Methods and compositions for promoting wound healing
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/198
A61K-031/133
A61K-033/38
A61K-045/06
A61L-026/00
A61L-015/44
A61L-015/20
A61L-015/18
출원번호
US-0873545
(2015-10-02)
등록번호
US-9314482
(2016-04-19)
발명자
/ 주소
Wooley, Richard E.
Ritchie, Branson W.
Kemp, Douglas T.
Capomacchia, Anthony C.
Burnley, Victoria V.
출원인 / 주소
Wooley, Richard E.
대리인 / 주소
Smith Tempel Blaha LLC
인용정보
피인용 횟수 :
0인용 특허 :
55
초록▼
The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amoun
The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.
대표청구항▼
1. A composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water, saline, physiological saline, an ointment, a cream, an oil-water emulsion, and a gel, wherein the Tris, EDTA, and dissolved silver are in amounts suff
1. A composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water, saline, physiological saline, an ointment, a cream, an oil-water emulsion, and a gel, wherein the Tris, EDTA, and dissolved silver are in amounts sufficient to promote healing of a burn on a mammalian, bird, or reptile body, the composition consisting of a pH of from 6.0 to 9.0, and optionally, a detergent, a vitamin, an anti-inflammatory agent, lecithin, glycerin, methyl paraben, aloe vera, polypropylene glycol ethoxylate, and/or poloxamer 407. 2. The composition according to claim 1 wherein the detergent is from 1% to 30% of the composition by volume/volume. 3. The composition according to claim 1 wherein the silver is at a concentration of from 1 ppm to 300 ppm. 4. The composition according to claim 3 wherein the silver is at a concentration of from 1 ppm to 50 ppm. 5. The composition according to claim 1 wherein the EDTA is at a concentration of from 1 mM to 250 mM. 6. The composition according to claim 1 wherein the Tris is at a concentration of from 10 mM to 250 mM. 7. A composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water, saline, physiological saline, an ointment, a cream, an oil-water emulsion, and a gel, wherein the Tris, EDTA, and dissolved silver are in amounts sufficient to promote healing of a wound on a mammalian, bird, or reptile body, the composition consisting of a pH of from 6.0 to 9.0, and optionally, a detergent, a vitamin, an anti-inflammatory agent, lecithin, glycerin, methyl paraben, aloe vera, polypropylene glycol ethoxylate, and/or poloxamer 407. 8. The composition according to claim 7 wherein the detergent is from 1% to 30% of the composition by volume/volume. 9. The composition according to claim 7 wherein the silver is at a concentration of from 1 ppm to 300 ppm. 10. The composition according to claim 9 wherein the silver is at a concentration of from 1 ppm to 50 ppm. 11. The composition according to claim 7 wherein the EDTA is at a concentration of from 1 mM to 250 mM. 12. The composition according to claim 11 wherein the Tris is at a concentration in the formulation of from 10 mM to 250 mM. 13. A burn dressing consisting of a bondage or a gauze and the composition according to claim 1. 14. A wound dressing consisting of a bandage or a gauze and the composition according to claim 7. 15. The wound dressing according to claim 14 wherein the wound dressing is a wound dressing for an ulcer. 16. The composition according to claim 1 wherein the mammalian body is a human body. 17. The composition according to claim 7 wherein the mammalian body is a human body.
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