Method of making a medical textile from polyhydroxyalkanoate fibers
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
D01D-005/08
D01D-005/092
D01D-005/12
D02J-001/22
A61F-002/00
A61L-027/18
A61L-031/06
D01F-006/62
D01F-006/84
D01D-005/088
D01D-005/16
D02G-003/02
A61L-027/48
D01D-005/098
출원번호
US-0276708
(2014-05-13)
등록번호
US-9333066
(2016-05-10)
발명자
/ 주소
Martin, David P.
Rizk, Said
Ahuja, Ajay
Williams, Simon F.
출원인 / 주소
Tepha, Inc.
대리인 / 주소
Pabst Patent Group LLP
인용정보
피인용 횟수 :
0인용 특허 :
130
초록▼
Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than a
Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
대표청구항▼
1. A method of making a medical textile from a fiber comprising poly-4-hydroxybutyrate polymer (P4HB), wherein the fiber has a tensile strength greater than 126 MPa, comprising melt extruding the P4HB polymer, allowing the extruded fiber time to crystallize and cool at or to a temperature that is gr
1. A method of making a medical textile from a fiber comprising poly-4-hydroxybutyrate polymer (P4HB), wherein the fiber has a tensile strength greater than 126 MPa, comprising melt extruding the P4HB polymer, allowing the extruded fiber time to crystallize and cool at or to a temperature that is greater than the glass transition temperature of the polymer, and stretching the fiber at a temperature above the polymer's glass transition temperature. 2. The method of claim 1 wherein the fiber has been heat set. 3. The method of claim 1 wherein the medical textile is a mesh or braid. 4. The method of claim 3 wherein the mesh is knitted, woven or braided. 5. The method of claim 4 wherein the mesh is a monofilament mesh. 6. The method of claim 5 wherein the mesh is a warp knit. 7. The method of claim 6 wherein the fiber has an elongation to break of over 20%. 8. The method of claim 3 wherein the braid is formed from a multifilament yarn of poly-4-hydroxybutyrate polymer. 9. The method of claim 8 wherein the braid comprises multifilament yarn and monofilament of poly-4-hydroxybutyrate polymer. 10. The method of claim 1 wherein the medical textile has a breaking strength of at least 10 psi. 11. The method of claim 1 wherein the diameter of the fiber is between 82 μm and 217 μm. 12. The method of claim 1 wherein the medical textile is selected from the group consisting of a tube, general surgical mesh, suture, hernia mesh, pericardial patch, anti-adhesion patch, cardiovascular patch, guided tissue regeneration patch, sling, braid, ligament and tendon repair device, meniscus repair device, cartilage repair device, nerve guide, stent, vascular graft, dural patch, organ salvage device, intracardiac defect closure device, mastopexy/breast reconstruction device, tracheal reconstruction device and bladder repair device. 13. The method of claim 1 wherein the polymer is a copolymer of 4-hydroxybutyrate and one or more co-monomers. 14. The method of claim 13 wherein the co-monomer is glycolate or 3-hydroxybutyrate. 15. The method of claim 1 wherein the medical textile is combined with harvested autologous, allogeneic and/or xenogeneic tissue. 16. The method of claim 1 wherein the medical textile is used for hernia repair, mastopexy/breast reconstruction, rotator cuff repair, suturing, wound healing, vascular grafting/fistulae, tissue flaps, pericardial patching in intracardiac repair, tissue heart valve implants, bowel interposition, and dura patching.
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