In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the v
In certain embodiments, a vial adaptor comprises a housing member, a connector configured to couple the adaptor with a vial, and an extractor channel formed in the housing member. The extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. In some embodiments, an anti-reflux valve is positioned within the extractor channel. The anti-reflux valve can be configured to impede or obstruct fluid returning to a fluid source after withdrawal of the fluid from the fluid source.
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1. A vial adaptor comprising: a housing member;a connector configured to couple the housing member with a vial;an extractor channel formed in the housing member, wherein the extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial;a regu
1. A vial adaptor comprising: a housing member;a connector configured to couple the housing member with a vial;an extractor channel formed in the housing member, wherein the extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial;a regulator channel formed in the housing member configured to permit regulating fluid to flow into or out of the vial when fluid flows through the extractor channel;a regulating enclosure in fluid communication with the regulator channel, wherein the regulating enclosure is configured to move between a first orientation in which at least a portion of the regulating enclosure is at least partially unexpanded or folded and a second orientation in which at least a portion of the enclosure is at least partially expanded or unfolded when a medicinal fluid is withdrawn from the vial via the extractor channel; andan anti-reflux valve positioned within the extractor channel, wherein the anti-reflux valve has a first cracking pressure for allowing fluid flow into the vial and a second cracking pressure for allowing fluid flow out of the vial, and wherein the anti-reflux valve is configured to impede or obstruct fluid flow into the vial after withdrawal of at least some of the fluid from the vial unless the first cracking pressure is met;wherein the anti-reflux valve comprises: a flow regulator having a threshold pressure equal to the second cracking pressure for multiple directions of fluid flow, and wherein the flow regulator is configured to open and permit fluid flow when fluid having a pressure of at least the threshold pressure pushes against the flow regulator; anda threshold pressure adjustor disposed adjacent to the flow regulator, wherein the threshold pressure adjustor comprises a blocking structure, and wherein the threshold pressure adjustor is configured to change the threshold pressure of the flow regulator in one or more directions of fluid flow to be equal to the first cracking pressure. 2. The vial adaptor of claim 1, further comprising a sheath extending from the housing member, the sheath configured to be positioned within the vial when the adaptor is coupled to the vial. 3. The vial adaptor of claim 2, wherein the regulating enclosure comprises a bag housed at least partially within the sheath, the bag configured to expand in response to pressure changes within the vial as fluid is withdrawn from the vial. 4. The vial adaptor of claim 1, wherein the regulator channel is configured to provide fluid communication between ambient air and the regulating enclosure. 5. The vial adaptor of claim 1, further comprising a medical connector interface extending from the housing member, the medical connector interface configured to connect the adaptor to a medical connector. 6. The vial adaptor of claim 5, wherein the medical connector interface defines a proximal portion of the extractor channel, and wherein the anti-reflux valve is positioned within the proximal portion of the extractor channel. 7. The vial adaptor of claim 1, wherein the anti-reflux valve is further configured to permit fluid to be withdrawn from a vial more easily than for fluid to be added to the vial. 8. The vial adaptor of claim 7, wherein the first cracking pressure is greater than the second cracking pressure. 9. The vial adaptor of claim 1, wherein the anti-reflux valve comprises a component selected from the group consisting of membranes, gaskets, check valves, two-way valves, self-sealing valves, and duckbill valves. 10. The vial adaptor of claim 1, wherein the anti-reflux valve comprises a dome-shaped valve. 11. The vial adaptor of claim 1, wherein the anti-reflux valve comprises: a cup having a base with an opening formed therein; anda blocking structure disposed adjacent to the base of the cup, the blocking structure configured to obstruct at least a portion of the opening. 12. The vial adaptor of claim 11, wherein the blocking structure comprises a washer. 13. The vial adaptor of claim 11, wherein the blocking structure is disposed upstream from the cup when fluid is withdrawn from the vial via the extractor channel. 14. The vial adaptor of claim 1, wherein a fluid-tight seal exists between the anti-reflux valve and a sidewall of the extractor channel. 15. The vial adaptor of claim 1, wherein: the flow regulator comprises a cup that is generally cylindrical and shaped to fit within the extractor channel, wherein the cup comprises a substantially planar base that forms a barrier to fluid flow within the extractor channel; andthe threshold pressure adjustor comprises a washer disposed on the end of the cup that faces towards the vial;wherein the base of the cup comprises an opening formed through the base, wherein the opening follows a substantially straight line across a diameter of the base, and wherein the opening has a length slightly less than the width of the diameter of the base; andwherein the washer comprises a thin cylindrical body having a hole formed therein, the hole having a diameter width that is less than the length of the opening. 