Device and implantation system for electrical stimulation of biological systems
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/36
A61B-005/03
A61B-005/145
A61N-001/05
출원번호
US-0201766
(2014-03-07)
등록번호
US-9345879
(2016-05-24)
발명자
/ 주소
Sharma, Virender K.
Gani, Matt Joseph
Goode, Paul V.
Hogg, Bevil
Miazga, Jay
Policker, Shai
Raby, Kaila
출원인 / 주소
EndoStim, Inc.
대리인 / 주소
Novel IP
인용정보
피인용 횟수 :
0인용 특허 :
130
초록▼
The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation
The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
대표청구항▼
1. A system for treating a gastrointestinal condition of a patient, comprising: a pulse generator in electrical communication with at least one electrode, wherein said pulse generator is adapted to be implanted such that said electrode is configured to be in electrical communication with a lower eso
1. A system for treating a gastrointestinal condition of a patient, comprising: a pulse generator in electrical communication with at least one electrode, wherein said pulse generator is adapted to be implanted such that said electrode is configured to be in electrical communication with a lower esophageal sphincter (LES) of the patient, and wherein said pulse generator generates a pulse stream in accordance with a preset period;an energy storage component; anda non-volatile memory for storing programmatic code which, when executed by a processor, causes said pulse generator to generate the pulse stream for the preset period,wherein said pulse stream comprises a pulse width having a range of 30 μsec to 5 msec, a pulse amplitude having a range of 2 to 15 mAmp, a pulse frequency having a range of 2 to 80 Hz, an on period having a range of 1 second to 23 hours, 59 minutes, and 59 seconds, an off period having a range of 1 second to 23 hours, 59 minutes, and 59 seconds, and a duty cycle having a range of 1 to 100%, wherein values for each of said pulse width, pulse amplitude, and pulse frequency are defined such that swallowing of the patient is not hindered by said stimulation while said stimulation is occurring. 2. The system of claim 1, further comprising an accelerometer wherein said system includes a pre-programmed stimulation mode adapted to automatically stimulate the patient's LES during time periods in which the patient is in a supine position as determined by said accelerometer, said supine position being defined by a level of inclination relative to a vertical baseline wherein 0 degrees is a vertical position and wherein said level is programmable and has a range of 50 to 80 degrees. 3. The system of claim 2, wherein said automatic stimulation occurs after the patient has been in the supine position for a predetermined period of time and wherein said predetermined period of time is programmable and has a range of 1 minute to 60 minutes. 4. The system of claim 3, wherein said automatic stimulation occurs after a minimum percentage of data points occur within said predetermined period of time and wherein said minimum percentage of data points is programmable and has a range of 50 to 90 percent. 5. The system of claim 1, wherein said system does not have a sensor to determine when the patient is swallowing and does not modify said stimulation based on said swallowing. 6. A system for treating a gastrointestinal condition of a patient, comprising: a pulse generator in electrical communication with at least one electrode, wherein said pulse generator is adapted to be implanted such that said electrode is configured to be in electrical communication with a lower esophageal sphincter (LES) of the patient, and wherein said pulse generator generates a pulse stream;an energy storage component; andprogrammatic code which, when executed by a processor, causes said pulse generator to generate the pulse stream, wherein the programmatic code is not configured to modify the pulse stream based upon data from a sensor indicative of the patient engaging in swallowing,wherein said pulse stream comprises a pulse width having a range of 30 μsec to 5 msec, a pulse amplitude having a range of 2 to 15 mAmp, and a pulse frequency having a range of 2 to 80 Hz, wherein values for each of said pulse width, pulse amplitude, and pulse frequency are selected such that swallowing of the patient is not hindered by said stimulation while said stimulation is occurring. 7. The system of claim 6, further comprising an accelerometer wherein said system includes a pre-programmed stimulation mode adapted to automatically stimulate the patient's LES during time periods in which the patient is in a supine position as determined by said accelerometer, said supine position being defined by a level of inclination relative to a vertical baseline wherein 0 degrees is a vertical position and wherein said level is programmable and has a range of 50 to 80 degrees. 8. The system of claim 7, wherein said automatic stimulation occurs after the patient has been in the supine position for a predetermined period of time and wherein said predetermined period of time is programmable and has a range of 1 minute to 60 minutes. 9. The system of claim 8, wherein said automatic stimulation occurs after a minimum percentage of data points occur within said predetermined period of time and wherein said minimum percentage of data points is programmable and has a range of 50 to 90 percent. 10. A system for treating a gastrointestinal condition of a patient, comprising: a pulse generator in electrical communication with at least one electrode, wherein said pulse generator is adapted to be implanted such that said electrode is configured to be in electrical communication with a lower esophageal sphincter (LES) of the patient, and wherein said pulse generator generates a pulse stream;an energy storage component; andprogrammatic code which, when executed by a processor, causes said pulse generator to generate the pulse stream,wherein said pulse stream has a pulse width having a range of 30 μsec to 5 msec, a pulse amplitude having a range of 2 to 15 mAmp, and a pulse frequency having a range of 2 to 80 Hz, wherein values for at least one of said pulse width, pulse amplitude, and pulse frequency are selected such that swallowing of the patient is not hindered by said stimulation while said stimulation is occurring. 11. The system of claim 10, further comprising an accelerometer wherein said system includes a pre-programmed stimulation mode adapted to automatically stimulate the patient's LES during time periods in which the patient is in a supine position as determined by said accelerometer, said supine position being defined by a level of inclination relative to a vertical baseline wherein 0 degrees is a vertical position and wherein said level is programmable and has a range of 50 to 80 degrees. 12. The system of claim 11, wherein said automatic stimulation occurs after the patient has been in the supine position for a predetermined period of time and wherein said predetermined period of time is programmable and has a range of 1 minute to 60 minutes. 13. The system of claim 12, wherein said automatic stimulation occurs after a minimum percentage of data points occur within said predetermined period of time and wherein said minimum percentage of data points is programmable and has a range of 50 to 90 percent. 14. The system of claim 1, wherein said system does not have a sensor to determine when the patient is swallowing.
