Highly reliable ingestible event markers and methods for using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61B-005/07
A61B-005/145
H01M-002/02
H01M-002/14
H01M-002/00
A61K-009/00
출원번호
US-0756280
(2013-01-31)
등록번호
US-9320455
(2016-04-26)
발명자
/ 주소
Hafezi, Hooman
Au-Yeung, Kityee
Duck, Robert
Holen, Maria Casillas
Robertson, Timothy
Costello, Benedict James
출원인 / 주소
Proteus Digital Health, Inc.
대리인 / 주소
K&L Gates LLP
인용정보
피인용 횟수 :
5인용 특허 :
338
초록▼
Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more component
Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.
대표청구항▼
1. An ingestible event marker comprising: a support;a control circuit physically associated with the support to control the event marker;a first electrochemical material physically associated with the support and electrically coupled to the control circuit;a second electrochemical material electrica
1. An ingestible event marker comprising: a support;a control circuit physically associated with the support to control the event marker;a first electrochemical material physically associated with the support and electrically coupled to the control circuit;a second electrochemical material electrically coupled to the control circuit and physically associated with the support at a location different from the location of the first material such that the first and second electrochemical materials are electrically isolated from each other, wherein the first electrochemical material is dissimilar from the second electrochemical material, and wherein the first and second electrochemical materials are configured to produce an actual dipole having a predefined dipole length, wherein the actual dipole length is a distance between the first electrochemical material and the second electrochemical material; anda membrane physically associated with the support and positioned between the first electrochemical material and the second electrochemical material to produce a virtual dipole having a length defined by a distance across the membrane, wherein the virtual dipole length is larger than the actual dipole length; andwherein the first and the second electrochemical materials are configured to generate a voltage potential to power the control circuit when the first and the second electrochemical materials come into contact with an electrically conductive liquid at a target physiological site. 2. The ingestible event marker of claim 1, wherein upon application of the voltage potential to the control circuit, the control circuit is configured to generate a conductive signal to transmit information. 3. The ingestible event marker of claim 1, wherein the membrane defines at least one opposing curved edge. 4. The ingestible event marker of claim 1, wherein the membrane comprises at least one projection. 5. The ingestible event marker of claim 1, wherein the membrane defines a concave shape configuration. 6. The ingestible event marker of claim 1 wherein the membrane comprises at least one depolyable elements. 7. The ingestible event marker of claim 6, wherein the at least one depolyable element comprises a plurality of arms, and wherein each of the plurality of arms defines a first configuration and a second configuration. 8. The ingestible event marker of claim 1, wherein the membrane defines a planar structure defining an outer edge that extends beyond an edge defined by the first electrochemical material and an edge defined by the second electrochemical material. 9. The ingestible event marker of claim 1, wherein the membrane comprises at least one of multiple coatings and multiple layers. 10. The ingestible event marker of claim 1, wherein the membrane is a composite structure made of at least two materials. 11. The ingestible event marker of claim 10, wherein the membrane comprises an insulative material coupled to a metallic layer. 12. The ingestible event marker of claim 1, wherein the membrane comprises an electrically insulative material configured to dissolve in a predetermined amount of time when in contact with a physiological fluid. 13. The ingestible event marker of claim 1, further comprising a weight non-centrically associated with the membrane. 14. The ingestible event marker of claim 1, further comprising a water-swellable component non-centrically associated with the membrane. 15. The ingestible event marker of claim 1, further comprising an active agent. 16. The ingestible event marker of claim 15, wherein the active agent is physically associated with the membrane and the membrane is configured to release the active agent in a phased manner. 17. The ingestible event marker of claim 15, wherein the active agent comprises at least one fluid passageway. 