Antimicrobial silver hydrogel composition for the treatment of burns and wounds
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-033/38
A61P-017/02
A61P-031/10
A61P-031/12
A61K-036/886
A61P-031/04
A61K-047/10
A61K-009/00
A61K-047/26
A61K-047/32
A61K-047/38
출원번호
US-0101724
(2011-05-05)
등록번호
US-9327029
(2016-05-03)
발명자
/ 주소
Yates, Kenneth M.
Proctor, Celia A
Atchley, Dan H
출원인 / 주소
CelaCare Technologies, LLC
대리인 / 주소
Jackson Walker L.L.P.
인용정보
피인용 횟수 :
0인용 특허 :
4
초록▼
An antimicrobial therapeutic hydrogel composition comprises a pharmaceutical and/or medical grade silver salt, and an Aloe vera gel or extract. The composition could also include stabilizing agents, a non-ionic surfactant, polyol, and hydrophilic hygroscopic polymers. The resulting product has poten
An antimicrobial therapeutic hydrogel composition comprises a pharmaceutical and/or medical grade silver salt, and an Aloe vera gel or extract. The composition could also include stabilizing agents, a non-ionic surfactant, polyol, and hydrophilic hygroscopic polymers. The resulting product has potent antimicrobial activity against bacteria, protozoa, fungi and viruses. The antimicrobial therapeutic composition can serve as a treatment for burns and as a wound/lesion dressing that either donates or receives moisture to provide a physiologic environment for accelerated wound healing and the relief of pain.
대표청구항▼
1. An antimicrobial hydrogel comprising: (a) a soluble silver salt;(b) acemannan; and(c) ethylenediaminetetraacetic acid (EDTA) in a concentration of 0.01-5 w/w %;wherein the soluble silver salt is anhydrous or hydrous stabilized having a concentration of ionic silver in the range of 0.01-100 ppm; a
1. An antimicrobial hydrogel comprising: (a) a soluble silver salt;(b) acemannan; and(c) ethylenediaminetetraacetic acid (EDTA) in a concentration of 0.01-5 w/w %;wherein the soluble silver salt is anhydrous or hydrous stabilized having a concentration of ionic silver in the range of 0.01-100 ppm; and wherein the acemannan has a concentration of 0.01 to 1.0 w/w %. 2. The composition of claim 1, wherein the silver salt is selected from the group consisting of silver citrate, silver dihydrogen citrate, silver chloride, silver acetate, silver nitrate, silver fusidate, silver benzoate, silver gluconate, and silver galacturonate. 3. The composition of claim 1, wherein the acemannan is in an anhydrous form, and wherein the acemannan was separated using an alcohol precipitation method, a column purification method or an ultrafiltration method in an aqueous vehicle. 4. The composition of claim 1, further comprising polyvinylpyrrolidone. 5. The composition of claim 4, wherein the polyvinylpyrrolidone is in the concentration of 0.1 to 5.0 w/w %. 6. The composition of claim 1, further comprising a sorbitan ester. 7. The composition of claim 6, further comprising the sorbitan ester, polysorbate. 8. The composition of claim 7, wherein the concentration of polysorbate is 0.01-0.2 w/w %. 9. The composition of claim 1, further comprising allantoin. 10. The composition of claim 9, wherein the concentration of allantoin is 0.0001-2.0 w/w %. 11. The composition of claim 1, further comprising the humectant, panthenol. 12. The composition of claim 11, wherein panthenol is in the concentration of 0.1-3.0 w/w %. 13. The composition of claim 1, further comprising the humectant, propylene glycol. 14. The composition of claim 13, wherein propylene glycol is in the concentration of 0.01-1.0 w/w %. 15. The composition of claim 1, further comprising a humectant. 16. The composition of claim 1, further comprising a non-ionic water soluble polymer. 17. The composition of claim 16, wherein the non-ionic water soluble polymer is hydroxyethylcellulose. 18. The composition of claim 16, wherein the non-ionic water soluble polymer is carboxymethylcellulose. 19. The composition of claim 16, wherein the non-ionic water soluble polymer is hydroxypropylcellulose. 20. The composition of claim 16, wherein the concentration of non-ionic water soluble polymer is 0.01-5.0 w/w %. 21. The composition of claim 1, wherein the composition is buffered to a pH 4-7.4. 22. A method of treating bacteria, fungi, protozoa and/or virus infected wounds/lesions or burns in a subject, comprising topically administering to the subject an effective amount of the composition of claim 1. 23. A method of treating bacteria, fungi, protozoa and/or virus infected wounds/lesions or burns in a subject, comprising topically administering to the subject an effective amount of the composition of claim 16. 24. A method of treating bacteria, fungi, protozoa and/or virus infected wounds/lesions or burns in a subject, comprising topically administering to the subject an effective amount of the therapeutic composition of claim 16, wherein the therapeutic composition has more potent broad-spectrum antimicrobial activity than its corresponding aqueous silver salt alone. 25. A method of treating a wound/lesion or burn in a subject, comprising topically administering to the subject an effective amount of the therapeutic composition of claim 16, wherein the therapeutic composition will create a physiologic environment for optimal and/or accelerated wound healing. 26. A method of treating a wound/lesion or burn in a subject, comprising topically administering to the subject an effective amount of the composition of claim 16 that relieves pain. 27. A method of treating a wound/lesion or burn in a subject, comprising topically administering to the subject an effective amount of the composition of claim 16 that will absorb or donate moisture for optimal physiologic healing of the wound/lesion or burn.
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이 특허에 인용된 특허 (4)
Beerse Peter William ; Biedermann Kimberly Ann ; Page Steven Hardy ; Mobley Michael Joseph ; Morgan Jeffrey Michael, Antimicrobial compositions comprising a benzoic acid analog and a metal salt.
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