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이 특허에 인용된 특허 (130)
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Boveja, Birinder R., External pulse generator for adjunct (add-on) treatment of obesity, eating disorders, neurological, neuropsychiatric, and urological disorders.
Roline, Glenn M.; Terry, Michael B.; Roberts, Jonathan P.; Reinke, James D.; Corey, Robert A., Fault tolerant implantable pulse generators and implantable cardioverter-defibrillators incorporating physiologic sensors and methods for implementing fault tolerance in same.
Whitehurst,Todd K; McGivern,James P; Mann,Carla M, Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction.
Dinsmoor, David A.; Starkebaum, Warren L., Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof.
Chen Jian Dez (Edmond OK) McCallum Richard W. (Charlottesville VA) Williams Ronald (Charlottesville VA) Ross Robert (Charlottesville VA) Lin Zhiyue (Charlottesville VA) Tillack Jonathan (Charlottesvi, Gastro-intestinal pacemaker having phased multi-point stimulation.
Houben,Richard P. M.; Christopherson,Mark A.; Donders,Adrianus P.; Leinders,Robert; Deno,Curtis D., Implantable lead-based sensor powered by piezoelectric transformer.
Schulman Joseph H. (Santa Clarita CA) Loeb Gerald E. (Kingston CAX) Gord John C. (Venice CA) Strojnik Primoz (Granada Hills CA), Implantable microstimulator.
Strother, Robert B.; Mrva, Joseph J.; Thrope, Geoffrey B., Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue.
Foley, Stephen T., Method and apparatus for intentional impairment of gastric motility and/or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity.
DiLorenzo, Daniel John, Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease.
Knudson, Mark B.; Wilson, Richard R.; Tweden, Katherine S.; Conrad, Timothy R., Nerve stimulation and blocking for treatment of gastrointestinal disorders.
Douglas Donald D. (2009 Madison Ave. Lewisburg PA 17837), Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system.
Cigaina Valerio (Via 4 Novembre 3a 31050 Villorba (Treviso) ITX), Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient.
Goetz, Steven M.; Stone, Richard T.; Ball, Warren W.; Wahlstrand, Carl D., Programming interface with a concentric axial view of a stimulation lead with complex electrode array geometry.
Goetz, Steven M.; Stone, Richard T.; Ball, Warren W.; Wahlstrand, Carl D., Programming interface with a cross-sectional view of a stimulation lead with complex electrode array geometry.
Goetz, Steven M.; Houchins, Andrew H.; Keacher, Jeffrey T.; King, Gary W.; Heruth, Kenneth T.; Testerman, Roy L.; Lee, Michael T.; Torgerson, Nathan A.; Nolan, Joseph J., Shifting between electrode combinations in electrical stimulation device.
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Buschman, Hendrik Peter Johan; Burnes, John Edward; Cornelussen, Richard N. M.; Hill, Michael Roland Scott; Kornet, Lilian; Ordelman, Simone Cornelia Maria Anna; Veltink, Petrus Hermanus, Therapy using perturbation and effect of physiological systems.
Buschman, Hendrik Peter Johan; Burnes, John Edward; Cornelussen, Richard N. M.; Hill, Michael Roland Scott; Kornet, Lilian; Ordelman, Simone Cornelia Maria Anna; Veltink, Petrus Hermanus, Therapy using perturbation and effect of physiological systems.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX) Marquette Andre (Stamford CT), Treatment of motility disorders by nerve stimulation.
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