Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/34
A61N-001/04
A61N-002/02
A61N-001/36
A61N-001/378
A61N-002/00
A61N-001/05
A61B-005/00
출원번호
US-0840936
(2013-03-15)
등록번호
US-9339641
(2016-05-17)
발명자
/ 주소
Rajguru, Amit
Burnett, Daniel R.
출원인 / 주소
EMKinetics, Inc.
대리인 / 주소
Levine Bagade Han LLP
인용정보
피인용 횟수 :
4인용 특허 :
176
초록▼
Various methods and devices for providing transdermal electrical stimulation therapy to a patient are provided. In certain variations, a method may include positioning a stimulator electrode over a glabrous skin surface overlying a target nerve of a subject. Electrical stimulation may be delivered t
Various methods and devices for providing transdermal electrical stimulation therapy to a patient are provided. In certain variations, a method may include positioning a stimulator electrode over a glabrous skin surface overlying a target nerve of a subject. Electrical stimulation may be delivered through or across the glabrous skin surface to the target nerve to stimulate the target nerve, while remaining safe and tolerable to the patient. Electrical stimulation may be delivered at frequencies that may be painful or intolerable when applied over non-glabrous surfaces of the body. Various applicators or devices for providing transdermal electrical stimulation therapy are also provided.
대표청구항▼
1. A method for providing transdermal electrical stimulation therapy to a subject comprising: positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject;delivering, via a pulse generator, electrical stimulation transdermally through the glabrous skin surface and
1. A method for providing transdermal electrical stimulation therapy to a subject comprising: positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject;delivering, via a pulse generator, electrical stimulation transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand until pain felt by the subject is mitigated;providing feedback signals based on F-wave detection, andadjusting or optimizing the electrical stimulation delivered through the glabrous skin surface and to the target nerve or tissue within the hand based on the F-wave detection. 2. The method of claim 1, wherein the electrical stimulation is delivered at a frequency of about 5 Hz to about 60 Hz, while remaining safe and tolerable to the subject. 3. The method of claim 1, wherein the stimulator electrode is a surface electrode. 4. The method of claim 1. wherein the electrical stimulation is delivered intermittently or on a chronic basis. 5. The method of claim 1. further comprising: detecting nerve stimulation via at least one sensor positioned on the subject:receiving a signal from the sensor indicative of the detected electrical stimulation thereby providing a feedback about the efficacy of the applied electrical stimulation therapy such that the therapy is adjusted or optimized. 6. The method of claim 5, wherein the feedback is queried such that the electrical stimulation therapy is adjusted to ensure that a minimum amount of energy is being applied to stimulate the target nerve within the hand while reducing the risk of burns or intolerance. 7. The method of claim 5, wherein the feedback is queried such that the positioning of the stimulator electrode is adjusted to optimize the electrical stimulation therapy. 8. The method of claim 5, wherein the sensor is selected from the group consisting of a surface electrode, microneedle electrode, or motion sensor. 9. The method of claim 5, wherein afferent nerve stimulation is detected. 10. The method of claim 1, further comprising positioning a ground electrode on the subject to facilitate penetration of an electrical current through the glabrous surface to stimulate the target nerve within the hand. 11. The method of claim 1, wherein the stimulator electrode is attached to the glabrous skin surface with an adhesive. 12. The method of claim 1, wherein the stimulator electrode is positioned over the glabrous skin surface with an ergonomic applicator. 13. The method of claim 12, wherein the applicator is a glove or brace configured to he positioned against the palmar surface of a hand such that the electrode delivers electrical stimulation to a target nerve within the hand. 14. The method of claim 12, wherein the applicator and/or one or more electrodes are coated with a pain relief drug. 15. The method of claim 1, wherein the electrical stimulation is automatically paused for a preset amount of time every 10 minutes to overcome habituation. 16. The method of claim 1, wherein the electrical stimulation is automatically paused for a preset amount of time every 10 minutes based on feedback provided by a sensor regarding target nerve stimulation or habituation. 17. The method of claim 1, wherein once tetany is detected in a patient, indicating that a threshold frequency of the applied stimulation has been reached, the strength of the applied stimulation is automatically or manually decreased. 18. The method of claim 1, wherein electrical stimulation is provided by delivering a cycle comprising a preset number of pulses followed by a pause in stimulation, followed by a preset number of pulses, and repeating the cycle as necessary. 19. The method of claim 1, wherein the pain felt by the subject is migraine pain. 20. The method of claim 19, wherein the stimulator electrode is coated with a pain relief drug. 21. The method of claim 19, wherein the stimulator electrode is a surface electrode. 22. The method of claim 19, wherein the electrical stimulation is provided by delivering a cycle comprising a preset number of pulses followed by a pause in. stimulation, followed by a preset number of pulses, and repeating the cycle as necessary. 23. The method of claim 22, wherein the electrical stimulation is delivered at a frequency of about 5 Hz to about 60 Hz. 24. The method of claim 1, further comprising providing feedback signals based on M-wave detection such that the electrical stimulation delivered through the glabrous skin surface and to a target nerve or tissue within the hand may be adjusted or optimized based on the M-wave detection. 25. The method of claim 21, further comprising providing feedback signals based on M-wave detection such that the electrical stimulation delivered through the glabrous skin surface of the palm and to a target nerve or tissue within the hand may be adjusted or optimized based on the M-wave detection.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (176)
Frazier,A. Bruno; Andrade,Joseph D.; Bartholomeusz,Daniel A.; Brazzle,John D., Active needle devices with integrated functionality.
