Low dose gamma sterilization of liquid adhesives
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-002/08
B65B-055/16
A61L-002/00
출원번호
US-0112483
(2011-05-20)
등록번호
US-9309019
(2016-04-12)
발명자
/ 주소
Zhang, Sheng
Ruiz, Sr., Rafael
출원인 / 주소
Adhezion Biomedical, LLC
대리인 / 주소
Stradley Ronon Stevens & Young, LLP
인용정보
피인용 횟수 :
0인용 특허 :
239
초록
Disclosed is a method for sterilizing adhesive 1.1-disubstituted alkylene monomer compositions, including alpha-cyanoacrylates, using low dose gamma irradiation.
대표청구항▼
1. A method for sterilizing a cyanoacrylate monomer adhesive composition, comprising adding a filtered cyanoacrylate monomer adhesive composition comprising monomeric 2-octyl cyanoacrylate, about 2 to about 50 ppm of sulfur dioxide, about 200 to about 15,000 ppm of butylated hydroxyl anisole and, op
1. A method for sterilizing a cyanoacrylate monomer adhesive composition, comprising adding a filtered cyanoacrylate monomer adhesive composition comprising monomeric 2-octyl cyanoacrylate, about 2 to about 50 ppm of sulfur dioxide, about 200 to about 15,000 ppm of butylated hydroxyl anisole and, optionally, 18-crown-6 crown ether to individual packaging elements, each individual packaging element comprising multiple layers, wherein the inner-most layer comprises a copolymer of acrylonitrile and methyl acrylate in a ratio of acrylonitrile to methyl acrylate of 75:25; packaging the individual packaging elements into a container, thereby forming a package; and irradiating the package with gamma radiation at a dose of from about 5 to about 10 k Gy, thereby sterilizing the package, wherein the-cyanoacrylate monomer adhesive contained within the container does not cure upon gamma irradiation and for at least two years of shelf storage thereafter. 2. The method of claim 1, wherein the cyanoacrylate monomer adhesive composition is filtered through a first filter having a pore size of from about 1 to about 200 μm. 3. The method of claim 1, wherein the density of the individual packaging elements and the container is from about 0.05 to about 0.5 gm/cm3. 4. The method of claim 3, wherein the density of the individual packaging elements and the container is from about 0.05 to about 0.40 gm/cm3. 5. The method of claim 1, wherein the dose of gamma radiation is about 5 k Gy. 6. The method of claim 1, wherein the cyanoacrylate monomer adhesive composition is filtered through a first filter and then through a second filter having a pore size of from about 0.01 to about 10 μm while under an inert and moisture-free atmosphere. 7. The method of claim 1, wherein the cyanoacrylate monomer adhesive composition comprises 18-crown-6 crown ether. 8. The method of claim 1, wherein the cyanoacrylate monomer adhesive composition comprises 5 to 45 ppm of sulfur dioxide and 2000 to 8000 ppm of butylated hydroxyl anisole. 9. A method for sterilizing a cyanoacrylate monomer composition, comprising adding a filtered cyanoacrylate monomer composition comprising monomeric n-butyl cyanoacrylate, monomeric 2-octyl cyanoacrylate, or a mixture of monomeric n-butyl cyanoacrylate and monomeric 2-octyl cyanoacrylate, from about 5 ppm to about 50 ppm of sulfur dioxide, from about 1000 to about 15,000 ppm of butylated hydroxyl anisole and, optionally, 18-crown-6 crown ether to a package comprising multiple layers, wherein the inner-most layer comprises a copolymer of acrylonitrile and methyl acrylate in a ratio of acrylonitrile to methyl acrylate of 75:25; and irradiating said package containing said cyanoacrylate monomer composition with gamma radiation at a dose of from about 5 to about 10 kGy, wherein the cyanoacrylate monomer adhesive contained within the package does not cure upon gamma irradiation and for at least two years of shelf storage thereafter. 10. The method of claim 9, wherein the cyanoacrylate monomer composition is filtered through a first filter having a pore size of from about 1 to about 200 μm. 11. The method of claim 9, wherein the density of the package is from about 0.05 to about 0.5 gm/cm3. 12. The method of claim 11, wherein the density of the package is from about 0.0.05 to about 0.40 gm/cm3. 13. The method of claim 9, wherein the dose of gamma radiation is about 5 k Gy. 14. The method of claim 9, wherein the cyanoacrylate monomer adhesive composition is filtered through a first filter and then through a second filter having a pore size of from about 0.01 to about 10 μm while under an inert and moisture-free atmosphere. 15. The method of claim 9, wherein the cyanoacrylate monomer composition comprises a crown ether. 16. The method of claim 9, wherein the cyanoacrylate monomer composition comprises 5 to 45 ppm of sulfur dioxide and 2000 to 8000 ppm of butylated hydroxyl anisole. 17. The method of claim 16, wherein the composition comprises monomeric n-butyl cyanoacrylate.
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