Estrogenic extracts of Asparagus conchinchinensis (Lour.) Merr of the Liliaceae family and uses thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-036/00
A61K-036/70
출원번호
US-0205661
(2008-09-05)
등록번호
US-9339523
(2016-05-17)
발명자
/ 주소
Cohen, Isaac
출원인 / 주소
BIONOVO, INC.
대리인 / 주소
Volpe and Koenig, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
11
초록▼
Estrogenic extracts of Asparagus conchinchinensis (Lour.) Merr of the Liliaceae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptom
Estrogenic extracts of Asparagus conchinchinensis (Lour.) Merr of the Liliaceae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.
대표청구항▼
1. A composition that modulates the expression of a gene under control of an estrogen response element, wherein the composition consists of: (a) at least one member of the group consisting of pharmaceutically acceptable solvents, diluents, flavorings, and sweeteners; (b) an extract obtained from a p
1. A composition that modulates the expression of a gene under control of an estrogen response element, wherein the composition consists of: (a) at least one member of the group consisting of pharmaceutically acceptable solvents, diluents, flavorings, and sweeteners; (b) an extract obtained from a plant or a part thereof, wherein the plant is a member of the taxonomic species Asparagus cochinchinensis (Lour.) Merr of the Liliaceae family, the extract includes one or more compounds dissolved in a solvent selected from the group consisting of: ethyl acetate, acetonitrile, hexanes, alcohol, methanol, ethanol, i-propanol, n-propanol, n-butanol, t-butanol, s-butanol, i-butanol, chloroform, acetone, cyclohexane, cycloheptane, and petroleum ether, wherein the one or more compounds are capable of binding at least one of estrogen receptors ERα and ERβ in cells growing in vitro or in vivo; and (c) and at least one active pharmaceutical ingredient that exhibits synergistic activity in combination with the extract and selectively modulates estrogen receptors, the at least one active pharmaceutical ingredient comprising raloxifene or tamoxifen. 2. The composition of claim 1, wherein modulation of the expression of a gene under control of an estrogen response element treats or prevents a climacteric symptom; treats or prevents osteoporosis; treats or prevents a neoplasia; treats or prevents cardiovascular disease; or a combination thereof. 3. The composition of claim 2, wherein modulation of the expression of a gene under control of an estrogen response element treats a climacteric symptom. 4. The composition of claim 2, wherein the climacteric symptom is hot flashes, vaginal dryness, decreased libido or urinary incontinence. 5. The composition of claim 4, wherein the climacteric symptom is hot flashes. 6. The composition of claim 1 further comprising an amount of the extract that is sufficient to provide a patient relief from one or more climacteric symptoms, osteoporosis, or a combination thereof. 7. The composition of claim 6, wherein the amount of the extract included in the composition is in a range from 1 mg to 10,000 mg. 8. A composition comprising at least two separate units, wherein a first unit comprises an extract obtained from a plant or a part thereof, wherein the plant is a member of the taxonomic species Asparagus cochinchinensis (Lour.) Merr of the Liliaceae family, the extract includes one or more compounds dissolved in a solvent selected from the group consisting of: ethyl acetate, acetonitrile, hexanes, alcohol, methanol, ethanol, i-propanol, n-propanol, n-butanol, t-butanol, s-butanol, i-butanol, chloroform, acetone, cyclohexane, cycloheptane, and petroleum ether, wherein the one or more compounds are capable of binding at least one of estrogen receptors ERα and ERβ in cells growing in vitro or in vivo; and a second unit comprises raloxifene or tamoxifen.
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