초록 ▼

Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an

Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can be connected to the source of bodily fluid via a connector that is configured to maintain uniform velocity across the connector and reduce the dead space volume.

대표청구항 ▼

1. An accommodating medical connector configured to reduce leaks and improve fluid flow between a medical device and a source of body fluid, the accommodating connector comprising: an outer housing having an elongate housing axis, a first side configured to accept standard medical tubing comprising

1. An accommodating medical connector configured to reduce leaks and improve fluid flow between a medical device and a source of body fluid, the accommodating connector comprising: an outer housing having an elongate housing axis, a first side configured to accept standard medical tubing comprising an incoming fluid line, and a connecting side having an outer connecting structure configured to securely but removably interlock with an outer portion of a standard medical connector to form an interior volume;an elongate cylindrical tube having a stiffness greater than the standard medical tubing and having an elongate tube axis, the elongate cylindrical tube positioned so its elongate tube axis is generally aligned with and concentric to the elongate housing axis of the outer housing, an interior of the elongate cylindrical tube forming a fluid path and terminating at a port, the elongate cylindrical tube configured to extend from the accommodating connector through the outer connecting structure at the connecting side and protrude into the interior volume in a direction aligned with the elongate axis and fluid path such that the elongate cylindrical tube carries fluid through the interior volume and allows the fluid to flow out of the port and into a lumen of the standard medical connector, the interior of the elongate cylindrical tube aligned with the lumen and having a diameter that corresponds to a diameter of the lumen to improve fluid flow;a hub within the outer housing, the hub having a longitudinal hub being axially aligned with both the incoming fluid line and the elongate tube axis and positioned between them to form a secure connection such that any movement of the elongate cylindrical tube in a direction of the elongate tube axis and the elongate housing axis causes corresponding movement of the incoming fluid line, the fluid path passing through the hub; anda spring configured to exert force on the elongate cylindrical tube or hub in a direction aligned with the fluid path such that the elongate cylindrical tube protrudes into the interior volume and resiliently abuts the lumen of the standard medical connector such that when fluid passes through the interior volume and out of the port, it continues directly into the aligned lumen of the standard medical connector, minimizing leakage. 2. The accommodating connector of claim 1, wherein the standard medical connector comprises a standard Luer connector, and wherein the accommodating connector is configured to connect with a fluid line attached to a patient. 3. The accommodating connector of claim 2, wherein the fluid line comprises a central venous catheter. 4. The accommodating connector of claim 2, wherein the fluid line comprises a peripheral venous catheter. 5. The accommodating connector of claim 2, wherein the fluid line has a diameter of up to 16 gauge. 6. The accommodating connector of claim 1, wherein the standard medical connector is selected from a group consisting of connectors with standard Luer threading and having a linear depth between an entrance to the standard medical connector and the inner lumen in the range of approximately 6.9 mm to approximately 19.8 mm, and wherein the spring is configured to cause the elongate cylindrical tube to resiliently protrude through a similar range such that the accommodating medical connector can accommodate standard medical connectors having depths in the range of approximately 6.9 mm to approximately 19.8 mm while protruding fully into the interior volume of each and resiliently abutting the lumen of each such standard medical connector. 7. The accommodating connector of claim 1, wherein the accommodating connector can withstand a pressure of up to approximately 100 psi. 8. The accommodating connector of claim 1, configured to maintain uniform velocity of the bodily fluid across the accommodating connector. 9. The accommodating connector of claim 1, wherein an inner diameter of the elongate cylindrical tube of the accommodating connector is approximately the same as an inner diameter of the lumen of the standard connector and as a diameter of an internal lumen of the incoming fluid line. 10. The accommodating connector of claim 1, wherein the accommodating connector is configured to reduce dead volume by allowing fluid to bypass the interior volume and avoid flowing into the interior volume. 11. The accommodating connector of claim 1, wherein the elongate cylindrical tube comprises polyimide. 12. The accommodating connector of claim 2, wherein the tube has a tip at one end which is configured to connect with the fluid line in the patient. 13. The accommodating connector of claim 12, wherein the tip of the tube has a square cross-sectional shape. 14. The accommodating connector of claim 12, wherein the tip of the tube has a conical cross-sectional shape. 15. The accommodating connector of claim 12, wherein the tip of the elongate cylindrical tube is tapered. 16. The accommodating connector of claim 12, wherein the tip of the elongate cylindrical tube is beveled. 17. The accommodating connector of claim 12, wherein the tip of the elongate cylindrical tube comprises a stiff material compared to the lumen of the standard medical connector. 18. The accommodating connector of claim 17, wherein the tip of the elongate cylindrical tube comprises polyimide. 19. A medical connector comprising: an outer housing having an elongate housing axis, a first side configured to accept standard medical tubing comprising an incoming fluid line, and a connecting side having an outer connecting structure configured to securely but removably interlock with an outer portion of a standard medical connector having standard luer threading;an elongate tube having a stiffness greater than the standard medical tubing and having an elongate tube axis, the elongate tube positioned so its elongate tube axis is generally aligned with and concentric to the elongate housing axis of the outer housing, the elongate tube configured to extend from the connector through the outer connecting structure at the connecting side and protrude in a direction aligned with the elongate tube axis and with a fluid path such that the elongate tube allows a fluid to flow into a lumen of the standard medical connector, an interior of the elongate tube aligned with the lumen;a secure connection between the incoming fluid line and the elongate tube such that any movement of the elongate tube in a direction aligned with the elongate tube axis causes corresponding movement of the incoming fluid line; anda resilient structure configured to exert force directly or indirectly on the elongate tube in a direction aligned with the fluid path such that the elongate tube resiliently abuts the standard medical connector at an opening to an inner lumen of the standard medical connector, allowing the fluid to flow directly between the elongate tube and the inner lumen of the standard medical connector, minimizing leakage. 20. The medical connector of claim 19, wherein the resilient structure is configured to allow the elongate tube to resiliently protrude to a range of lengths sufficient to mate with and abut the standard medical connector at an opening to the inner lumen of the standard medical connector, the standard medical connector having a depth ranging from at least approximately 6.9 mm to approximately 19.8 mm. 21. The medical connector of claim 19, wherein the incoming fluid line comprises a central venous catheter. 22. The medical connector of claim 19, wherein the incoming fluid line comprises a peripheral venous catheter. 23. The medical connector of claim 19, wherein the incoming fluid line has a diameter of up to 16 gauge. 24. The medical connector of claim 19, wherein the medical connector is configured to reduce dead volume by allowing fluid to bypass an interior volume of the outer housing and avoid flowing into the interior volume. 25. The medical connector of claim 19, wherein the elongate tube comprises polyimide. 26. The medical connector of claim 19, wherein the elongate tube has a tip at one end which is configured to connect with a fluid line in a patient. 27. The medical connector of claim 26, wherein the tip of the elongate tube has a square cross-sectional shape. 28. The medical connector of claim 26, wherein the tip of the elongate tube has a conical cross-sectional shape. 29. The medical connector of claim 26, wherein the tip of the elongate tube is tapered. 30. The medical connector of claim 26, wherein the tip of the elongate tube is beveled. 31. The medical connector of claim 26, wherein the tip of the elongate tube comprises a stiff material compared to the inner lumen of the standard medical connector. 32. The medical connector of claim 26, wherein the tip of the elongate tube comprises polyimide.