Apparatus and methods for delivering therapeutic agents
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-009/00
A61M-031/00
출원번호
US-0340095
(2008-12-19)
등록번호
US-9308124
(2016-04-12)
발명자
/ 주소
Humayun, Mark
Caffey, Sean
출원인 / 주소
University of Southern California
대리인 / 주소
Morgan, Lewis & Bockius LLP
인용정보
피인용 횟수 :
1인용 특허 :
155
초록
In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.
대표청구항▼
1. A method for treating an ophthalmic condition, comprising: implanting a drug-delivery device in a patient's eye, the device comprising (i) a refillable reservoir having a self-resealing upper layer that is pierceable by a needle for refilling and an opposed lower layer that is unpuncturable by th
1. A method for treating an ophthalmic condition, comprising: implanting a drug-delivery device in a patient's eye, the device comprising (i) a refillable reservoir having a self-resealing upper layer that is pierceable by a needle for refilling and an opposed lower layer that is unpuncturable by the needle so as to protect the eye from injury, (ii) a tapered cannula in fluid communication with the reservoir, and (iii) a valve disposed in the cannula, wherein the valve controls fluid delivery, maintains a constant flow rate independent of variations in pressure driving a fluid flow through the cannula, and prevents backflow; andfilling the reservoir with a liquid that comprises a therapeutic agent selected from the group consisting of acetazolamide, betaxolol, bevacizumab, bimatoprost, brimonidine, brinzolamide, carbidopa, carteolol, cidofovir, cyclosporine, dorzolamide, epinephrine, ketorolac tromethamine, ketotifen fumarate, latanoprost, levobetaxolol, levobunolol, levodopa, levofloxacin, loratadine, loteprednol etabonate, metipranolol, naphazoline, ofloxacin, pegaptanib, pemirolast, pheniramine maleate, pilocarpine, pseudoephedrine, ranibizumab, a steroid, timolol, travoprost, trifluridine, unoprostone isopropyl, valganciclovir, verteporfin, vitravene, a drug that prevents beta amyloid deposition in the retina, an anti-human complement activation blocker that blocks complement H activation in the eye, and siRNA molecules,wherein the device is implanted with the lower layer placed adjacent to the sclera of the eye and the cannula inserted into the eye through the sclera to facilitate delivery of drug from the reservoir into the eye. 2. The method of claim 1, further comprising directing the liquid to a target site via the cannula. 3. The method of claim 1, further comprising: (i) executing a stored drug-delivery regimen including a delivery pressure and a delivery flow rate of the liquid, (ii) receiving feedback from the patient, and (iii) modifying the stored drug-delivery regimen based on the feedback. 4. The method of claim 1, further comprising: (i) detecting the patient's position and activity;(ii) determining at least one of a frequency, time, or dosage of the liquid delivered to the patient based thereon; and(iii) responsively controlling delivery of the liquid. 5. The method of claim 4, wherein a dosage of the delivered liquid is controlled, at a constant flow rate, based on a duration that the liquid flows through the cannula.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (155)
Lattin Gary A. (Forest Lake MN) Padmanabhan Rama (Arden Hills MN) Grace Michael J. (Coon Rapids MN) Sorenson Paul D. (Blaine MN) Phipps Joseph B. (Plymouth MN) McNichols Larry A. (Coon Rapids MN), Activity controlled electrotransport drug delivery device.
Petit Michael G. (Santa Barbara CA), Apparatus for verifying the position of needle tip within the injection reservoir of an implantable medical device.
Langer Robert S. (Sommerville MA) Domb Abraham J. (Brookline MA) Laurencin Cato T. (Cambridge MA), Controlled drug delivery high molecular weight polyanhydrides.
Kam Robert J. (324 N. 19th St. San Jose CA 95112) Faste Rolf A. (90 Peter Coutts Circle Stanford CA 94305) Castro Anthony J. (2035 9th Ave. San Francisco CA 94116), Controlled release infusion device.
Howson David C. (Denver CO) Pauley J. Donald (Estes Park CO) Carroll Gary T. (Boulder CO), Device and method for precise subcutaneous placement of a medical instrument.
