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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0339336 (2014-07-23) |
등록번호 | US-9289449 (2016-03-22) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 623 |
Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and sy
Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.
1. A hydrogel composition, comprising a polysaccharide or derivative thereof having a molecular weight of 1000 Dalton to 80,300 Dalton, a degree of deacetylation of 70% to 99%, and at least two nucleophilic groups, wherein the polysaccharide or derivative thereof is soluble in an aqueous solution;a
1. A hydrogel composition, comprising a polysaccharide or derivative thereof having a molecular weight of 1000 Dalton to 80,300 Dalton, a degree of deacetylation of 70% to 99%, and at least two nucleophilic groups, wherein the polysaccharide or derivative thereof is soluble in an aqueous solution;a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups; anda multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups,wherein the hydrogel composition comprises: a covalent bond between the polysaccharide or derivative thereof and polyethylene glycol polymer;a covalent bond between the polysaccharide or derivative thereof and the multi-armed crosslinker; anda covalent bond between the polyethylene glycol polymer and the multi-armed crosslinker,wherein the polysaccharide or derivative thereof does not act as a cross-linking agent in the hydrogel. 2. The composition of claim 1, wherein the aqueous solution is alkaline and the polysaccharide is soluble in the aqueous solution up to a concentration of 30 mM. 3. A hydrogel composition, comprising a chitosan or derivative thereof having a molecular weight of less than or equal to 5,000 Dalton, a degree of deacetylation of 70% to 99%, and at least two nucleophilic groups, wherein the chitosan or derivative thereof is soluble in an aqueous solution;a multifunctional, multi-armed polyethylene glycol polymer of a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two nucleophilic groups; anda multifunctional, multi-armed crosslinker of polyethylene glycol having a molecular weight of 5,000 Dalton to 30,000 Dalton, and comprising at least two electrophilic groups;wherein the polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis and wherein the hydrogel composition comprises: a covalent bond between the chitosan or derivative thereof and polyethylene glycol polymer;a covalent bond between the chitosan or derivative thereof and the multi-armed crosslinker; anda covalent bond between the polyethylene glycol polymer and the multi-armed crosslinker,wherein the polysaccharide or derivative thereof does not act as a cross-linking agent in the hydrogel. 4. The composition of claim 3, wherein the aqueous solution is alkaline and the chitosan is soluble in the aqueous solution up to a concentration of 30 mM. 5. The composition of claim 1, wherein the polysaccharide substrate is chitosan, carboxymethylcellulose, carboxymethylchitosan or a derivative thereof. 6. The composition of claim 1, wherein the multifunctional, multi-armed crosslinker comprises an aldehyde. 7. The composition of claim 1, wherein the multifunctional, multi-armed crosslinker comprises a glutaraldehyde. 8. The composition of claim 1, wherein the multifunctional, multi-armed crosslinker comprises a heat treated glutaraldehyde. 9. The composition of claim 1, further comprising one or more of a thickening agent, foaming agent, biologically active agent, pharmaceutically active agent, visualization agent and radiopaque agent. 10. The composition of claim 1, wherein the ratio of multifunctional, multi-armed polyethylene glycol polymer to polysaccharide derivative is from 5:1 to 10:1 by mass. 11. The composition of claim 1, wherein the multifunctional, multi-armed polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis. 12. The composition of claim 3, wherein the chitosan derivative is carboxymethylchitosan. 13. The composition of claim 3, wherein the multifunctional, multi-armed crosslinker comprises an aldehyde. 14. The composition of claim 3, wherein the multifunctional, multi-armed crosslinker comprises a glutaraldehyde. 15. The composition of claim 3, wherein the multifunctional, multi-armed crosslinker comprises a heat treated glutaraldehyde. 16. The composition of claim 3, further comprising one or more of a thickening agent, foaming agent, biologically active agent, pharmaceutically active agent, visualization agent and radiopaque agent. 17. The composition of claim 3, wherein the ratio of multifunctional, multi-armed polyethylene glycol polymer to polysaccharide derivative is from 5:1 to 10:1 by mass. 18. The composition of claim 3, wherein the multifunctional, multi-armed polyethylene glycol polymer comprises ester groups to provide for degradation via hydrolysis.
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