$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Rapid detection of replicating cells

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12M-001/00
  • C12M-003/00
  • B82Y-020/00
  • C12Q-001/04
  • C12Q-001/18
  • G01N-033/50
  • G01N-033/569
  • G01N-033/58
  • B82Y-005/00
  • B82Y-010/00
  • G01N-015/14
  • G01N-021/64
출원번호 US-0551917 (2009-09-01)
등록번호 US-9290382 (2016-03-22)
발명자 / 주소
  • Straus, Don
출원인 / 주소
  • Rapid Micro Biosystems
대리인 / 주소
    Clark & Elbing LLP
인용정보 피인용 횟수 : 10  인용 특허 : 119

초록

The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the

대표청구항

1. An instrument for detecting microcolonies of target cells in a sample, said instrument comprising: (a) a photoelectric array detector having associated optics to detect a detection area having at least one dimension that is ≧1 cm without magnifying said detection area by more than 5-fold and an o

이 특허에 인용된 특허 (119)

  1. Yguerabide Juan ; Yguerabide Evangelina E. ; Kohne David E. ; Jackson Jeffrey T., Analyte assay using particulate labels.
  2. Elings, Virgil B.; Nicoli, David F., Apparatus and method for homogeneous immunoassay.
  3. Chan, Anthony; Rocco, Richard M., Apparatus and method for the measurement of cells in biological samples.
  4. Terstappen, Leon W. M. M.; Rao, Galla C., Apparatus and methods for capture and analysis of particulate entities.
  5. Drocourt Jean-Louis,FRX ; Desfetes Patrick,FRX ; Sanghera Jaspal,GBX, Apparatus for rapid and ultrasensitive detection and counting of microorganisms by fluorescence.
  6. Applegate Dawn Orton ; Applegate Mark ; Baumgartner Mark ; Bennett John W. ; Danssaert John ; Hardin Robert ; Laiterman Lee ; Schramm Fred ; Tolbert William R., Apparatus for the growth and packaging of three dimensional tissue cultures.
  7. Verlinden Bartholomeus (Tongeren BEX) Van den Bergen Patrick (Berchem BEX), Apparatus for the wet processing of photographic sheet material.
  8. Rosenthal Murray A. (Copley OH) Simkins Ronald A. (Wooster OH) Akhaury Ranjan (Akron OH), Assay for enzyme activity from a red blood sample using a direct microfluorometric assay.
  9. McConnell Harden M. (Stanford CA), Assay for ligands.
  10. Mortensen Richard B. (Menlo Park CA) Tom Henry K. (La Honda CA), Assay having improved dose response curve.
  11. Krejcarek Gary E. ; Mach Patrick A. ; Morgan Scott D. ; Turgeon Thomas A., Automated incubating and imaging system for a disposable microorganism culturing device and method of use.
  12. Forrest Gordon C. (Chelmsford GB2) Jay Ronald F. (New Malden GB2) Clements John A. (Wallington GB2), Automatic apparatus and method for the assay of fluid samples.
  13. Cubbage Michael L. (Houston TX) Ju Shyh C. (Flowermound TX) Prashad Nagindra (Houston TX) Weber William D. (Bellaire TX) Bresser Joel (Bellaire TX), Background-reducing compounds for probe-mediated fluorimetric flow cytometric assays.
  14. Muller Uwe Richard ; Che Diping ; Bao Yijia, Biological assays for analyte detection.
  15. Taniguchi Nobuyuki (Nishinomiya JPX) Kudo Yoshinobu (Osaka JPX) Inoue Manabu (Kobe JPX) Iwata Michihiro (Sakai JPX) Wada Shigeru (Kishiwada JPX) Ootsuka Hiroshi (Sakai JPX) Yokoyama Shinichi (Kyoto J, Camera having a pseudo format.
  16. Rotman M. Boris, Cell proliferation-based amplified detection of analytes.
  17. Matner Richard R. (St. Paul MN), Colony blotting method and device.
  18. Mansour James D. (Raleigh NC) Schulte Thomas H. (Cary NC) Neece Vernon R. (Durham NC), Composition and method for rapid detection of microorganisms in clinical samples.
  19. Lemonnier Jean (Le Vesinet FRX), Container for micro-organism culture media.
  20. Nelson Robert L. (Bloomington MN) Crandall Michael D. (Woodbury MN) Ramos Mary S. (Minneapolis MN), Culture media device and method of use.
  21. Smith Jerry W. (Ann Arbor MI) Sullivan Nadine M. (Ann Arbor MI), Culture media package.
  22. Bogart Gregory R. (Berthoud CO), Detection of an analyte by fluorescence using a thin film optical device.
  23. Rousseau, Alain; Canton, Michel, Device, method and apparatus for implementing the method, for dosing at least a particular constituent in a product sample.
