Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-043/42
A61K-031/47
C07D-215/12
C07D-215/14
C07D-215/24
C07H-013/04
C07D-215/32
출원번호
US-0831766
(2013-03-15)
등록번호
US-9284274
(2016-03-15)
발명자
/ 주소
Kashman, Yoel
Flescher, Eliezer
Herzberg, Max
출원인 / 주소
RAMOT at Tel-Aviv University Ltd.
대리인 / 주소
Fuller, Rodney J.
인용정보
피인용 횟수 :
0인용 특허 :
18
초록
The present invention relates to novel jasmonate derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.
대표청구항▼
1. A compound represented by the structure of Formula II: whereinA is COR1;R1 is an unsubstituted or substituted heteroaryloxy;R2 is oxo;R3, R4, R5, R6 and R7 are each hydrogen, wherein the bond between C9 and C10 can be a single or double bond;R15 and R16 are each hydrogen; andn is selected from 0,
1. A compound represented by the structure of Formula II: whereinA is COR1;R1 is an unsubstituted or substituted heteroaryloxy;R2 is oxo;R3, R4, R5, R6 and R7 are each hydrogen, wherein the bond between C9 and C10 can be a single or double bond;R15 and R16 are each hydrogen; andn is selected from 0, 1 and 2;including salts, hydrates, solvates, polymorphs, optical isomers, geometrical isomers, enantiomers, diastereomers, and mixtures thereof. 2. The compound of claim 1, wherein R1 is quinolinyloxy. 3. The compound of claim 1, wherein the bond between C9 and C10 is a double bond. 4. The compound of claim 1, wherein the bond between C9 and C10 is a single bond. 5. The compound of claim 1, which is represented by the structure of Formula 9: 6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and as an active ingredient the compound according to claim 1. 7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, and as an active ingredient the compound according to claim 5. 8. The pharmaceutical composition of claim 6, wherein the composition is in a form suitable for topical administration, oral administration, intravenous administration by injection, administration by inhalation, or administration via a suppository. 9. A method for inhibiting cancer cell proliferation, comprising contacting said cancer cells with a therapeutically effective amount of the compound according to claim 1, wherein the cancer cell is selected from the group consisting of: a prostate cancer cell; a breast cancer cell; a colon cancer cell; a lung cancer cell; a lymphoblastic leukemia cell; a kidney cancer cell; a stomach cancer cell; a melanoma cell; a squamous cell carcinoma cell; a basal cell carcinoma cell; a small cell lung carcinoma cell; a non-small cell lung carcinoma cell; and a large cell lung carcinoma cell. 10. A method for inhibiting cancer cell proliferation, comprising contacting said cancer cells with a therapeutically effective amount of the compound according to claim 9, wherein the cancer cell is selected from the group consisting of: a prostate cancer cell; a breast cancer cell; a colon cancer cell; a lung cancer cell; a lymphoblastic leukemia cell; a kidney cancer cell; a stomach cancer cell; a melanoma cell; a squamous cell carcinoma cell; a basal cell carcinoma cell; a small cell lung carcinoma cell; a non-small cell lung carcinoma cell; and a large cell lung carcinoma cell. 11. A method for treating cancer in a subject, comprising administering to the subject having said cancer a therapeutically effective amount of the compound according to claim 1, wherein the cancer is selected from the group consisting of: prostate cancer; breast cancer; colon cancer; lung cancer; lymphoblastic leukemia; lymphoma; kidney cancer; stomach cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; small cell lung carcinoma; non-small cell lung carcinoma; and large cell lung carcinoma. 12. A method for treating cancer in a subject, comprising administering to the subject having said cancer a therapeutically effective amount of the compound according to claim 5, wherein the cancer is selected from the group consisting of: prostate cancer; breast cancer; colon cancer; lung cancer; lymphoblastic leukemia; lymphoma; kidney cancer; stomach cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; small cell lung carcinoma; non-small cell lung carcinoma; and large cell lung carcinoma. 13. The method of claim 12, wherein the cancer is selected from the group consisting of: breast cancer, prostate cancer, stomach cancer, colon cancer, and kidney cancer. 14. The method of claim 12, wherein the cancer is selected from the group consisting of: small cell lung carcinoma, non-small cell lung carcinoma, and large cell lung carcinoma. 15. The method of claim 12, wherein the cancer is selected from the group consisting of: prostate cancer, breast cancer, and colon cancer. 16. The method of claim 12, wherein the cancer is selected from the group consisting of: melanoma, kidney cancer, stomach cancer and colon cancer. 17. The method of claim 12, wherein the cancer is selected from the group consisting of: squamous cell carcinoma, and basal cell carcinoma.
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