Ventilation circuit adaptor and proximal aerosol delivery system
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-016/14
A61M-016/08
A61M-015/00
A61M-011/00
A61M-016/10
A61M-016/16
A61M-016/00
A61M-016/20
출원번호
US-0180004
(2014-02-13)
등록번호
US-9352114
(2016-05-31)
발명자
/ 주소
Mazela, Jan
Henderson, Christopher
출원인 / 주소
Windtree Therapeutics, Inc.
대리인 / 주소
Caesar Rivise, PC
인용정보
피인용 횟수 :
0인용 특허 :
68
초록▼
An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient inter
An adaptor for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation includes an aerosol flow channel having an aerosol inlet port and a patient interface port, and defining an aerosol flow path from the aerosol inlet port to and through the patient interface port; and a ventilation gas flow channel in fluid communication with the aerosol flow channel and having a gas inlet port and a gas outlet port, and defining a ventilation gas flow path from the gas inlet port to and through the gas outlet port, wherein the ventilation gas flow path is at least partially offset from the aerosol flow path and at least partially encircles the aerosol flow path. Systems and methods for delivering an aerosolized active agent to a patient with concomitant positive pressure ventilation incorporate the adaptor.
대표청구항▼
1. A ventilation circuit adaptor for providing ventilation gas and aerosol, the adaptor having an aerosol flowpath and a ventilation gas flowpath, the adaptor comprising: (a) an aerosol flow chamber having a wall, the aerosol flow chamber extending along a longitudinal axis from an aerosol flow cham
1. A ventilation circuit adaptor for providing ventilation gas and aerosol, the adaptor having an aerosol flowpath and a ventilation gas flowpath, the adaptor comprising: (a) an aerosol flow chamber having a wall, the aerosol flow chamber extending along a longitudinal axis from an aerosol flow chamber inlet port to a patient interface port;(b) an aerosol flow channel disposed within the aerosol flow chamber, the aerosol flow channel having a longitudinal axis coaxial with the longitudinal axis of the aerosol flow chamber, the aerosol flow channel having a wall and extending from an aerosol flow channel inlet port to an aerosol flow channel outlet port, wherein the aerosol flow channel outlet port is in fluid communication with the patient interface port, wherein the aerosol flow channel inlet port is sealingly connected to the aerosol flow chamber, wherein an annular zone is provided and bounded by the wall of the aerosol flow channel and the wall of the aerosol flow chamber, the annular zone being in fluid communication with the patient interface port, such that the aerosol flowpath extends from the aerosol flow chamber inlet port, through the aerosol flow channel, and out the patient interface port; and(c) a ventilation gas flow chamber extending from a ventilation gas inlet port through the wall in the aerosol flow chamber, through and in fluid communication with the annular zone and the patient interface, and through the wall in the aerosol flow chamber and to a ventilation gas outlet port, such that the ventilation gas flowpath extends from the ventilation gas inlet port, and through the annular zone to the ventilation gas outlet port. 2. The adaptor of claim 1, further comprising a valve at the aerosol flow chamber inlet port. 3. The adaptor of claim 2, wherein the valve is sufficiently flexible to allow introduction of at least one of an instrument, a catheter, a tube, or a fiber into and through at least one of the aerosol flow channel and the patient interface port, while maintaining positive ventilatory pressure. 4. The adaptor of claim 1, wherein the aerosol flow channel defines a substantially straight aerosol flow path. 5. The adaptor of claim 1, wherein the aerosol flow channel has a greater cross sectional area at the aerosol flow channel inlet port than at the patient interface port. 6. The adaptor of claim 1, wherein fluid communication between the aerosol flow channel and the ventilation gas flow channel occurs via at least one aperture. 7. The adaptor of claim 1, wherein the aerosol flow channel extends from the aerosol flow channel inlet port through the ventilation gas flow channel chamber to the aerosol flow channel and is recessed from the patient interface port at the opposite end of the ventilation gas flow channel chamber, wherein the aerosol flow channel is of a sufficient length to extend beyond the ventilation gas inlet port and the ventilation gas outlet port. 8. The adaptor of claim 7, wherein the aerosol outlet port is recessed from the patient interface port by at least 8 millimeters. 9. The adaptor of claim 7, wherein the ventilation gas flow channel chamber has a volume between the aerosol outlet port and the patient interface port of at least 1.4 milliliters. 10. The adaptor of claim 7, further comprising a one-way valve at the aerosol outlet port. 11. The adaptor of claim 1, wherein the aerosol flow channel inlet port is sealingly connected to the wall of the aerosol flow chamber by a funnel-shaped flange. 12. The adaptor of claim 1, wherein the aerosol flow channel inlet port is sealingly connected to the wall of the aerosol flow chamber by an annular flange that is perpendicular to the longitudinal axis of the aerosol flow chamber. 13. The adaptor of claim 1, wherein the aerosol flow channel inlet port is recessed longitudinally within the aerosol flow chamber. 14. The adaptor of claim 1, wherein the aerosol flow channel has a substantially uniform cross-sectional area. 15. A system for delivering a propelled aerosolized active agent with concomitant positive pressure ventilation to a patient, comprising: a positive pressure ventilation circuit comprising a positive pressure generator for producing a pressurized ventilation gas, a first delivery conduit for delivering the pressurized ventilation gas to the patient and a second delivery conduit for directing a flow of exhalation gas from the patient;an aerosol generator for producing an aerosolized active agent;a patient interface for delivering the ventilation gas and the aerosolized active agent to the patient;a ventilation circuit adaptor of claim 1 in communication with the positive pressure ventilation circuit, the aerosol generator and the patient interface;an aerosol entrainment chamber adapted to produce the propelled aerosolized active agent, wherein the aerosol entrainment chamber is in communication with the aerosol generator; andan auxiliary circuit in connection with the first delivery conduit for delivering the pressurized ventilation gas to the patient, wherein the auxiliary circuit comprises a first auxiliary conduit connecting the first delivery conduit and the aerosol entrainment chamber and, optionally, a second auxiliary conduit connecting the aerosol entrainment chamber and the aerosol inlet port of the ventilation circuit adaptor,wherein the first auxiliary conduit is adapted to accommodate a portion of the pressurized ventilation gas which is removed from a main flow of the pressurized ventilation gas directed toward the ventilation circuit adaptor to be used as a sheath gas for delivery of propelled aerosolized active agent, and to deliver the portion of the pressurized ventilation gas to the aerosol entrainment chamber for combining with the aerosolized active agent to form the propelled aerosolized active agent. 16. The system of claim 15, wherein the aerosol entrainment chamber is directly connected with the aerosol flow chamber inlet port of the adaptor. 17. The system of claim 15, wherein the auxiliary circuit comprises a connector adapted to measure out the portion of the pressurized ventilation gas based on the patient's peak inspiratory flow. 18. The system of claim 15, wherein the auxiliary circuit further comprises a flow restrictor adapted to regulate a flow of the sheath gas such that the flow of the sheath gas is equal to or higher than the patient's peak inspiratory flow. 19. The system of claim 15, wherein the second auxiliary conduit is added to connect the aerosol entrainment chamber and the aerosol flow chamber inlet port of the adaptor.
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