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An access port for introduction of a needle cannula tip into an IV tube set includes a rigid tubular housing and a resilient member disposed within an inlet of the housing. The resilient member includes a proximal face exposed to an exterior of the rigid housing and a distal face disposed within the

An access port for introduction of a needle cannula tip into an IV tube set includes a rigid tubular housing and a resilient member disposed within an inlet of the housing. The resilient member includes a proximal face exposed to an exterior of the rigid housing and a distal face disposed within the rigid housing. An axial perforation extends through the resilient member, and is normally closed by a resilient character of the resilient member. A depression is defined in the proximal face of the resilient member, and includes sidewalls extending between the proximal face and the axial perforation to guide the needle cannula tip toward the axial perforation as a needle cannula associated with the needle cannula tip is introduced into the access port.

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1. A resilient member comprising: a resilient body defining: a distal face and a proximal face opposite the distal face, a longitudinal axis of the resilient body defined perpendicular to and between the proximal and distal faces;an axial perforation extending through the resilient body, the axial p

1. A resilient member comprising: a resilient body defining: a distal face and a proximal face opposite the distal face, a longitudinal axis of the resilient body defined perpendicular to and between the proximal and distal faces;an axial perforation extending through the resilient body, the axial perforation normally closed by a resiliency of the resilient body; anda depression defined in the proximal face, the depression being defined by first and second sidewalls extending between the proximal face and the axial perforation, the first and second sidewalls including both an axial and a radial component such that the first and second sidewalls are configured to guide a needle cannula tip toward the axial perforation, the first and second sidewalls being generally straight and intersecting the axial perforation to define a V-shaped trough, the first sidewall disposed at an angle α with respect to an axis perpendicular to the longitudinal axis of the resilient body and the second sidewall disposed at an angle γ with respect to the longitudinal axis of the resilient body such that the first sidewall and the second sidewall define different angles with respect to the longitudinal axis of the resilient body, the first sidewall configured to engage a cutting edge of the needle cannula tip and the second sidewall configured to engage a bevel of the needle cannula tip to align the cutting edge of the needle cannula tip with the axial perforation. 2. The resilient member according to claim 1, wherein the resilient body includes an elastomeric material. 3. The resilient member according to claim 1, wherein the axial perforation defines a generally straight slit extending distally to the distal face of the resilient body. 4. The resilient member according to claim 1, wherein the angle α is in a range of 5° to 45°. 5. The resilient member according to claim 1, wherein the angle γ is in a range of 5° to 25°. 6. A valve, comprising: a resilient body defining a longitudinal axis and having a distal face and a proximal face opposite the distal face, the distal and proximal faces extending generally orthogonal to the longitudinal axis, the resilient body defining an axial perforation extending through the distal and proximal faces of the resilient body, the axial perforation normally closed under an influence of a resiliency of the resilient body, the proximal face having first and second sidewalls extending to the axial perforation, the first and second sidewalls including both an axial and a radial component such that the first and second sidewalls are sloped toward the axial perforation, the first and second sidewalls being generally straight and intersecting the axial perforation to define a V-shaped trough, the first sidewall disposed at an angle α with respect to an axis perpendicular to the longitudinal axis of the resilient body and the second sidewall disposed at an angle γ with respect to the longitudinal axis of the resilient body such that the first sidewall and the second sidewall define different angles with respect to the longitudinal axis of the resilient body, wherein at least one of the first and second sidewalls is configured to engage a needle cannula tip to align a cutting edge of the needle cannula tip with the axial perforation. 7. The valve according to claim 6, wherein the first sidewall is configured to engage the cutting edge of the needle cannula tip to align the cutting edge of the needle cannula tip with the axial perforation. 8. The valve according to claim 6, wherein the second sidewall is configured to engage a bevel of the needle cannula tip to align the cutting edge of the needle cannula tip with the axial perforation. 9. The valve according to claim 6, wherein the angle α is in a range of 5° to 45°. 10. The valve according to claim 6, wherein the angle γ is in a range of 5° to 25°. 11. A method of administering an injectable pharmaceutical, the method comprising: penetrating a septum of a first resilient member of a vial of with a slanted cutting edge disposed at a distal end of a tip member of a needle cannula and inserting the tip member of the needle cannula into the injectable pharmaceutical contained within the vial;withdrawing the injectable pharmaceutical from the vial into a lumen extending through the needle cannula;withdrawing the tip member of the needle cannula from the vial;approximating the tip member of the needle cannula with a second resilient member of a prepierced access port in fluid communication with an IV tube set until the tip member abuts at least one of a first sidewall and a second sidewall of a depression of the second resilient member; andadvancing the tip member axially against the at least one of the first sidewall and the second sidewall of the depression to guide the tip member radially toward an axial perforation of the second resilient member and to align the slanted cutting edge of the needle cannula with the axial perforation of the second resilient member. 12. The method according to claim 11, wherein aligning the slanted cutting edge of the needle cannula with the axial perforation of the second resilient member includes engaging the first sidewall disposed at an angle α with the slanted cutting edge, the slanted cutting edge disposed at the angle α. 13. The method according to claim 11, wherein aligning the slanted cutting edge of the needle cannula with the axial perforation of the second resilient member includes engaging a bevel on an outer lateral surface of the tip member disposed at an angle γ with the second sidewall, the second sidewall disposed at the angle γ. 14. The method according to claim 11, further comprising: inserting the tip member through the axial perforation; andinjecting the injectable pharmaceutical from the lumen of the needle cannula into the IV tube set. 15. The method according to claim 11, further comprising forming a seal around the needle cannula with the axial perforation of the second resilient member when the tip member of the needle cannula is inserted through the axial perforation. 16. The method according to claim 11, wherein approximating the tip member of the needle cannula with the second resilient member includes seating the tip member within the depression by cooperation of the slanted cutting edge with an angle α of the first sidewall and a bevel with an angle γ of the second sidewall to provide a tactile queue when the tip member is seated. 17. The method according to claim 11, wherein penetrating the septum of the first resilient member of the vial with the slanted cutting edge includes aligning the slanted cutting edge of the needle cannula with an axial perforation of the septum. 18. The method according to claim 17, wherein aligning the slanted cutting edge of the needle cannula with the axial perforation of the septum includes engaging a first sidewall of the septum disposed at an angle α with the slanted cutting edge, the slanted cutting edge disposed at the angle α. 19. The method according to claim 17, wherein aligning the slanted cutting edge of the needle cannula with the axial perforation of the septum includes engaging a bevel on an outer lateral surface of the tip member disposed at an angle γ with a second sidewall of the septum, the second sidewall of the septum disposed at the angle γ.