  24. Lowe, Christopher R.; Earley, Fergus G. P., Diagnostic device incorporating a biochemical ligand.
  25. Giaever ; Ivar, Diagnostic method employing a mixture of normally separable protein-coated particles.
  26. Peter Ramm CA; Gang Sun CA, Digital imaging system for assays in well plates, gels and blots.
  27. Hermann ; Jr. ; William J., Disposable laboratory device for transfer of fluids to a centrifugal analyzer head.
  28. Hansen Paul E. (St. Paul MN) Nelson Robert L. (St. Paul MN), Dry culture media.
  29. Nelis Jozef Constantia Frans Hans,BEX, Enzymatic method for detecting coliform bacteria or E. coli.
  30. Jeffrey Kane, Filtration assembly and culture device.
  31. Banes Albert J., Flexible bottom culture plate for applying mechanical load to cell cultures.
  32. Sasamoto Kazumi (Kumamoto JPX) Horiguchi Daikichi (Kumamoto JPX) Nobuhara Masahiro (Tokyo JPX) Mochizuki Hiroshi (Tokyo JPX), Fluorescent compound, complex, reagent, and specific binding assay employing said reagent.
  33. Kain Robert C. (San Jose CA), Fluoresecence imaging system.
  34. Luotola Juhani E. I. (Espoo FIX) Harjunmaa Hannu (Espoo FIX), Fluorimetric immunological assay with magnetic particles.
  35. Mehra Ravinder C. (Fairport NY) Relyea Robert G. (Canandaigua NY) Baird Peter K. (Fairport NY), Frangible bonded disposable filtration unit with recoverable filter.
  36. Rushbrooke John (Girton GB2) Lyons Adrian (Turnbridge Wells GB2) Tomkins Patricia (Turnbridge Wells GB2) Ansorge Richard (Cambridge GB2), High sensitivity optical imaging apparatus.
  37. Ravkin Ilya, Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images.
  38. Cartlidge, Andrew G.; Fein, Howard, Imaging system and methodology employing reciprocal space optical design.
  39. Rosenstein Robert (Ellicott City MD), Immuno-agglutination particle suspensions.
  40. Niiyama Yasushi,JPX ; Uchida Hiroyasu,JPX ; Tao Ryuji,JPX, Immunoassay method and analyzer using magnetic particles.
  41. Schwarzberg Moshe (Hastings-on-Hudson NY) Dayal Santosh (Fair Lawn NJ), Immunoassay of free substances in biological fluids.
  42. Kumar Amit (Sacramento CA) Kharadia Shanta (Santa Clara CA) Piani Marcos (Redwood City CA) Deshpande Sudhir (Santa Clara CA) Rocco Richard (Sunnyvale CA), Immunoassays in capillaries.
  43. Gross ; Stanley Joseph, Immunochemical assay method.
  44. Luotola Juhani E. I. (Espoo FIX) Harjunmaa Hannu (Espoo FIX), Immunological assay method using magnetic particles.
  45. Hara, Akikuni; Asano, Toshimitsu; Torai, Yoshiaki; Omi, Akihiro, Inspection method for microorganisms and the like, and unit therefor.
  46. Che Diping, Large-field fluorescence imaging apparatus.
  47. Fujiwara Koichi (Mito JPX) Noda Juichi (Mito JPX) Misutani Hiroko (Tokyo JPX) Mizutani ; deceased Hiromichi (late of Tokyo JPX by Hiroko Mizutani ; legal representative), Laser magnetic immunoassay method and apparatus thereof.
  48. Pham Andrew A. ; Coassin Peter J. ; Harootunian Alec Tate ; Stylli Harry ; Tsien Roger Y., Low fluorescence assay platforms and related methods for drug discovery.
  49. Park Han-Oh,KRX ; Kim Jae-Jong,KRX, Lyophilized reagent for polymerase chain reaction.
  50. Matte Claude (Paris FRX) Muller Anne (Gif/Yvette FRX), Magnetic device for immunological analysis of a solid phase.
  51. Davies George E. (Macclesfield UT GB2) Janata Jiri (Salt Lake City UT), Magnetic particles for immunoassay.
  52. Li May K. (Framingham MA) Kessler Jack (Ashland MA) Bach David T. (Westborough MA), Magnetic separation device and methods for use in heterogeneous assays.
  53. Saxholm Rolf (Box 3 1362 Billingstad NO), Magnetically responsive, biologically active substance and associated methods and apparatus.
  54. Yen Shiao-Ping S. (Altadena CA) Rembaum Alan (Altadena CA) Molday Robert S. (Vancouver CAX), Metal containing polymeric functional microspheres.
  55. Hansen, Frans Ejner Rvan; Glensbjerg, Martin; Arnvidarson, Borkur; Jeppesen, Jesper Myron, Method and a system for determination of particles in a liquid sample.
