Implantable electroacupuncture device and method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/00
A61N-001/375
A61N-001/36
A61N-001/372
A61N-001/378
출원번호
US-0796314
(2013-03-12)
등록번호
US-9327134
(2016-05-03)
발명자
/ 주소
Greiner, Jeffrey H.
Peterson, David K. L.
Thenuwara, Chuladatta
Greiner, Stacy O.
출원인 / 주소
Valencia Technologies Corporation
대리인 / 주소
Gold, Bryant R.
인용정보
피인용 횟수 :
2인용 특허 :
43
초록▼
An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupunctu
An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
대표청구항▼
1. An Implantable ElectroAcupuncture Device (IEAD) for treating a specified medical condition of a patient through application of electroacupuncture (EA) stimulation pulses adapted to be applied substantially at or near a specified target tissue location, comprising: a small IEAD housing having an e
1. An Implantable ElectroAcupuncture Device (IEAD) for treating a specified medical condition of a patient through application of electroacupuncture (EA) stimulation pulses adapted to be applied substantially at or near a specified target tissue location, comprising: a small IEAD housing having an electrode configuration thereon that includes at least two electrodes/arrays, the longest linear dimension of the small IEAD housing being no greater than about 25 mm, and the shortest linear dimension, measured orthogonal to the longest linear dimension, is no greater than about 2.5 mm, wherein at least one of said at least two electrodes/arrays comprises a central electrode/array located substantially in the center of a first surface of the IEAD housing, and wherein at least another of said at least two electrodes/arrays comprises a circumferential electrode/array located substantially around and at least 5 mm distant from the center of the central electrode/array, wherein the first surface (106) of the IEAD housing when implanted is adapted to face inwardly into the patient's tissue at or near the specified target tissue location;pulse generation circuitry located within the IEAD housing and electrically coupled to the at least two electrodes/arrays, wherein said pulse generation circuitry is adapted to deliver stimulation pulses to the patient's body tissue at or near the target tissue location in accordance with a specified stimulation regimen, said stimulation regimen defining the duration (T3) and rate (1/T4) at which a stimulation session is applied to the patient, said stimulation regimen requiring that the stimulation session have a duration of T3 minutes and a rate of occurrence of once every T4 minutes, wherein the ratio of T3/T4 is no greater than 0.05, and wherein during each stimulation session EA stimulation pulses having one or more specified widths (T1) and amplitudes (A1) are generated at one or more specified rates (1/T2);a primary battery contained within the IEAD housing and electrically coupled to the pulse generation circuitry that provides operating power for the pulse generation circuitry, said primary battery having a nominal output voltage of 3 volts, and an internal impedance greater than 5 ohms; anda sensor contained within the IEAD housing responsive to operating commands wirelessly communicated to the IEAD from a non-implanted location, said operating commands allowing limited external control of the IEAD. 2. The IEAD of claim 1 wherein the circumferential electrode/array comprises an anode electrode/array and the central electrode/array comprises a cathode electrode/array. 3. The IEAD of claim 1 wherein the small IEAD housing is coin-shaped having a diameter no greater than about 25 mm and a thickness of no greater than about 2.5 mm. 4. The IEAD of claim 3 wherein the specified medical condition comprises at least one of (1) hypertension, (2) cardiovascular disease, (3) depression, (4) bipolar disorder, (5) Anxiety, (6) obesity, (7) dyslipidemia, (8) Parkinson's disease, (9) Essential tremor, or (10) erectile dysfunction. 5. The IEAD of claim 4 wherein the specified target tissue location comprises at least one acupoint selected from the group of acupoints comprising: BL14, BL23, BL52, EXHN1, EXHN3, GB34, GV4, GV20, HT5, HT7, KI6, L14, LI11, LR3, LR8, LU2, LU7, PC5, PC6, PC7, SP4, SP6, SP9, ST36, ST37, and ST40. 6. The IEAD of claim 1 wherein the pulse generation circuitry includes: a boost converter circuit that boosts the nominal voltage of the primary battery to an output voltage VOUT that is at least three times the nominal battery voltage;means for selectively turning the boost converter circuit OFF and ON to limit the amount of current that may be drawn from the primary battery; andan output circuit powered by VOUT that generates the stimulation pulses as defined by the specified stimulation regimen. 7. The IEAD of claim 6 wherein the stimulation pulses generated by the pulse generation circuit and delivered through the at least two electrodes/arrays into a load at the target tissue location comprise current pulses having a current amplitude of no less than about 1 milliampere (mA) and no greater than about 25 mA. 8. The IEAD of claim 7 wherein the primary battery has sufficient capacity to power the pulse generation circuitry in accordance with the specified stimulation regimen for a minimum of 2 years. 9. The IEAD of claim 6 wherein the means for selectively turning the boost converter circuit OFF and ON comprises a control circuit configured to generate a digital signal that modulates the boost converter circuit between an OFF state and an ON state, with the ON state comprising no more than about 2% of the time that the IEAD is operating. 10. The IEAD of claim 6 wherein the means for selectively turning the boost converter circuit OFF and ON comprises a boost converter circuit having a shut down feature which automatically places the boost converter circuit in an OFF state whenever the battery voltage falls below a set minimum value, wherein the set minimum value of the battery below which the boost converter is placed in an OFF state comprises a voltage that is sufficiently high to continue to power other digital processing circuits within the pulse generation circuitry even when the boost converter is turned OFF. 11. The IEAD of claim 10 wherein the pulse generation circuitry further includes circuitry configured to create a reverse trapezoidal stimulation pulse waveshape for the stimulation pulses. 12. The IEAD of claim 11 wherein the pulse generation circuitry further includes means for reducing leading edge transient signals that may be present in the stimulation pulses generated by the pulse generation circuitry. 13. The IEAD of claim 12 wherein the output circuit of the pulse generation circuitry includes a programmable current source, and wherein the means for reducing leading edge transient signals comprises connecting a cascode circuit at the input of the programmable current source. 14. The IEAD of claim 13 wherein the pulse generation circuitry further includes means for kick starting the programmable current source when low amplitude stimulation pulses are generated, wherein such kick starting eliminates or reduces undesired delays in the leading edge of the stimulation pulses generated by the pulse generation circuitry. 15. The IEAD of claim 11 wherein the specified medical condition comprises hypertension and wherein the specified target tissue location comprises at least one of the acupoints PC5, PC6, ST36 or ST37. 16. The IEAD of claim 11 wherein the specified medical condition comprises at least one of depression, bipolar disorder and Anxiety, and wherein the specified target tissue location comprises at least one of the acupoints GV20 or EXHN3. 17. The IEAD of claim 11 wherein the specified medical condition comprises cardiovascular disease and wherein the specified target tissue location comprises at least one of the acupoints: BL14, EXHN1, HT5, HT7, LI11, LU2, LU7, PC6, or ST36. 18. The IEAD of claim 11 wherein the specified medical condition comprises dyslipidemia or obesity and wherein the specified target tissue location comprises at least one of the acupoints: KI6, LR8, SP4, SP6, SP9, ST36, ST37 or ST40. 19. The IEAD of claim 11 wherein the specified medical condition comprises Parkinson's disease or Essential tremor and wherein the specified target tissue location comprises at least one of the acupoints GB34 or GV20. 20. The IEAD of claim 11 wherein the specified medical condition comprises erectile dysfunction and wherein the specified target tissue location comprises at least one of the acupoints GV4, BL23 or BL52.
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