Engineered polypeptide agents for targeted broad spectrum influenza neutralization
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07K-014/00
G01N-033/569
C07K-014/005
A61K-038/00
출원번호
US-0163882
(2014-01-24)
등록번호
US-9334309
(2016-05-10)
발명자
/ 주소
Sasisekharan, Ram
Viswanathan, Karthik
Soundararajan, Venkataramanan
Raguram, S.
Sasisekharan, Viswanathan
Subramanian, Vidya
출원인 / 주소
Massachusetts Institute of Technology
대리인 / 주소
Choate, Hall & Stewart LLP
인용정보
피인용 횟수 :
1인용 특허 :
30
초록▼
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The
The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.
대표청구항▼
1. A method comprising steps of: providing a sample from a patient suspected of suffering from an influenza infection;contacting the sample with an infold agent that binds a hemagglutinin (HA) polypeptide, wherein the infold agent comprises an infold selected from the group consisting of Infold-1, I
1. A method comprising steps of: providing a sample from a patient suspected of suffering from an influenza infection;contacting the sample with an infold agent that binds a hemagglutinin (HA) polypeptide, wherein the infold agent comprises an infold selected from the group consisting of Infold-1, Infold-2, Infold-3, Infold-4, Infold-5, Infold-6, Infold-7, Infold-8, Infold-9, Infold-10, Infold-11, Infold-12, Infold-13, Infold-14, Infold-15, Infold-16, Infold-17, Infold-18, Infold-19, Infold-20, Infold-21, Infold-22, Infold-23, Infold-24, Infold-25, Infold-26, Infold-27, Infold-28, Infold-29, Infold-30, Infold-31, Infold-32, Infold-33, Infold-34, Infold-35, Infold-36, Infold-37, Infold-38, Infold-39, and Infold-40; anddetecting binding of the infold agent to components in the sample; andbased on the detected binding, diagnosing the patient as suffering from an influenza infection. 2. The method of claim 1, wherein prior to the step of contacting, the sample is processed by subjecting it to one or more purification steps. 3. The method of claim 1, wherein the infold agent is labeled with a detectable moiety. 4. The method of claim 3, wherein the detectable moiety is a fluorescent moiety. 5. The method of claim 3, wherein the detectable moiety is a radioactive moiety. 6. The method of claim 3, wherein the detectable moiety is a chemoluminescent moiety. 7. The method of claim 1, wherein the infold agent is detected by an immunological method. 8. The method of claim 7, wherein the immunological method is Western blotting. 9. The method of claim 7, wherein the immunological method is ELISA. 10. The method of claim 7, wherein the immunological method is immunofluorescence. 11. The method of claim 1, wherein the infold agent is immobilized. 12. The method of claim 11, wherein the infold agent is immobilized to a bead. 13. The method of claim 11, wherein the infold agent is immobilized to a microtiter dish. 14. The method of claim 11, wherein the infold agent is immobilized to an array. 15. The method of claim 14, wherein the array is a glycan array.
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