  56. Hansen, Frans Ejner Rvan; Glensbjerg, Martin; Arnvidarson, Borkur; Jeppesen, Jesper Myron, Method and a system for determination of particles in a liquid sample.
  57. Hansen,Frans; Glensbjerg,Martin; Arnvidarson,Borkur; Jeppesen,Jesper Myron, Method and a system for determination of particles in a liquid sample.
  58. Bisconte Jean-Claude,FRX, Method and apparatus for counting cells and microorganisms, particularly in food and biological fluids.
  59. Nelson Robert L. (Bloomington MN) Hansen Paul E.L. (Lake Elmo MN), Method and apparatus for culturing with microbiological dry culture medium.
  60. Braier Robert A. (Woodbury MN) Morgan Scott D. (Cottage Grove MN), Method and apparatus for detecting and identifying microbial colonies.
  61. Bisconte Jean-Claude (Briis-sous-Forges FRX), Method and apparatus for filtering a plurality of samples through a filter with indexing of the filter.
  62. Leland Jonathan K. ; Shah Haresh P. ; Kenten John H. ; Goodman Jack E. ; Lowke George E. ; Namba Yuzaburo,JPX ; Blackburn Gary F. ; Massey Richard J., Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets.
  63. Lemonnier Jean (Le Vesinet FRX), Method and apparatus for microbiological testing of liquids.
  64. Miles Laughton E. (Stanford CA) Rogers ; Jr. Arthur H. (Los Altos CA) Rogers Charles H. (Duxbury MA), Method and apparatus for performing assays.
  65. Schroeder Kirk (Ann Arbor MI) Neagle Brad (Ann Arbor MI), Method and apparatus for quantitative fluorescence measurements.
  66. Powers Linda, Method and apparatus for sensing the presence of microbes.
  67. Rocco Richard M., Method and compound for detecting low levels of microorganisms.
  68. Alfano Robert R. (3777 Independence Ave. Bronx NY 10463), Method and device for detecting biological molecules and/or microorganisms within a desired area or space.
  69. Fodor Stephen P. A. ; Solas Dennis W. ; Dower William J., Method for comparing copy number of nucleic acid sequences.
  70. Stephen C. Wardlaw ; Robert A. Levine, Method for determining the effects of a growth-altering agent on a microbial colony.
  71. Morgan Scott D. (Cottage Grove MN), Method for rapid quantification of microorganism growth.
  72. Starzl Timothy W. ; Nunnery David W. ; Robinson MaryBeth ; Hanlin H. John, Method for specific substance and molecule detection.
  73. King Chester F. ; Hallowitz Robert A., Method of and apparatus for automating detection of microorganisms.
  74. Lindmo Tore (Kolbotn NOX), Method of assay.
  75. Seto Susumu,JPX, Method of determining a viable count using a hydrophobic membrane.
  76. Kawakami Masaya (Sagamihara JPX) Seto Susumu (Yokohama JPX) Tei Seiken (Yokohama JPX), Method of determining viable microbial cell count.
  77. Holian John (Chalfont St. Giles GB2) Edwards John C. (Great Missenden GB2) Martin John K. (Wendover GB2) Charles Stephen A. (Great Missenden GB2), Method of performing assay for analyte in liquid medium.
  78. Wang Chia-Gee (Millwood NY), Method of tagged immunoassay.
  79. Hargreaves William R., Methods and devices for conducting specific binding assays.
  80. Malecki, George J., Methods and means of determining microorganism population.
  81. Weng, Yu-Shi; Shih, Ming-Cheng; Gau, Rung-Jiun, Micro device for cell culture.
  82. Schwartz Abraham (Hato Rey PR), Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbead.
  83. Chandler Mark B. ; Chandler Don J., Microparticles attached to nanoparticles labeled with flourescent dye.
  84. Bisconte, Jean-Claude, Microscope stage for rapid and indexed analysis of filters and other media carrying multiple samples, and a method of analyzing such samples using said stage.
  85. Kapur,Ravi; Giuliano,Kenneth, Miniaturized cell array methods and apparatus for cell-based screening.
  86. Bisconte Jean-Claude (Briis-Sous-Forges FRX), Modular device for collecting, incubating, and filtering multiple samples.
  87. Alfano Joseph C. ; Godfrey Martin R. ; Selvarajan Radhakrishnan ; Uhing Mary C., Monitoring boiler internal treatment with fluorescent-tagged polymers.
