A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. T
A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
대표청구항▼
1. A method of forming a medical device comprising the steps of: forming an outer member over a core member, wherein the outer member has an outer surface and an inner surface, the inner surface defining an outer member lumen such that the core member is disposed within the outer member lumen, the o
1. A method of forming a medical device comprising the steps of: forming an outer member over a core member, wherein the outer member has an outer surface and an inner surface, the inner surface defining an outer member lumen such that the core member is disposed within the outer member lumen, the outer and core members forming an elongate composite wire;shaping the composite wire into a pattern by bending the composite wire into a waveform, wherein the pattern defines a stent lumen; forming openings through the outer member; andafter the step of shaping the composite wire into the pattern, exposing the composite wire to an etchant that reacts with the core member to remove the core member from the outer member without adversely affecting the outer member. 2. The method of claim 1, further comprising the step of filling the lumen of the outer member with a therapeutic substance after the core member has been removed. 3. The method of claim 2, wherein the therapeutic substance is selected from the group consisting of antineoplastic, antimitotic, antiinflammatory, antiplatelet, anticoagulant, anti fibrin, antithrombin, antiproliferative, antibiotic, antioxidant, and antiallergic substances as well as combinations thereof. 4. The method of claim 1, wherein the etchant is a liquid chemical that dissolves the core member. 5. The method of claim 4, wherein the outer member is formed from MP35N, the core member is formed from molybdenum, and the etchant is hydrogen peroxide. 6. The method of claim 4, wherein the outer member is formed from a nickel titanium alloy or stainless steel, the core member is formed from gold, and the etchant is potassium triiodide. 7. The method of claim 4, wherein the outer member is formed from an aluminum alloy or stainless steel, the core member is formed from copper, and the etchant is nitric acid. 8. The method of claim 1, wherein the etchant is a gas. 9. The method of claim 8, wherein the outer member is formed from MP35N, the core member is formed from one of tantalum, tungsten, molybdenum, niobium, rhenium, carbon, germanium, and silicon, and the etchant is xenon difluoride. 10. The method of claim 8, wherein the outer member is formed from MP35N, the core member is formed from one of tantalum, tungsten, molybdenum, niobium, rhenium, carbon, germanium, and silicon, and the etchant is bromine trifluoride. 11. The method of claim 8, wherein the outer member is formed from the group consisting of platinum, iridium, titanium, and tantalum, the core member is formed from nickel, and the etchant is carbon monoxide. 12. The method of claim 8, wherein the outer member is formed from stainless steel or nickel-based alloys, the core member is formed from titanium or zirconium, and the etchant is iodine. 13. The method of claim 1, wherein the core member is soluble in the etchant and the outer member is not soluble in the etchant. 14. The method of claim 13, wherein the outer member comprises platinum, the core member is selected from the group consisting of silver, gold, and copper, and the etchant comprises mercury. 15. The method of claim 13, wherein the outer member comprises tungsten, the core member comprises aluminum, and the etchant comprises liquid gallium. 16. The method of claim 1, wherein the step of shaping the composite wire comprises helically wrapping the waveform around a mandrel. 17. A method of forming a medical device comprising the steps of: shaping a composite member into a pattern, the composite member including an outer member formed from MP35N and a core member disposed within a lumen of the outer member, wherein the core member is formed from one of tantalum,tungsten, molybdenum, niobium, rhenium, carbon, germanium, and silicon; forming openings through the outer member; and after the step of shaping the composite member into the pattern, processing the composite member such that the core member is removed from the outer member without adversely affecting the outer member, wherein the step of processing the composite member comprises exposing the composite member to a xenon difluoride gas that reacts with the core member to remove the core member, wherein the xenon difluoride gas does not react with the outer member. 18. The method of claim 17, further comprising the step of filling the lumen of the outer member with a therapeutic substance after the core member has been removed. 19. The method of claim 18, wherein the therapeutic substance is selected from the group consisting of antineoplastic, antimitotic, antiinflammatory, antiplatelet, anticoagulant, anti fibrin, antithrombin, antiproliferative, antibiotic, antioxidant, and antiallergic substances as well as combinations thereof. 20. The method of claim 18, wherein the medical device is a stent.
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