Kit for multifunctional compounds forming crosslinked biomaterials
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/02
C08G-065/00
A61L-031/16
A61L-027/54
A61K-009/00
A61K-009/16
A61F-002/44
A61F-002/30
A61K-038/00
출원번호
US-0918528
(2013-06-14)
등록번호
US-9353218
(2016-05-31)
발명자
/ 주소
Daniloff, George Y.
Ngo, Michael Huy
Trollsas, Olof Mikael
Gravett, David M.
Toleikis, Philip M.
출원인 / 주소
Angiotech Pharmaceuticals, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
171
초록▼
Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial env
Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
대표청구항▼
1. A kit for use in medical applications, comprising: a. a plurality of multifunctional compounds, each compound having the structure of formula (I): wherein:n is an integer from 1-12, and when n is 2-12, each Z component may be different;R is selected from hydrophilic polymers, hydrophobic polymers
1. A kit for use in medical applications, comprising: a. a plurality of multifunctional compounds, each compound having the structure of formula (I): wherein:n is an integer from 1-12, and when n is 2-12, each Z component may be different;R is selected from hydrophilic polymers, hydrophobic polymers, amphiphilic polymers, C2-14 hydrocarbyls, and heteroatom-containing C2-14 hydrocarbyls;X, Y, and Z are reactive groups and can be the same or different, wherein the reactive groups are selected from nucleophilic groups, electrophilic groups, redox groups, oxidative coupling reactive groups, photoinitiated reactive groups, and temperature-sensitive groups;L1, L2, and L3 are linking groups; andp, q, and r are integers from 0-1;wherein each reactive group is capable of reacting with at least one other reactive group, and wherein the compound is essentially non-reactive in an initial environment but is rendered reactive upon exposure to a modification in the initial environment that provides a modified environment such that a plurality of the multifunctional compounds inter-react in the modified environment to form a three-dimensional matrix;b. a first buffer solution having a pH within the range of about 1.0 to 5.5; andc. a second buffer solution having a pH within the range of about 6.0 to 11.0,wherein each component is packaged separately and admixed immediately prior to use. 2. A kit for use in medical applications, comprising: a. a plurality of multifunctional compounds, each compound having the structure of formula (I): wherein:n is an integer from 1-12, and when n is 2-12, each Z component may be different;R is selected from hydrophilic polymers, hydrophobic polymers, amphiphilic polymers, C2-14 hydrocarbyls, and heteroatom-containing C2-14 hydrocarbyls;X, Y, and Z are reactive groups and can be the same or different, wherein the reactive groups are selected from nucleophilic groups, electrophilic groups, redox groups, oxidative coupling reactive groups, photoinitiated reactive groups, and temperature-sensitive groups;L1, L2, and L3 are linking groups; andp, q, and r are integers from 0-1;wherein each reactive group is capable of reacting with at least one other reactive group, and wherein the compound is essentially non-reactive in an initial environment but is rendered reactive upon exposure to a modification in the initial environment that provides a modified environment such that a plurality of the multifunctional compounds inter-react in the modified environment to form a three-dimensional matrix;b. a first buffer solution having a pH within the range of about 1.0 to 5.5; andc. a second buffer solution having a pH within the range of about 6.0to 11.0, wherein each component is packaged separately and admixed immediately prior to use, and wherein the nucleophilic groups are amino groups and the electrophilic groups are amine-reactive groups. 3. The kit of claim 2, wherein the amine-reactive groups are selected from carboxylic acid esters, acid chloride groups, anhydrides, ketones, aldehydes, halo, isocyanato, thioisocyanato, epoxides, activated hydroxyl groups, olefins, carboxyl, succinimidyl ester, sulfosuccinimidyl ester, maleimido, epoxy, and ethenesulfonyl. 4. The kit of claim 1, wherein the nucleophilic groups are sulfhydryl groups and the electrophilic groups are sulfhydryl-reactive groups are selected so as to form a thioester, imido-thioester, thioether, or disulfide linkage upon reaction with the sulfhydryl groups. 5. The kit of claim 4 wherein the sulfhydryl-reactive groups form a disulfide linkage and have the structure —S—S—Ar where Ar is a substituted or unsubstituted nitrogen-containing heteroaromatic moiety or a non-heterocyclic aromatic group substituted with an electron- withdrawing moiety. 6. The kit of claim 4 wherein the sulfhydryl-reactive groups form a thioether linkage and are selected from maleimido, substituted maleimido, haloalkyl, epoxy, imino, aziridino, olefins, and α,β-unsaturated aldehydes and ketones. 