  88. Chandler Van S. ; Fulton R. Jerrold ; Chandler Mark B., Multiplexed analysis of clinical specimens apparatus and methods.
  89. Morris ; Jr. J. Glenn (Baltimore MD) Wright Anita (Baltimore MD), Nucleic acid probes specific for pathogenic strains of vibrio vulnificus and method employing the same.
  90. Hollis Mark A. (Concord MA) Ehrlich Daniel J. (Lexington MA) Murphy R. Allen (Boxboro MA) Kosicki Bernard B. (Acton MA) Rathman Dennis D. (Ashland MA) Chen Chang-Lee (Sudbury MA) Mathews Richard H. (, Optical and electrical methods and apparatus for molecule detection.
  91. Youvan Douglas C. ; Yang Mary M., Optical instrument having a variable optical filter.
  92. Wu, Jin; Ehmann, Ryan J.; Zhang, Lanhui; Ma, Lin; Lin, Liang-Bih; Levy, Daniel V., Photoconductors containing fluorinated components.
  93. Zlokarnik Gregor ; Negulescu Paul ; Knapp Tom ; Tsien Roger Y. ; Rink Tim, Photon reducing agents and compositions for fluorescence assays.
  94. Bisconte de Saint Julien Jean-Claude,FRX, Procedure for identifying the number of particles that are weakly luminescent.
  95. Bisconte Jean-Claude (Briis Sous Forges FRX), Process and apparatus for automatic analysis of elements in weak concentration on a support.
  96. Drocourt Jean-Louis (Yerres FRX) Desfetes Patrick (Saint Brice Sous Foret FRX) Sanghera Jaspal (Foxton GBX), Process for rapid and ultrasensitive detection and counting of microorganisms by fluorescence.
  97. Weaver James C. (Sudbury MA) Bliss Jonathan G. (Somerville MA) Williams Gregory B. (Tewksbury MA) Powell Kevin T. (Boston MA) Harrison Gail I. (Watertown MA), Process for rapidly enumerating viable entities.
  98. Straus, Don, Rapid and sensitive detection of cells and viruses.
  99. .O slashed.fjord Gro,NOX ; Skj.ang.nes Kari,NOX ; Aalen Nina,NOX ; Berg James D.,NOX, Rapid coliform detection system.
  100. Straus, Don, Rapid detection of replicating cells.
  101. Berg James D. (Aquateam ; Postboks 6593 ; Rodelokka 0501 Oslo 5 NOX), Rapid process for detection coliform bacteria.
  102. Bellus Peter A. (Eden Prairie MN) McKinney Terry L. (Severn MD), Real time spectroscopic imaging system and method.
  103. Piasio ; Roger N. ; Ryan ; James W. ; Woiszwillo ; James E., Reverse sandwich immunoassay.
  104. Roach, David J.; Loder, Jr., Robert T.; Armstrong, Thomas M.; Harris, Dennis W.; Jovanovich, Stevan B.; Johnston, Richard F., Robotic microchannel bioanalytical instrument.
  105. Modlin Douglas N., Sample holders with reference fiducials.
  106. Hunter ; William M., Separation of solid and liquid components of mixtures.
  107. Ju Jingyue, Sets of labeled energy transfer fluorescent primers and their use in multi component analysis.
  108. Pyle Barry H. ; McFeters Gordon A., Simple, rapid method for the detection, identification and enumeration of specific viable microorganisms.
  109. Bylina Edward J. ; Coleman William J. ; Dilworth Michael R. ; Silva Christopher M. ; Yang Mary M. ; Youvan Douglas C., Solid phase enzyme kinetics screening in microcolonies.
  110. Cerny Erich H., Solid phase transverse diffusion assay.
  111. Nelson Robert L. (Bloomington MN), Surface colony counting device and method of use.
  112. Dunlay, R. Terry; Taylor, D. Lansing; Gough, Albert H.; Giuliano, Kenneth A., System for cell-based screening.
  113. Wang Chia-Gee (Millwood NY), Tagged immunoassay.
  114. Charm Stanley E. ; Skiffington Richard ; Markovsky Robert J. ; Zomer Eliezer, Test device for detection of an analyte.
  115. Forrest Gordon C. (Ingatestone GB2), Test-tube assembly for immunoassays utilizing magnetically attractable particles.
  116. Bartelsman Bart W. (Canton MA) Fost Dennis L. (Ridgewood NJ), Transferring separated components in gel electrophoresis via nylon membrane.
  117. Kuster Martin (Eschenbach CHX) Forster Marco (Grueningen CHX), Transport system for fluid analysis instrument.
  118. Laurila Melvin J. ; Bachmann Claus C,DEX ; Klein Albert P.,DEX, X-ray fluorescence elemental analyzer.
  119. Pareigat Gerhardt H. (Hugo MN), Zoom lens having magnification factors in the range of 20X to 47X for micrographic applications.