Ameri, Mahmoud; Cormier, Michel J. N.; Maa, Yuh Fun; Kamberi, Marika; Daddona, Peter, Apparatus and method for transdermal delivery of parathyroid hormone agents.
Yuzhakov Vadim Vladimirovich ; Sherman Faiz Feisal ; Owens Grover David ; Gartstein Vladimir, Apparatus and method for using an intracutaneous microneedle array.
Schurig Janet L. S. (870 E. Walnut Ave. Provo UT 84604) Schurig Alma K. (870 E. Walnut Ave. Provo UT 84604), Brain and nerve healing power apparatus and method.
Hein Walter,DEX ; Mayer Reinhard,DEX, Device and method for aiding the positioning of an external part relative to an implantable part of a charging system for an implantable medical device.
Lastovich, Alexander G.; Fentress, James K.; Griggs, Julia; Pettis, Ronald J.; Sutter, Diane; Martin, Frank E.; Haider, M. Ishaq, Device and method for delivering or withdrawing a substance through the skin.
Lastovich,Alexander G.; Fentress,James K.; Griggs,Julia; Pettis,Ronald J.; Sutter,Diane; Martin,Frank E.; Haider,M. Ishaq, Device and method for delivering withdrawing a substance through the skin.
Howson David C. (Denver CO) Pauley J. Donald (Estes Park CO) Carroll Gary T. (Boulder CO), Device and method for precise subcutaneous placement of a medical instrument.
Prausnitz, Mark R.; Allen, Mark G.; Henry, Sebastien; McAllister, Devin V.; Ackley, Donald E.; Jackson, Thomas, Devices and methods for enhanced microneedle penetration of biological barriers.
Williams, Jeffrey M.; Van Aart, Fred; Van Den Biggelaar, Hans; van Laanen, legal representative, Petronella Maria Coleta; Van Helvoirt, Plet, Electro-nerve stimulator system and methods.
Shastri Venkatram R. ; Rahman Nahid ; Martin Ivan ; Langer ; Jr. Robert S., Electroactive materials for stimulation of biological activity of bone marrow stromal cells.
Pollack Solomon R. (Dresher PA) Brighton Carl T. (Malvern PA) Pienkowski David (Exton PA) Griffith Neil J. (San Diego CA), Electromagnetic method and apparatus for healing living tissue.
Prochazka Arthur (Edmonton CAX) Wieler Marguerite (Edmonton CAX) Kenwell Zoltan R. (Edmonton CAX) Gauthier Michel J. A. (Edmonton CAX), Garment for applying controlled electrical stimulation to restore motor function.
Meadows, Paul M.; Mann, Carla M.; Tsukamoto, Hisashi; Chen, Joey, Implantable pulse generators using rechargeable zero-volt technology lithium-ion batteries.
Mann, Carla M.; Whitehurst, Todd K.; McGivern, James P.; Loeb, Gerald E.; Richmond, Frances J. R., Implantable stimulator methods for treatment of incontinence and pain.
Loeb, Gerald E.; Richmond, Francis J. R.; Mann, Carla M.; Faltys, Michael A.; Whitehurst, Todd K.; McGivern, James P., Implantable stimulator system and method for treatment of incontinence and pain.
Hsiao,Richard D.; Le,Quang; Lee,Edward Hin Pong; Nguyen,Paul Phong; Nguyen,Son Van; Tang,Denny D.; Webb,Bradley Douglas; Webb,Patrick Rush; Yuan,Samuel Wei san, Magnetic transducer with a write head having a multi-layer coil.
Alok Sarwal ; Birinder R. Boveja, Method and apparatus for locating implanted receiver and feedback regulation between subcutaneous and external coils.
Chiou,Jin Chern; Hung,Chen Chun; Chang,Chih Wei, Method for fabricating microneedle array and method for fabricating embossing mold of microneedle array.
Sherman, Faiz Feisal; Gartstein, Vladimir, Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation.
Wood,Robert L.; Wynands,Henry A.; Markus,Karen W., Methods of fabricating microneedle arrays using sacrificial molds, and microneedle arrays fabricated thereby.
Yuzhakov, Vadim Vladimirovich; Gartstein, Vladimir; Owens, Grover David, Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup.
Delmore, Michael D.; Fleming, Patrick R.; Huntley, Douglas A.; Keister, Jamieson C.; Thomas, Cristina U.; Ferber, Richard H., Microneedle arrays and methods of manufacturing the same.
Ryaby John P. (Essex Fells NJ) Pilla Arthur A. (Wyckoff NJ), Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective chan.
Talish Roger J. (Fairfield NJ) Parr William E. (Denville NJ) Zavros Steven J. (Morristown NJ), Portable non-invasive electromagnetic therapy equipment.
Berlant Stephen R. (392 Marple Rd. Broomall PA 19008), Structure and method of manufacturing an electrode glove for applying electro-massage and electro-acupressure to patient.
Golubovic Liakopoulos, Nevenka; Fricano, Glenn; Danielson, Michael, System and method for drug delivery and microfluidic applications using microneedles.
King Gary W. ; Gielen Frans,NLX ; Petersen Daryle ; Rise Mark T. ; Schendel Michael ; Starkebaum Warren, Techniques for positioning therapy delivery elements within a spinal cord or a brain.
Wang Xintao (Lake Jackson TX) Munshi Mohammed Zafar Amin (Missouri City TX), Transcutaneous energy transmission circuit for implantable medical device.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.