18. A system comprising: an active agent; andan ingestible event marker comprising: a support;a control circuit physically associated with the support to control the event marker;a first electrochemical material physically associated with the support and electrically coupled to the control circuit;a second electrochemical material electrically coupled to the control circuit and physically associated with the support at a location different from the location of the first material such that the first and second electrochemical materials are electrically isolated from each other, wherein the first electrochemical material is dissimilar from the second electrochemical material, and wherein the first and second electrochemical materials are configured to produce an actual dipole having a predefined dipole length, wherein the actual dipole length is a distance between the first electrochemical material and the second electrochemical material; anda membrane physically associated with the support and positioned between the first electrochemical material and the second electrochemical material to produce a virtual dipole having a length defined by the membrane, wherein the virtual dipole length is larger than the actual dipole length; andwherein the first and the second electrochemical materials are configured to generate a voltage potential to power the control circuit when the first and the second electrochemical materials come into contact with an electrically conductive liquid at a target physiological site. 19. The system of claim 18, wherein the event marker further comprising at least one of a non-active agent salt, an anti-foaming agent, a micro-environment modification agent, or a soluble component having a weight equal or greater to 90% of the overall weight of the ingestible event marker. 20. The system of claim 18, wherein the membrane defines a planar structure defining an outer edge that extends beyond an edge defined by the first and second electrochemical materials and wherein the membrane comprises at least one of an opposing curved edge, a projection, or a deployable element. 21. The ingestible event marker of claim 1, wherein the membrane is dimensioned to increase a length of a current path through a conducting liquid in a body between the first and second electrochemical materials. 22. The system of claim 18, wherein the membrane is dimensioned to increase a length of a current path through a conducting liquid in a body between the first and second electrochemical materials.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (338)
Neil Brian K. (Issaquah WA), Abrasive skin electrode.
Kolter, Karl; Schonherr, Michael; Ascherl, Hermann, Active ingredient-containing floating forms comprising polyvinyl acetate and polyvinylpyrrolidone, their use and production.
Goscha,Donald L.; Haeder,Lisa D.; Kadhiresan,Veerichetty A.; Johnson,David C.; Srivathsa,Muralidharan; Brockway,Marina, Ambulatory repeater for use in automated patient care and method thereof.
Hayward, Roger; Fuller, Richard; Glissman, John; Marshall, Noel, Antenna design utilizing a cavity architecture for global positioning system (GPS) applications.
Cosentino, Louis C.; Duea, Michael John; Duea, Duane Robert; Dorfe, Steven George; Nubson, Richard C.; Cosentino, Judith A., Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients.
Cosentino, Daniel L.; Cosentino, Louis C.; Dorfe, Steven George; Duea, Duane Robert, Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients.
Bealka, David Joseph; Vaillancourt, Christien Matthew; Kimock, Fred Michael; Gill, Emma Claire, Co-fired metal and ceramic composite feedthrough assemblies for use at least in implantable medical devices and methods for making the same.
Hafezi, Hooman; O'Reilly, David; Johnson, Patricia; Hatamkhany, Zahedeh; Robertson, Timothy, Communication system incorporated in an ingestible product.
Hafezi, Hooman; O'Reilly, David; Johnson, Patricia; Hatamkhany, Zahedeh; Robertson, Timothy, Communication system incorporated in an ingestible product.
Sadri, Ali S.; Maltsev, Alexander; Maslennikov, Roman; Khoryaev, Alexey; Sergeyev, Vadim, Communication within a wireless network using multiple frequency bands.
Markki,Outi; Ekberg,Jan Erik; Kokkinenh,Heikki; Kuoppala,Mika, Content distribution & communication system for enhancing service distribution in short range radio environment.
Del Castillo Leonardo ; Danieli Damon Vincent ; Randell Scott ; Ranta Craig S. ; Singh Harjit, Controller and associated mechanical characters operable for continuously performing received control data while engaging in bidirectional communications over a single communications channel.
Doi, Kenji; Hashimoto, Masaru; Koyama, Masaki; Suzuki, Yoshiko; Nishimura, Tokuhisa, Data transmission system using a human body as a signal transmission path.
Lewkowicz,Shlomo; Gat,Daniel; Kraizer,Yehudit; Gilad,Zvika; Leuw,David; Meron,Gavriel; Glukhovsky,Arkady, Device and method for examining a body lumen.