이 특허를 인용한 특허 (10)

  1. Richards, William L.; Ashby, Austin; Ketterer, Matthew; Marshall, Kevin; Harrison, Josh; Mette, Matthew; Richards, Paul; Showalter, Wayne; Cote, Jasmin; Halbert, Phillip C.; Bourgeois, Solene; Metzger, Steven W.; Hance, Ken; Mensack, Meghan; Michel, Carlos; Allers, Elke; Gamage, Dulini; Prisbrey, Landon; Gusyatin, Oleg; Shamsheyeva, Alena; Turng, Ben; Ghusson, Andrew; Reinhardt, Kurt, Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing.
  2. Richards, William L.; Ashby, Austin; Ketterer, Matthew; Marshall, Kevin; Harrison, Josh; Mette, Matthew; Richards, Paul; Showalter, Wayne; Cote, Jasmin; Halbert, Phillip C.; Bourgeois, Solene; Metzger, Steven W.; Hance, Ken; Mensack, Meghan; Michel, Carlos; Allers, Elke; Gamage, Dulini; Prisbrey, Landon; Gusyatin, Oleg; Shamsheyeva, Alena; Turng, Ben; Ghusson, Andrew; Reinhardt, Kurt, Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing.
  3. Prisbrey, Landon; Blackmore, Elise; Hance, Kenneth R.; Metzger, Steven W.; Marshall, Kevin, Membrane-assisted purification.
  4. Abrams, Ezra; Gite, Sadanand; Shinefeld, Lisa; Straus, Don; Siek, Gordon; Yantz, Greg, Method for detecting analytes.
  5. Straus, Don, Rapid and sensitive detection of molecules.
  6. Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
  7. Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
  8. Shamsheyeva, Alena; Howson, David C.; Metzger, Steven W., Rapid determination of microbial growth and antimicrobial susceptibility.
  9. Metzger, Steven W.; Howson, David C.; Goldberg, David A.; Buttry, Daniel A., Rapid microbial detection and antimicrobial susceptibility testing.
  10. Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트