Chemical-analysis device integrated with metallic-nanofinger device for chemical sensing
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-021/00
G01N-021/64
G01N-021/65
출원번호
US-0879255
(2010-10-20)
등록번호
US-9279767
(2016-03-08)
국제출원번호
PCT/US2010/053343
(2010-10-20)
§371/§102 date
20130412
(20130412)
국제공개번호
WO2012/054027
(2012-04-26)
발명자
/ 주소
Li, Zhiyong
Williams, R. Stanley
출원인 / 주소
Hewlett-Packard Development Company, L.P.
대리인 / 주소
HP Inc. Patent Department
인용정보
피인용 횟수 :
1인용 특허 :
58
초록▼
A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing. The chemical-analysis device includes a metallic-nanofinger device, and a platform. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofing
A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing. The chemical-analysis device includes a metallic-nanofinger device, and a platform. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule. A morphology of the metallic cap is to generate a shifted plasmonic-resonance peak associated with amplified luminescence from the analyte molecule. A method for using, and a chemical-analysis apparatus including the chemical-analysis device are also provided.
대표청구항▼
1. A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing, said chemical-analysis device comprising: a metallic-nanofinger device for chemical sensing, said metallic-nanofinger device comprising: a substrate; anda plurality of nanofingers coupled with said subst
1. A chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing, said chemical-analysis device comprising: a metallic-nanofinger device for chemical sensing, said metallic-nanofinger device comprising: a substrate; anda plurality of nanofingers coupled with said substrate, a nanofinger of said plurality comprising: a flexible column; anda metallic cap coupled to an apex of said flexible column;wherein at least said nanofinger and a second nanofinger of said plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least said metallic cap and a second metallic cap of respective nanofinger and second nanofinger; andwherein a morphology of said metallic cap is to generate a shifted plasmonic resonance peak associated with amplified luminescence from said analyte molecule; anda platform with which said metallic-nanofinger device is coupled. 2. The chemical-analysis device of claim 1, wherein said metallic-nanofinger device is to produce a change in optical response from said metallic-nanofinger device upon exposing said chemical-analysis device to a liquid, and purging said metallic-nanofinger device of said liquid. 3. The chemical-analysis device of claim 1, said chemical-analysis device further comprising: an enclosure encapsulating said metallic-nanofinger device and to confine said analyte molecule within said enclosure, said enclosure comprising: a micro-fluidic channel to transport a liquid to and from said metallic-nanofinger device disposed within a portion of said micro-fluidic channel. 4. The chemical-analysis device of claim 1, said chemical-analysis device further comprising: an enclosure encapsulating said metallic-nanofinger device and to confine said analyte molecule within said enclosure, said enclosure comprising: a combined micro-fluidic channel and waveguide configured both to transport a liquid to and from said metallic-nanofinger device contained within a portion of said micro-fluidic channel, and to conduct exciting electromagnetic radiation to said metallic-nanofinger device and emitted electromagnetic radiation away from said metallic-nanofinger device. 5. The chemical-analysis device of claim 1, said chemical-analysis device further comprising: an enclosure encapsulating said metallic-nanofinger device and to confine said analyte molecule within said enclosure, said enclosure comprising: an enclosure cover;an enclosure base;enclosure sidewalls attached to said enclosure cover and attached to said enclosure base;an enclosure inlet to admit a liquid into said enclosure; andan enclosure outlet to remove said liquid from said enclosure. 6. The chemical-analysis device of claim 5, wherein a component of said chemical analysis device, which is selected from the group consisting of said enclosure cover, said enclosure base, said enclosure sidewalls, said platform, said substrate, and a combination thereof, is transparent to exciting electromagnetic radiation and to emitted electromagnetic radiation. 7. The chemical-analysis device of claim 1, wherein said plurality of nanofingers coupled with said substrate of said metallic-nanofinger device further comprises: a coating encapsulating said metallic cap; andwherein said coating is to develop a response upon exposure to a liquid. 8. The chemical-analysis device of claim 7, further comprising: a chemical-sensing chip, comprising: said metallic-nanofinger device for chemical sensing, said device further comprising: an array of patches, a patch of said array comprising: said plurality of nanofingers coupled with said substrate; andwherein said coating of said metallic cap in said patch is functionalized with certain probe species to develop a specific response upon exposure to certain targets in said liquid. 9. The chemical-analysis device of claim 8, wherein each patch of said array of patches further comprises: a micro-fluidic channel configured both to confine said analyte molecule within said micro-fluidic channel, and to transport said liquid to and from said metallic-nanofinger device disposed within a portion of said micro-fluidic channel; andwherein said array of patches is configured as a lab-on-chip. 10. The chemical-analysis device of claim 1, wherein said chemical-analysis device further comprises: a test strip. 11. A chemical-analysis apparatus, comprising: a chemical-analysis device integrated with a metallic-nanofinger device for chemical sensing, said chemical-analysis device comprising: a metallic-nanofinger device for chemical sensing, said metallic-nanofinger device comprising: a substrate; anda plurality of nanofingers coupled with said substrate, a nanofinger of said plurality comprising: a flexible column;a metallic cap coupled to an apex of said flexible column; anda coating encapsulating said metallic cap;wherein at least said nanofinger and a second nanofinger of said plurality of nanofingers are to self-arrange into a close-packed configuration with at least one analyte molecule disposed between at least said metallic cap and a second metallic cap of respective nanofinger and second nanofinger;wherein a morphology of said metallic cap is to generate a shifted plasmonic resonance peak associated with amplified luminescence from said analyte molecule; andwherein said coating is to develop a response upon exposure to a liquid; and a platform with which said metallic-nanofinger device is coupled; anda source of exciting electromagnetic radiation to excite said analyte molecule captured by said chemical-analysis device; anda detector to detect emitted electromagnetic radiation that may be emitted from said analyte molecule in response to said exciting electromagnetic radiation. 12. The chemical-analysis apparatus of claim 11, further comprising: an instrument selected from the group consisting of a colorimeter, a reflectometer, a spectrometer, a spectrophotometer, a Raman spectrometer, an optical microscope, and an instrument to accept said chemical-analysis device for optical analysis.
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