7. A kit for use in medical applications, comprising: d. a plurality of multifunctional compounds, each compound having the structure of formula (I): wherein:n is an integer from 1-12, and when n is 2-12, each Z component may be different;R is selected from hydrophilic polymers, hydrophobic polymers, amphiphilic polymers, C2-14 hydrocarbyls, and heteroatom-containing C2-14 hydrocarbyls;X, Y, and Z are reactive groups and can be the same or different, wherein the reactive groups are selected from nucleophilic groups, electrophilic groups, redox groups, oxidative coupling reactive groups, photoinitiated reactive groups, and temperature-sensitive groups;L1, L2, and L3 are linking groups; andp, q, and r are integers from 0-1;wherein each reactive group is capable of reacting with at least one other reactive group, and wherein the compound is essentially non-reactive in an initial environment but is rendered reactive upon exposure to a modification in the initial environment that provides a modified environment such that a plurality of the multifunctional compounds inter-react in the modified environment to form a three-dimensional matrix;e. a first buffer solution having a pH within the range of about 1.0 to 5.5; andf. a second buffer solution having a pH within the range of about 6.0 to 11.0,wherein each component is packaged separately and admixed immediately prior to use, and wherein the reactive groups are selected from reactive groups that a) undergo an oxidation-reduction reaction and are vinyl groups, b) are oxidative coupling reactive groups and are halo groups, with an adjacent electron-withdrawing group on the halogen-bearing carbon, c) are photoinitiated reactive groups and are selected from azide, alkyl, and benzophenone, and d) are temperature sensitive groups and are vinyl groups. 8. The kit of claim 1, wherein R is a hydrophilic polymer. 9. The kit of claim 8, wherein the hydrophilic polymer is a linear, branched, dendrimeric, hyperbranched, or star polymer. 10. The kit of claim 9, wherein the hydrophilic polymer is selected from polyalkylene oxides; polyols; poly(oxyalkylene)-substituted diols and polyols; polyoxyethylated sorbitol; polyoxyethylated glucose; poly(acrylic acids) and analogs and copolymers thereof; polymaleic acids; polyacrylamides; poly(olefmic alcohols); poly(N-vinyl lactams); polyoxazolines; polyvinylamines; and copolymers thereof. 11. The kit of claim 10, wherein the hydrophilic polymer is a poly(oxyalkylene)-substituted polyol selected from mono-, di- and tri-polyoxyethylated glycerol, mono- and di-polyoxyethylated propylene glycol, and mono- and di- polyoxyethylated trimethylene glycol, and tetra(oxyethylene)pentaerythritol. 12. The kit of claim 1, wherein prior to use, each component is in a separate sterile package. 13. The kit of claim 1, further comprising a delivery device. 14. The kit of claim 13, wherein the delivery device is a multi-compartment device. 15. The kit of claim 14, wherein the multi-component device is a multiple-compartment syringe system having multiple barrels, a mixing head, and an exit orifice. 16. The kit of claim 15, wherein the multifunctional compound, the first buffer solution, and the second buffer solution are housed separately in the multiple-component syringe system.
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이 특허에 인용된 특허 (171)
Cooper Kevin (Warren NJ) Scopelianos Angelo (Whitehouse Station NJ), Absorbable polyalkylene diglycolates.
Fox Adrian S. (New Windsor NY) Czap Christine A. (Montgomery NY) Wiser Robin R. (Chester NY), Adhesive hydrogels having extended use lives and process for the preparation of same.
Yeung Jeffrey E. (San Jose CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Rhee Woonza M. (Palo Alto CA), Anti-adhesion films and compositions for medical use.
Silver Frederick A. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Birk David E. (Somerset NJ) Weadock Kevin (Piscataway NJ) Whyne Conrad (Somerset NJ), Biodegradable matrix and methods for producing same.
Siiman Olavi (Davie FL) Burshteyn Alexander (Miami Lakes FL) Gupta Ravinder K. (Pembroke Pines FL), Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes f.
Juergensen Kay (Murten CHX) Aeschlimann Daniel (Basel CHX) Hunziker Ernst B. (Riedholz CHX), Biological adhesive composition and method of promoting adhesion between tissue surfaces.
Kelman Charles D. (New York NY) Devore Dale P. (Chelmsford MA), Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom.
Deibig Heinrich (Frankfurt am Main Schwalbach DEX) Heide Helmut (Schwalbach DEX) Reiner Roland (Eschborn DEX) Koster Kari (Lorsbach DEX), Bone replacement or prosthesis anchoring material.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA), Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications.
Miyata Teruo (Tokyo NJ JPX) Rubin Albert L. (Englewood NJ) Stenzel Kurt H. (Englewood NJ) Dunn Michael W. (New Rochelle NY), Collagen drug delivery device.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Harner Carol F. H. (Redwood Shores CA) Sakai Naomi (San Mateo CA) Schroeder Jacqu, Collagen-based bioadhesive compositions.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Stol Miroslav (Prague CSX) Tolar Miroslav (Prague CSX) Adam Milan (Prague CSX) Cefelin Pavel (Prague CSX) Kalal Jaroslav (Prague CSX), Composite polymeric material for biological and medical application and the method for its preparation.
Shalaby Shalaby W. (Lebanon NJ) Stephenson Martin (Peterborough CAX) Schaap Louise (Peterborough CAX) Hartley ; deceased Graham H. (late of Peterborough CAX By Marilyn Hartley ; personal representati, Composite sutures of silk and hydrophobic thermoplastic elastomers.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Composition for bone repair.
