Method of using the detection of early increase in microvascular blood content to distinguish between adenomatous and hyperplastic polyps
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61B-005/0205
A61B-005/026
A61B-005/145
A61B-005/1455
A61B-005/1459
출원번호
US-0839234
(2013-03-15)
등록번호
US-9314164
(2016-04-19)
발명자
/ 주소
Backman, Vadim
Roy, Hemant
Kim, Young L.
Siegel, Michael
Turzhitsky, Vladimir
출원인 / 주소
NORTHWESTERN UNIVERSITY
대리인 / 주소
Oliff PLC
인용정보
피인용 횟수 :
0인용 특허 :
38
초록
The present invention, in one aspect, relates to a method for distinguishing between possible adenomatous and hyperplastic polyps using what is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue.
대표청구항▼
1. A method of providing an indication that a living polyp within a human body is either adenomatous or hyperplastic, comprising: inserting an illumination probe such that a light source within the illumination probe is disposed in a location that is at a surface of a colon and contains the polyp;il
1. A method of providing an indication that a living polyp within a human body is either adenomatous or hyperplastic, comprising: inserting an illumination probe such that a light source within the illumination probe is disposed in a location that is at a surface of a colon and contains the polyp;illuminating, at the location, tissue of the colon and microvasculature therein with light from the light source that is emitted from the probe around the polyp;detecting interacted light that results from the illuminating of the tissue as detected data, wherein the interacted light comprises light that has interacted with blood in the microvasculature that is within the tissue of the colon;estimating at least one of blood content and blood flow in the microvasculature using the detected data to obtain an estimation of the at least one of the blood content and the blood flow; andidentifying the polyp as being either adenomatous or hyperplastic based on the estimation of the at least one of the blood content and the blood flow, the identifying of the polyp as being either adenomatous or hyperplastic comprising determining whether there is an increase in the estimation of the at least one of the blood content and the blood flow in the microvasculature. 2. The method according to claim 1, further comprising removing the polyp if the polyp is identified as being adenomatous, while not removing the polyp if the polyp is identified as being hyperplastic. 3. The method according to claim 1, further comprising: visually examining the polyp with light if the polyp is indicated as being adenomatous; andremoving the polyp if the poly is indicated as being adenomatous. 4. The method according to claim 1, wherein the interacted light comprises light that is scattered by the blood in the microvasculature. 5. The method according to claim 1, wherein the interacted light comprises light that is scattered and absorbed by the blood in the microvasculature. 6. The method according to claim 1, wherein the interacted light comprises light that is absorbed by the blood in the microvasculature. 7. The method according to claim 1, wherein the illumination probe is inserted into an inner surface of the colon. 8. The method according to claim 1, wherein the detecting of the interacted light comprises detecting at least one component of the interacted light selected from the group consisting of co-polarized, cross-polarized, and unpolarized interacted light. 9. The method according to claim 8, wherein the blood content is estimated. 10. The method according to claim 9, wherein the blood content is estimated by estimating a concentration of red blood cells. 11. The method according to claim 9, wherein the blood content is estimated by estimating a concentration of hemoglobin. 12. The method according to claim 9, wherein the blood content is estimated by estimating a concentration of de-oxygenated hemoglobin. 13. The method according to claim 9, wherein the blood content is estimated by estimating a concentration of oxygenated hemoglobin. 14. The method according to claim 8, wherein the blood flow is estimated by estimating a rate of blood flow. 15. The method according to claim 9, wherein the blood content is estimated by estimating oxygen saturation in the blood. 16. The method according to claim 8, wherein the at least one of the blood content and the blood flow is estimated by estimating a statistic of the at least one of the blood content and the blood flow within an area of the tissue. 17. The method according to claim 16, wherein the statistic is selected from the group consisting of mean, average, median, standard deviation, maximal value, and minimal value. 18. The method according to claim 8, wherein the interacted light is detected from the surface of the colon to a submucosal layer. 19. The method according to claim 8, wherein the interacted light is detected from the surface of the colon to a mucosal layer. 20. The method according to claim 1, further comprising performing a screening colonoscopy during a same period of time as the inserting of the illumination probe, the illuminating of the tissue of the colon and the microvasculature therein, and the detecting of the interacted light. 21. The method according to claim 1, further comprising performing a sigmoidoscopy during a same period of time as the inserting of the illumination probe, the illuminating of the tissue of the colon and the microvasculature therein, and the detecting of the interacted light. 22. The method according to claim 1, wherein the inserting of the illumination probe, the illuminating of the tissue of the colon and the microvasculature therein, and the detecting of the interacted light are performed using a stand-alone probe. 23. The method according to claim 1, wherein the inserting of the illumination probe, the illuminating of the tissue of the colon and the microvasculature therein, and the detecting of the interacted light are performed using a probe disposed at least partially within an endoscopic device. 24. The method according to claim 1, wherein the identifying of the polyp as being either adenomatous or hyperplastic comprises comparing the estimation of the blood content with a baseline blood content. 25. The method according to claim 24, further comprising establishing the baseline blood content. 26. The method according to claim 25, further comprising establishing the baseline blood content based upon measurements of blood content of a region surrounding the colon. 27. The method according to claim 25, further comprising establishing the baseline blood content based upon measurements of blood content of a plurality of bodies other than the body. 28. The method according to claim 25, further comprising establishing the baseline blood content based upon measurements of blood content of the body. 29. The method according to claim 1, wherein the blood content is estimated. 30. The method according to claim 29, wherein the blood content is estimated by estimating a concentration of red blood cells. 31. The method according to claim 29, wherein the blood content is estimated by estimating a concentration of hemoglobin. 32. The method according to claim 29, wherein the blood content is estimated by estimating a concentration of de-oxygenated hemoglobin. 33. The method according to claim 29, wherein the blood content is estimated by estimating a concentration of oxygenated hemoglobin. 34. The method according to claim 1, wherein the blood flow is estimated by estimating a rate of blood flow. 35. The method according to claim 29, wherein the blood content is estimated by estimating oxygen saturation in the blood. 36. The method according to claim 1, wherein the at least one of the blood content and the blood flow is estimated by estimating a statistic of the at least one of the blood content and the blood flow within an area of the tissue. 37. The method according to claim 36, wherein the statistic is selected from the group consisting of mean, average, median, standard deviation, maximal value, and minimal value.
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