최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0433175 (2012-03-28) |
등록번호 | US-9332974 (2016-05-10) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 213 인용 특허 : 2265 |
A tissue thickness compensator may generally comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a third layer comprising a third medicament. The tissue thickness compensator may comprise a first layer comprising a first medicament, a second layer
A tissue thickness compensator may generally comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a third layer comprising a third medicament. The tissue thickness compensator may comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a reservoir comprising a third medicament disposed within the reservoir. The medicaments may be independently selected from a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a pharmaceutically active agent, a matrix metalloproteinase inhibitor, and combinations thereof. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
1. A tissue thickness compensator, comprising: a first layer comprising a first medicament;a second layer comprising a second medicament, wherein the second medicament is different than the first medicament; anda third layer comprising a third medicament disposed between the first layer and the seco
1. A tissue thickness compensator, comprising: a first layer comprising a first medicament;a second layer comprising a second medicament, wherein the second medicament is different than the first medicament; anda third layer comprising a third medicament disposed between the first layer and the second layer, wherein the third medicament is different than the second medicament and the first medicament, and wherein at least one of the first layer, the second layer, and the third layer comprises an adaptive thickness for compensating for variations in tissue thickness. 2. The tissue thickness compensator of claim 1, wherein the first medicament, second medicament, and third medicament are independently selected from a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a pharmaceutically active agent, a matrix metalloproteinase inhibitor, and combinations thereof. 3. The tissue thickness compensator of claim 1, wherein the first medicament comprises a haemostatic agent, the second medicament comprises an anti-adhesion agent, and the third medicament comprises a matrix metalloproteinase inhibitor. 4. The tissue thickness compensator of claim 1, wherein the first layer comprises a first film comprising a haemostatic agent, the second layer comprises a second film comprising an anti-adhesion agent, and the third layer comprises a biocompatible foam having a matrix metalloproteinase inhibitor homogeneously distributed therein. 5. The tissue thickness compensator of claim 4, wherein the first film is mechanically bonded to the biocompatible foam. 6. The tissue thickness compensator of claim 1, wherein the first layer, second layer, and third layer are independently selected from polylactides, poly(lactic acid), polyglycolides, poly(glycolic acid), poly(trimethylene carbonate), poly(dioxanone), poly(hydroxybutyric acid), poly(hydroxyvaleric acid), poly(lactide-co-(ε-caprolactone)), poly(glycolide-co-(ε-caprolactone)), poly(lactic-co-glycolic acid), polycarbonates, poly(pseudo amino acids), poly(amino acids), poly(hydroxyalkanoate)s, polyalkylene oxalates, polyoxaesters, polyanhydrides, polyortho esters, and copolymers, block copolymers, homopolymers, blends, and combinations thereof. 7. The tissue thickness compensator of claim 1, wherein the first layer comprises a biodegradable polymer, and the third medicament elutes from the third layer when the first layer degrades. 8. The tissue thickness compensator of claim 1, wherein the first layer comprises at least one of the second medicament and third medicament. 9. The tissue thickness compensator of claim 1, wherein the first layer comprises collagen, gelatin, thrombin, fibrin, fibrinogen, fibronectin, elastin, albumin, hemoglobin, ovalbumin, polysaccharides, hyaluronic acid, chondroitin sulfate, hydroxyethyl starch, hydroxyethyl cellulose, cellulose, oxidized cellulose, hydroxypropyl cellulose, carboxyethyl cellulose, carboxymethyl cellulose, chitan, chitosan, agarose, maltose, maltodextrin, alginate, clotting factors, methacrylate, polyurethanes, cyanoacrylates, platelet agonists, vasoconstrictors, alum, calcium, RGD peptides, proteins, protamine sulfate,ε-amino caproic acid, ferric sulfate, ferric subsulfates, ferric chloride, zinc, zinc chloride, aluminum chloride, aluminum sulfates, aluminum acetates, permanganates, tannins, bone wax, polyethylene glycols, fucans and combinations thereof. 10. The tissue thickness compensator of claim 1, wherein the second layer comprises poly(vinyl pyrrolidone), carboxymethyl cellulose, hyaluronic acid, polyethylene oxide, poly vinyl alcohols, doxycycline, diclofenac, aspirin, naproxen, sulindac, hydrocortisone, and combinations thereof. 11. The tissue thickness compensator of claim 1, wherein the second layer comprises one of a powder, a gel, and a fluid. 12. A tissue thickness compensator, comprising: a plurality of layers, wherein the plurality of layers comprises: a first layer;a second layer; anda third layer disposed between the first layer and the second layer;wherein at least one of the layers comprises a film layer, wherein at least one of the layers comprises a fibrous layer, and wherein at least one of the layers comprises a medicament, and wherein at least one of the first layer, the second layer, and the third layer comprises an adaptive thickness for compensating for variations in tissue thickness. 13. The tissue thickness compensator of claim 12, wherein the medicament is selected from a group consisting of a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a pharmaceutically active agent, a matrix metalloproteinase inhibitor, and combinations thereof. 14. The tissue thickness compensator of claim 12, wherein at least two of the layers comprise a porous layer. 15. The tissue thickness compensator of claim 14, wherein the first layer comprises a first porous layer, wherein the second layer comprises a second porous layer, and wherein the third layer comprises the film layer. 16. The tissue thickness compensator of claim 15, wherein the first porous layer comprises a first density, wherein the second porous layer comprises a second density, and wherein the second density is different than the first density. 17. The tissue thickness compensator of claim 15, wherein the first porous layer comprises a woven material. 18. The tissue thickness compensator of claim 15, wherein the plurality of layers are bonded together. 19. The tissue thickness compensator of claim 15, wherein the plurality of layers are welded together. 20. A tissue thickness compensator, comprising: a first compressible layer;a second compressible layer, wherein the first compressible layer and the second compressible layer comprise an adaptive thickness for compensating for variations in tissue thickness; anda film layer disposed between the first compressible layer and the second compressible layer. 21. The tissue thickness compensator of claim 20, further comprising a medicament. 22. The tissue thickness compensator of claim 21, wherein the medicament is selected from a group consisting of a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a pharmaceutically active agent, a matrix metalloproteinase inhibitor, and combinations thereof. 23. The tissue thickness compensator of claim 20, wherein the film layer is bonded to the first compressible layer and the second compressible layer. 24. The tissue thickness compensator of claim 20, wherein the first compressible layer comprises a first density, wherein the second compressible layer comprises a second density, and wherein the second density is different than the first density. 25. The tissue thickness compensator of claim 24, wherein the first compressible layer is comprised of a first porous, fibrous material, and wherein the second compressible layer is comprised of a second porous, fibrous material.
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