16. The vial adaptor of claim 15, wherein the cup further comprises a wall portion that extends from the base in a direction away from the vial, the wall portion configured to prevent a medical connector from interfering with the operation of the anti-reflux valve by keeping the medical connector away from the opening. 17. The vial adaptor of claim 15, wherein the washer is configured to limit the length of the opening that is allowed to deflect towards the washer when fluid flows into the vial, such that the opening is configured to deflect along a greater length in one direction of fluid flow than in another direction of fluid flow. 18. A method of regulating fluid flow through a vial adaptor, the method comprising: providing a housing member configured to couple with a vial;permitting fluid to flow through an extractor channel formed in the housing member, the extractor channel configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial; andregulating fluid flow within the extractor channel such that fluid does not flow into the vial unless a first cracking pressure is exceeded;wherein the first cracking pressure is greater than a second cracking pressure, the second cracking pressure being a fluid pressure at which fluid is permitted to flow when fluid is withdrawn from the vial;wherein regulating fluid flow within the extractor channel comprises: directing fluid through a flow regulator having a threshold pressure equal to the second cracking pressure for multiple directions of fluid flow, wherein the flow regulator is configured to open and permit fluid flow when fluid having a pressure of at least the threshold pressure pushes against the flow regulator; anddirecting fluid through a threshold pressure adjustor disposed adjacent to the flow regulator, wherein the threshold pressure adjustor comprises a blocking structure, and wherein the threshold pressure adjustor is configured to change the threshold pressure of the flow regulator in one or more directions of fluid flow to be equal to the first cracking pressure. 19. The method of claim 18, further comprising regulating pressure in the vial to be substantially steady as fluid is withdrawn from the vial. 20. A method of manufacturing a vial adaptor, the method comprising: providing a housing member having an extractor channel, a regulator channel, and a connector configured to couple the housing member with a vial, wherein the extractor channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial, and wherein the regulator channel is configured to permit regulating fluid to flow into or out of the vial when fluid flows through the extractor channel;positioning an anti-reflux valve within the extractor channel, wherein the anti-reflux valve has a first cracking pressure for allowing fluid flow into the vial and a second cracking pressure for allowing fluid flow out of the vial, and wherein the anti-reflux valve is configured to impede or obstruct fluid flow into the vial after withdrawal of at least some of the fluid from the vial unless the first cracking pressure is met; anddisposing a regulating enclosure in fluid communication with the regulator channel, wherein the regulating enclosure is configured to move between a first orientation in which at least a portion of the regulating enclosure is at least partially unexpanded or folded and a second orientation in which at least a portion of the enclosure is at least partially expanded or unfolded when a medicinal fluid is withdrawn from the vial via the extractor channelwherein the anti-reflux valve comprises: a flow regulator having a threshold pressure equal to the second cracking pressure for multiple directions of fluid flow, and wherein the flow regulator is configured to open and permit fluid flow when fluid having a pressure of at least the threshold pressure pushes against the flow regulator; anda threshold pressure adjustor disposed adjacent to the flow regulator, wherein the threshold pressure adjustor comprises a blocking structure, and wherein the threshold pressure adjustor is configured to change the threshold pressure of the flow regulator in one or more directions of fluid flow to be equal to the first cracking pressure. 21. The method of claim 20, wherein the regulating enclosure comprises a bag disposed at least partially within a sheath extending from the housing member, wherein the sheath is configured to be positioned within the vial when the adaptor is coupled to the vial and the bag is configured to expand in response to pressure changes within the vial as fluid is withdrawn from the vial. 22. The method of claim 20, wherein positioning the anti-reflux valve comprises: positioning a blocking structure within the extractor channel; anddisposing a cup having a base with an opening formed therein within the extractor channel such that the base is adjacent to the blocking structure;wherein the blocking structure is configured to obstruct at least a portion of the opening. 23. The method of claim 20, wherein positioning the anti-reflux valve comprises creating a fluid-tight seal between the anti-reflux valve and a sidewall of the extractor channel.
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