Tafani Jean-Pierre (Paris FRX) Valter Francis (Chatenay Malabry FRX) Zeghal Slim (Paris FRX) Alexandre Jean (Paris FRX), Device for delivering a pharmacologically active principle by electrolytic pumping.
Gross Joseph (Moshav Mazor ILX) Zucker Shlomo (Yavne ILX), Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate.
Beigler Myron A. (Los Altos Hills CA) Danby Hal C. (Palo Alto CA), Device for the intravenous or enteric infusion of liquids into the human body at a predetermined constant rate.
McKinnon ; Jr. Charles N. (7 Park Paseo Laguna Niguel CA 92677) Potter James T. (6795 SW. Larkspur Ct. Beaverton OR 97005) Mattocks Ken (538 Hartke Loop Oregon City OR 97045), Electrically powered jet injector.
Joshi,Ashok V.; Zecevic,Strahinja K.; Bhavaraju,Sai; Theeuwes,Felix; Wright,Jeremy Corwin, Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method.
Kuhl Dieter (Mohrendorf DEX) Luft Gunter (Lauf a.d. Pegnitz DEX) Mund Konrad (Erlangen DEX) Richter Gerhard (Erlangen DEX) Sturm Ferdinand V. (Erlangen DEX), Implantable dosing device.
Ashton Paul ; Patchell Roy A. ; Cooper Jon ; Young Byron A., Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body.
Gibson, Scott R.; Lord, Peter C.; Lorenzen, Eric M.; McConnell, Susan M.; Gray, John F.; Bosley, Robert W., Medical infusion device with a source of controlled compliance.
Jhuboo Nasser (St. Etienne de St. Geoirs FRX) Rondelet Jean-Claude (St. Etienne de Crossey FRX), Method and apparatus for determining pressure and detecting occlusions in a syringe pump.
Makower, Joshua; Lamson, Theodore C.; Flaherty, J. Christopher; Reggie, John A.; Chang, John Y.; Catanese, III, Joseph; Tholfsen, David R., Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites.
Unger, Marc A.; Chou, Hou-Pu; Thorsen, Todd A.; Scherer, Axel; Quake, Stephen R.; Enzelberger, Markus M.; Adams, Mark L.; Hansen, Carl L., Microfabricated elastomeric valve and pump systems.
Olsen, James M.; Lent, Mark S.; Skakoon, James G.; Stone, Richard T.; Mayor, Laetitia; Seeley, Dale F.; Hegland, Michael T., Miniature pump for drug delivery.
Darougar Sohrab,GBX ; Weiner Alan L. ; Bhatt Padmanabh Pravinchandra ; Raul Victor Albert ; Gantner David Clayton, Ocular insert with anchoring protrusions.
Robinson, Michael R.; Csaky, Karl G.; Yuan, Peng; Sung, Cynthia; Nussenblatt, Robert B.; Smith, Janine A., Ocular therapeutic agent delivery devices and methods for making and using such devices.
Chen Guohua ; Lautenbach Scott D. ; Dionne Keith E. ; Jordan Scott D. ; Berry Steve A. ; Rodenberger Craig I. ; Ayer Rupal, Osmotic delivery system, osmotic delivery system semimpermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems.
Larson ; Jr. Carl O. (Stonington CT) Smith James S. (Old Lyme CT) Chapman John H. (Groton CT) Slimon Scot A. (Mystic CT) John Trahan D. (No. Stonington CT) Brozek Robert J. (Bridgewater NJ) Franco Al, Surgically implantable pump arrangement and method for pumping body fluids.
Folkman Moses J. (18 Chathman Cir. Brookline MA 02146) Langer ; Jr. Robert S. (1200 Commonwealth ; Apt. 2 Allston MA 02134), Systems for the controlled release of macromolecules.
Price ; Jr. Francis W. (5511 Sunset La. Indianapolis IN 46208), Technique for fistulization of the eye and an eye filtration prosthesis useful therefor.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.