Palefsky Howard (Atherton CA) Pharriss Bruce B. (Palo Alto CA) Chu George (Cupertino CA), Composition of low type III content human placental collagen.
Olof Mikael Trollsas ; Donald G. Wallace ; Frank A. DeLustro, Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use.
Donald G. Wallace ; George H. Chu ; Jacqueline Anne Schroeder, Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use.
Shadle Paula J. (Richmond CA) Koths Kirston E. (El Cerrito CA) Moreland Margaret (Berkeley CA) Katre Nandini (El Cerrito CA), Conjugation of polymer to colony stimulating factor-1.
Braatz James A. (Rockville MD) Kehr Clifton L. (Silver Spring MD), Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers.
Soon-Shiong Patrick (Los Angeles CA) Desai Neil P. (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha A. (Los Angeles CA) Sojomihardjo Soebianto (Pasadena CA), Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor.
Cartmell James V. (Xenia) Sturtevant Wayne R. (Centerville) Wolf Michael L. (West Milton) Allaire Michael J. (Cincinnati OH), High absorbency hydrogel wound dressing.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Wilk Peter J. (185 W. End Ave. New York NY 10023) Cinberg James Z. (167 N. Ridgewood Rd. South Orange NJ 07079), Method and surgical instrument for repairing hernia.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of augmenting tissue with collagen-polymer conjugates.
Mosbach Klaus H. (Furulund SEX) Nilsson Kurt G. I. (Lund SEX), Method of covalently binding biologically active organic substances to polymeric substances.
Nesburn Anthony B. (Malibu CA) Gorin Michael (Rockville MD) Martinez Marvin (Glendale CA) Kenney M. Cristina (Malibu CA) Maguen Ezra (Los Angeles CA), Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers.
Burgess, Willson H.; Greisler, Howard P.; Drohan, William N.; Maciag, Thomas; MacPhee, Martin J., Method of preparing a tissue sealant-treated biomedical material.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Rhee Woonza M. ; Rao Prema R. ; Chu George H. ; DeLustro Frank A. ; Harner Carol F. H. ; Sakai Naomi ; Schroeder Jacqueline A., Method of preventing formation of adhesions following surgery.
Franz Helmut (Biberach DEX) Muller Thomas (Biberach DEX) Eisert Wolfgang (Biberach DEX), Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydrox.
Sehl, Louis C.; Trollsas, Olof Mikael; Wallace, Donald G.; Toman, David; DeLustro, Frank A.; Schroeder, Jacqueline A.; Chu, George H., Methods for tissue repair using adhesive materials.
Wallace Donald G. (Menlo Park CA) Smestad Thomas L. (Palo Alto CA) McPherson John M. (Sunnyvale CA) Piez Karl A. (Menlo Park CA) Seyedin Saeid (Sunnyvale CA) Armstrong Rosa (Palo Alto CA), Methods of bone repair using collagen.
Jiang Ying (North Haven CT) Gruskin Elliott A. (Killingworth CT), Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom.
Cioca Gheorge (Coatesville PA) Feeley George F. (Downingtown PA) Brabson Joseph B. (Wilmington DE) Barth Peter (Neuwied DEX), Moisture vapor permeable sheet materials.
Daniloff, George Y.; Ngo, Michael Huy; Trollsas, Olof Mikael; Gravett, David M.; Toleikis, Philip M., Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use.
Luck Edward E. (216 Robin Way Menlo Park CA 94025) Daniels John R. (842 Las Casas Pacific Palisades CA 90272), Non-antigenic collagen and articles of manufacture.
Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
Constancis Alain (Lyons FRX) Soula Gerard (Meyzieu FRX), Organic products containing reactive thiol functions, one method for preparing same, and biomaterials containing said pr.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Daniels John R. (Menlo Park CA) Knapp Terry R. (Santa Clara CA), Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Schroeder Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA) F, Process for preparing a sterile, dry crosslinking agent.
Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
Carlsson Jan P. E. (Uppsala SEX) Axen Rolf E. A. V. (Balinge SEX) Drevin Hakan N. Y. (Brunna SEX) Lindgren Goran E. S. (Almunge SEX), Reactive derivatives of HS-group-containing polymers.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Lido Beach NY) Eaton Alexander M. (New York NY), Tissue bonding and sealing composition and method of using the same.
Regula Donald W. (Belle Mead NJ) Cooper Kevin (Warren NJ) Bregen Michael F. (Milford NJ) Huxel Shawn T. (Lakehurst NJ) Rosenman Daniel C. (San Mateo CA), Utilization of biocompatible adhesive/sealant materials for securing surgical devices.
Devore Dale P. (Chelmsford MA) Scherrer Robert A. (White Bear Lake MN) Scholz Matthew T. (Woodbury MN), Viscoelastic collagen solution for opthalmic use and method of preparation.
Hamilton Raymond (Somerville MA) Fox Ellen M. (Cranston RI) Acharya Raksha A. (Northboro MA) Walts Alan E. (Brookline MA), Water insoluble derivatives of hyaluronic acid.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Palo Alto CA), Xenogeneic collagen/mineral preparations in bone repair.
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