[특허]Method for improved fibrin sealing

Method for improved fibrin sealing 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61L-024/04 A61L-024/10 A61L-024/00 B65D-081/32
출원번호	US-0591265 (2015-01-07)
등록번호	US-9302026 (2016-04-05)
발명자 / 주소	Ilan, Erez Regev, Kfir Nur, Israel
출원인 / 주소	Omrix Biopharmaceuticals Ltd.
대리인 / 주소	Crichton, David R.
인용정보	피인용 횟수 : 0 인용 특허 : 21

초록

The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue.

대표청구항 ▼

1. A method for treating or preventing a defect in a moist tissue of a subject in need comprising the steps of: a) providing a component comprising solid fibrinogen, providing a component comprising a solid proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen; and providing a liquid fibrin sealant formulation;b) applying an effective amount of the solid components of a) onto at least a part of the moist tissue; andc) applying over at least a portion of the applied solid components an effective amount of the liquid fibrin sealant formulation of a). 2. The method according to claim 1, wherein the moist tissue is not enriched, has small amount, is deprived or lacks blood vessels and/or is an oozing or non-bleeding tissue. 3. The method according to claim 1, wherein the defect is a leak in the tissue. 4. The method according to claim 3, wherein the leaking substance is not enriched, has small amount, is deprived or lacks plasma or blood components. 5. The method according to claim 1, wherein the liquid fibrin sealant formulation is provided in solid form and reconstituted prior to its application. 6. The method according to claim 1, wherein the liquid fibrin sealant formulation is provided in frozen form and thawed prior to its application. 7. The method according to claim 1, wherein the solid component is provided in liquid form and dried prior to its application. 8. The method according to claim 1, wherein the solid component is provided in frozen form and dried prior to its application. 9. The method according to claim 1, wherein the solid components are applied simultaneously or one after the other. 10. The method according to claim 1, wherein the liquid components are applied simultaneously or one after the other. 11. The method according to claim 1, wherein the solid components of a) are provided in a blend. 12. The method according to claim 1, wherein the defect is a staple or a suture. 13. A kit comprising: (i) container(s) comprising solid components comprising (a)—fibrinogen component and (b)—a proteolytic enzyme component which is capable of forming fibrin when it reacts with fibrinogen, wherein the (a) and (b) components are in separate containers or in the same container as a blend; and (ii) at least two separated containers, the at least one separated container comprises a liquid, frozen or solid fibrinogen component, and the at least second separated container comprises a liquid, frozen or solid proteolytic enzyme component which is capable of forming fibrin when it reacts with fibrinogen, wherein when the at least two separated containers of (ii) comprise solid components, then the (a) and (b) components are in the same container as a blend. 14. The kit according to claim 13, wherein the proteolytic enzyme is thrombin. 15. The kit according to claim 13 for applying onto a wet surface. 16. The kit according to claim 13 for sealing leaks in tissues which are not enriched, have small amount, are deprived or lack blood vessels and/or tissues which are oozing or non-bleeding.

이 특허에 인용된 특허 (21)

Linder Albert (Leonberg-Hoefingen DEX) Kellner Andreas (Ulrichskirchen ATX) Habison Georg (Vienna ATX) Zuelow Guenther (Vienna ATX), Apparatus for applying a multiple-component tissue adhesive.
상세보기
Redl Heinz (Vienna ATX) Habison Georg (Vienna ATX), Apparatus for applying a tissue adhesive.
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Fukunaga Nobuto (Tamana JPX) Kawakami Katsumi (Kumamoto JPX) Uchida Takanori (Kumamoto JPX) Ishihara Yoshimitsu (Kikuchi-gun JPX), Applicator for applying a biocompatible adhesive.
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Capozzi Emil E. (Costa Mesa CA) Cooksten H. Stephen (Malibu CA), Biological syringe system.
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Dodge, Larry H., Dispenser for an adhesive tissue sealant having a flexible link.
상세보기
Stroetmann Michael (Mnster DEX), Enriched plasma derivative for advancement of wound closure and healing.
상세보기
Delmotte Yves,BEX ; Bilstad Arnold ; Amrani David ; Kennedy Mark ; DiOrio James, Fibrin delivery device and method for forming fibrin on a surface.
상세보기
Gordon Howard Epstein, Gas-driven spraying of mixed sealant agents.
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Seelich Thomas,ATX ; Turecek Peter,ATX, Hemostyptic and tissue adhesive.
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Petersen, Robert L.; Laird, James C.; Delcastillo, Jorge; Welter, Jacquelynn; Yardimci, Atif M., Method and apparatus for applying a medically useful multiple component material.
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Redl, Heinz, Method and device for mixing and applying components of differing viscosities.
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Tse Daphne C. ; Mankarious Samia S. ; Liu Shu Len ; Thomas William R. ; Alpern Melaine ; Enomoto Stanley T. ; Garanchon Cataline M., Method of preparing a topical fibrinogen complex.
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Kraus Michael (Frankfurt DEX) Mller Wolfgang (Oberursel DEX), Method of producing thrombin from factor II using calcium ions for the conversion on an anion exchanger.
상세보기
Sawyer Philip N. (Brooklyn NY) Sawyer Philip M. (Menlo Park CA) Reich Cary J. (Laguna Hills CA), Methods for sealing of staples and other fasteners in tissue.
상세보기
Drohan,William N.; MacPhee,Martin J.; Nunez,Hernan; Liau,Gene; Maciag,Thomas; Burgess,Wilson H., Methods for treating wound tissue and forming a supplemented fibrin matrix.
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Kablik,Joseph J.; Gentile,Andrew; Boccuti,A. David, Powder delivery device.
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Nur,Israel; Bar,Liliana; Azachi,Malkit, Removal of plasmin(ogen) from protein solutions.
상세보기
Zimmermann Josef (Sulzbach DEX), Spray head for the administration of a multi-component material by means of gas.
상세보기
Nur Israel,ILX ; Bar Lilliana,ILX ; Lieberman Oded,BEX, Stabilized mixture comprising fibrinogen.
상세보기
Seelich Thomas,ATX, Storage-stable fibrinogen preparations.
상세보기
Pines Eli (Watchung NJ) White William J. (Wayne PA), Therapeutic fibrinogen compositions.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Method for improved fibrin sealing 원문보기

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Method for improved fibrin sealing 원문보기

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