Zacouto Fred (16 rue de la Convention 75 015 Paris FRX), Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemo.
Hugemann Berhhard (Frankfurt am Main DEX) Schuster Otto (Bad Soden DEX), Device for the release of substances at defined locations in the alimentary tract.
Andersson Jan A. R. (S. Sandby SEX) Nilsson Nils G. (Lund SEX) Fagerstrm Per-Olof S. (Bjrred SEX) Wendel Thomas M. (Genarp SEX), Device in connection with an inhaler.
Caldwell Larry J. (Lawrence KS) Gardner Colin R. (Lawrence KS) Cargill Robyn C. (Lawrence KS), Drug delivery device which can be retained in the stomach for a controlled period of time.
Muehlsteff,Jens; Reiter,Harald; Montvay,Andras; Lauter,Josef; Such,Olaf; Schmidt,Ralf; Perkuhn,Michael; Kohler,Fabian, Electrode assembly and a system with impedance control.
Malick,Crista; Qi,Xie; Parikh,Mitesh; Franke,Steve; Jones,Douglas L.; Larsen,Jeffery B.; Schmitz,Christopher D.; Callias,Francois, Electrode placement for wireless intrabody communication between components of a hearing system.
Savage, George; Hafezi, Hooman; Colliou, Olivier; Zdeblick, Mark; Strand, Angela, Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same.
Christophersom, Mark A.; Donders, Adrianus P.; Miesel, Keith A.; Twetan, Len D., Externally worn transceiver for use with an implantable medical device.
Omidian, Hossein; Qiu, Yong; Yang, Shicheng; Kim, Dukjoon; Park, Haesun; Park, Kinam, Hydrogels having enhanced elasticity and mechanical strength properties.
Thompson, David L.; Greeninger, Daniel R.; Goedeke, Steven D., Implantable medical device controlled by a non-invasive physiological data measurement device.
Vock Josef (Spanga SEX) Ljungstroem Jan (Solna SEX) Ekwall Christer (Spanga SEX), Implantable medical device with means for telemetric transmission of data.
Casper Robert A. (Raleigh NC) McCartney Michael L. (Durham NC) Jochem Warren J. (Cary NC) Parr Alan F. (Cary NC), Medical capsule device actuated by radio-frequency (RF) signal.
David L. Thompson ; Steven D. Goedeke, Medical management system integrated programming apparatus for communication with an implantable medical device.
Hannam Clifford (Pulborough GB2) Harwood Gerald A. (Thetford GB2), Metal detecting apparatus and apparatus including guide housing for guiding a metal test piece, for testing metal detect.
Mazar,Scott T.; Manicka,Yatheendhar D., Method and apparatus for enabling data communication between an implantable medical device and a patient management system.
Lu, Kan; Jiang, Chongjun; Chen, Michael; Xu, Bin; Tang, Yiyan; Hong, Huiyong; Wu, Shuangli; Wu, Feng, Method and device for providing multiple communication protocols with a single transceiver.
King, Dennis; Astley, Ken; Tarassenko, Lionel; Anuzis, Paul; Hayton, Paul; King, Stephen, Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components.
Serpa,Mark; Alhemsi,Hani; Ratajski,Greg; Ashlock,Bob, Method and system for peer-to-peer wireless communication over unlicensed communication spectrum.
Faraji, Boozarjomehr; Ha, Kevin Jun; Talbot, Neil Hamilton; Little, James Singleton; Greenberg, Robert J., Method of inspection of materials for defects.
Lloyd Lindsay B. (West Jordan UT) Beck Jon E. (Salt Lake City UT) Petelenz Tomasz J. (Salt Lake City UT) Jacobsen Stephen C. (Salt Lake City UT), Method of making a hydratable bioelectrode.
Cofino Thomas Anthony ; Friedman Daniel Joseph ; Goldman Kenneth Alan ; Heinrich Harley Kent, Method of using write--ok flag for radio frequency (RF) transponders (RF Tags).
