Cranial nerve stimulation to treat depression during sleep
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/00
A61N-001/36
A61B-005/0402
A61B-005/0476
A61B-005/0488
A61B-005/0496
A61B-005/11
A61B-005/00
A61N-001/05
출원번호
US-0262508
(2014-04-25)
등록번호
US-9302109
(2016-04-05)
발명자
/ 주소
Sabesan, Shivkumar
출원인 / 주소
CYBERONICS, INC.
대리인 / 주소
Foley & Lardner LLP
인용정보
피인용 횟수 :
1인용 특허 :
148
초록▼
A method includes determining sleep cycle information related to a sleep cycle of a patient based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the sleep cycle information. The method further includes applying a cranial nerve stimulation th
A method includes determining sleep cycle information related to a sleep cycle of a patient based on body parameter data. The method also includes adjusting a cranial nerve stimulation parameter based on the sleep cycle information. The method further includes applying a cranial nerve stimulation therapy to treat depression based on the adjusted cranial nerve stimulation parameter.
대표청구항▼
1. A method comprising: determining, at a computing device, sleep cycle information associated with a sleep cycle of a patient based on body parameter data;adjusting, at the computing device, a cranial nerve stimulation parameter based on the sleep cycle information, wherein the sleep cycle informat
1. A method comprising: determining, at a computing device, sleep cycle information associated with a sleep cycle of a patient based on body parameter data;adjusting, at the computing device, a cranial nerve stimulation parameter based on the sleep cycle information, wherein the sleep cycle information includes an amount of time the patient has spent in a particular sleep stage; andtreating depression in the patient by initiating application of a cranial nerve stimulation therapy to the patient based on the adjusted cranial nerve stimulation parameter. 2. The method of claim 1, wherein the body parameter data comprises at least one of electroencephalography (EEG) data, electrooculography (EOG) data, electromyography (EMG) data, electrocardiography (ECG) data, respiration data, or accelerometer data. 3. The method of claim 1, wherein the sleep cycle information further includes one of a sleep stage transition, an amount of time the patient has spent in one or more sleep stages during a particular sleep cycle, or an amount of time the patient has spent in the one or more sleep stages during a sleep period that includes multiple sleep cycles. 4. The method of claim 1, further comprising receiving the body parameter data from a sensor monitoring the patient. 5. The method of claim 1, further comprising: determining efficacy information of the cranial nerve stimulation therapy based on the sleep cycle information;determining a second adjusted cranial nerve stimulation parameter based on the efficacy information; andadjusting the cranial nerve stimulation therapy based on the second adjusted cranial nerve stimulation parameter. 6. The method of claim 5, further comprising: generating a report that includes the efficacy information, the second adjusted cranial nerve stimulation parameter, or a combination thereof; andcommunicating the report to at least one of the patient or a health care provider. 7. The method of claim 1, wherein the sleep cycle information further includes an amount of time the patient spent in a rapid eye movement (REM) stage sleep during a sleep period that includes one or more sleep cycles, and when the amount of time the patient has spent in the REM stage sleep is less than a threshold, the cranial nerve stimulation parameter is adjusted to apply the cranial nerve stimulation therapy to decrease brain synchrony. 8. The method of claim 1, wherein the cranial nerve stimulation therapy is applied to a vagus nerve, a trigeminal nerve, a hypoglossal nerve, a glossopharyngeal nerve, or a combination thereof, of the patient such that synchrony of a brain of the patient substantially conforms to a synchrony profile, and wherein the sleep cycle information further includes the particular sleep stage of the patient. 9. The method of claim 1, wherein the cranial nerve stimulation parameter includes at least one of a pulse width, an output current, a cranial nerve stimulation frequency, a cranial nerve stimulation duty cycle, a particular nerve or nerves stimulated, a cranial nerve stimulation frequency sweep, a cranial nerve stimulation on-time, or a cranial nerve stimulation off-time. 10. A device comprising: a processor configured to: determine sleep cycle information associated with a sleep cycle of a patient based on body parameter data; andadjust a cranial nerve stimulation parameter based on the sleep cycle information, wherein the sleep cycle information includes an amount of time the patient has spent in a particular sleep stage;a memory coupled to the processor; anda therapy delivery unit configured to apply a cranial nerve stimulation therapy to treat depression in the patient based on the adjusted cranial nerve stimulation parameter. 11. The device of claim 10, wherein the processor is further configured to: determine efficacy information of the cranial nerve stimulation therapy; andcommunicate the efficacy information of the cranial nerve stimulation therapy to a health care provider, the patient, or a combination thereof. 12. The device of claim 11, wherein the efficacy information of the cranial nerve stimulation therapy is determined based on a comparison of the sleep cycle information to second sleep cycle information of the patient prior to receiving the cranial nerve stimulation therapy. 13. The device of claim 11, wherein the efficacy information of the cranial nerve stimulation therapy is determined based on a comparison of an amount of time the patient has spent in rapid eye movement (REM) stage sleep to a threshold. 14. The device of claim 10, further comprising a transceiver coupled to the processor, the transceiver configured to communicate with a sensor data gathering unit to receive the body parameter data from a sensor that is attached to the patient. 15. The device of claim 11, wherein the processor is further configured to adjust the adjusted cranial nerve stimulation parameter based on the efficacy information. 16. A non-transitory computer-readable medium comprising instructions executable by a processor to: determine sleep cycle information associated with a sleep cycle of a patient based on body parameter data;adjust a cranial nerve stimulation parameter based on the sleep cycle information, wherein the sleep cycle information includes an amount of time the patient has spent in a particular sleep stage; andtreat depression in the patient by initiating application of a cranial nerve stimulation therapy to the patient based on the adjusted cranial nerve stimulation parameter. 17. The non-transitory computer-readable medium of claim 16, wherein the cranial nerve stimulation therapy comprises a microburst cranial nerve stimulation therapy. 18. The non-transitory computer-readable medium of claim 17, wherein the adjusted cranial nerve stimulation parameter includes at least one a cranial nerve stimulation frequency between 100 hertz (Hz) and 250 Hz, a pulse width between 250 microseconds and 500 microseconds, pulses per burst between 2 and 10, an interburst interval of 100 milliseconds to 1 second, or a burst duration of 100 milliseconds. 19. The method of claim 1, wherein the adjusted cranial nerve stimulation parameter includes a cranial nerve stimulation frequency less than 100 hertz (Hz) when transitioning the patient from stage 1 sleep into stage 2 sleep or from stage 2 sleep into stage 3 sleep. 20. The method of claim 1, wherein the adjusted cranial nerve stimulation parameter includes a cranial nerve stimulation frequency greater than or equal to 100 hertz (Hz) when transitioning the patient from stage 3 sleep into rapid eye movement (REM) stage sleep.
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