactant comprises a polyalkoxylate group. 13. The antiseptic composition of claim 7 wherein the surfactant is an amine oxide. 14. The composition of claim 1 further comprising a skin emollient and/or humectant. 15. A method of disinfecting tissue comprising: applying the composition of claim 1 to tissue, wherein the composition is not diluted; andallowing the composition to remain on the tissue for a time sufficient to reduce bacterial load on the tissue. 16. The method of claim 15, further comprising: drying the applied composition to form a film of the dried composition; andplacing a PSA-coated article over the film of the dried composition.
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