Haller,Amit; Fornell,Peter; Itzchak,Avraham; Haparnas,Ziv, Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network.
Haller, Amit; Haparnas, Ziv, Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network.
Heller,Adam; Mano,Nicholas; Kim,Hyug Han; Zhang,Yongchao; Mao,Fei; Chen,Ting; Barton,Scott Calabrese, Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods.
Francis A. Spelman ; Page Read ; N. Mani Prakash ; James A. Nelson ; Charles E. Pope ; Margaret Heitkemper ; James D. Rothermel, Non-invasive gut motility monitor.
Greenberg, Robert J; Ok, Jerry; Neysmith, Jordan Matthew; Wilkin, Kevin; Talbot, Neil Hamilton; Chang, Da-Yu, Package for an implantable neural stimulation device.
Ok, Jerry; Greenberg, Robert J.; Talbot, Neil Hamilton; Little, James Singleton; Dai, Rongqing; Neysmith, Jordan Matthew; McClure, Kelly H., Package for an implantable neural stimulation device.
Welch, James P.; Baker, Steven D.; Guilak, Farzin G.; Sampath, Anand; Williams, Daniel L., Personal status physiologic monitor system and architecture and related monitoring methods.
Nikfar Faranak (Bridgewater NJ) Serajuddin Abu T. M. (Flushing NY) Jerzewski Robert L. (Belle Mead NJ) Jain Nemichand B. (Cranbury NJ), Pharmaceutical compositions having good dissolution properties.
Ryu,Chang Yong; Kim,Seung Hwan; Kim,Youn Tae, Physiological signal detection module, multi-channel connector module and physiological signal detection apparatus using the same.
Ricks Robert D. (Newark CA) Bornn Robert (San Francisco CA) Hurt David B. (Mountain View CA), Portable, multi-channel, physiological data monitoring system.
Harrison, Christopher; Mullins, Oliver C.; Vancauwenberghe, Olivier; Donzier, Eric P.; Chikenji, Akihito; Goodwin, Anthony Robert Holmes; Pop, Julian J., Protective barriers for small devices.
Greenberg, Robert J.; Ok, Jerry; Neysmith, Jordan; Wilkins, Kevin; Talbot, Neil Hamilton; Chang, Da-Yu, Retinal prosthesis and method of manufacturing a retinal prosthesis.
Mastrocola Angelo R. (West Lawn PA) Sonntag Jeffrey L. (Rockland Township ; Berks County PA), Ring oscillator using even numbers of differential stages with current mirrors.
Atkinson Linda E. (Portola Valley CA) Dunn John T. (Palo Alto CA) Gale Robert M. (Los Altos CA) Rivera David L. (San Jose CA), Segmented device for simultaneous delivery of multiple beneficial agents.
Bashaw John D. (Palo Alto CA) Zaffaroni Alejandro (Atherton CA) Michaels Alan S. (Atherton CA), Self-monitored device for releasing agent at functional rate.
Yasuda,Mitsuyoshi; Itoh,Katsutoshi; Natori,Makoto; Yokoshi,Minoru; Yoshimura,Osamu; Itagaki,Takeshi, Short range wireless communication system, portable terminal apparatus, and wireless communication apparatus.
Teller, Eric; Stivoric, John M.; Kasabach, Christopher D.; Pacione, Christopher D.; Moss, John L.; Liden, Craig B.; McCormack, Margaret A., System for monitoring health, wellness and fitness.
Stivoric, John M.; Moss, John L.; Kasabach, Christopher D.; Boehmke, Scott K.; Zaremsky, Mark; Sica, Vanessa, System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow.
Nolan Michael P. (Elk Grove IL), System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages usin.
Flax Stephen W. (Wauwatosa WI) Bahr Dennis E. (Middleton WI), System for the compacting and logical linking of data blocks in files to optimize available physical storage.
Salazar Joe Andrew ; Molero-Castro Luis,ESX, Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.