A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provide
A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
대표청구항▼
1. A delivery system for delivering substances to a surgical site comprising: a porous mesh covering comprising a biodegradable polymer, and a first compartment and a second compartment defined and formed from the mesh covering;a first substance comprising fully demineralized bone fibers provided in
1. A delivery system for delivering substances to a surgical site comprising: a porous mesh covering comprising a biodegradable polymer, and a first compartment and a second compartment defined and formed from the mesh covering;a first substance comprising fully demineralized bone fibers provided in the first compartment; anda second substance comprising surface demineralized bone chips provided in the second compartment;wherein the mesh covering retains the first substance and the second substance for placement at the surgical site and facilitates transfer of the first substance and the second substance or of surrounding materials, actively or passively through the mesh covering, upon implantation, wherein the second compartment is disposed adjacent to the first compartment, and the biodegradable polymer comprises at least one of poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and poly(lactic-co-glycolic acid) (PLGA). 2. The delivery system of claim 1, wherein the first compartment and the second compartment are separated by a barrier. 3. The delivery system of claim 1, wherein the barrier is temporary. 4. The delivery system of claim 1, wherein the first compartment and the second compartment are in communication. 5. The delivery system of claim 1, wherein the mesh covering is perforated between the first compartment and the second compartment. 6. The delivery system of claim 1, wherein at least one of the first compartments and the second compartment is unfilled at manufacture. 7. The delivery system of claim 6, wherein the at least one unfilled first compartment or second compartment comprises a port for receiving a syringe. 8. The delivery system of claim 1, wherein the first compartment is formed of a first material and the second compartment is formed of a second material and wherein the first material and the second material are not the same. 9. The delivery system of claim 8, wherein the first material and the second material have different release characteristics. 10. The delivery system of claim 1, wherein the delivery system conforms to surrounding bony contours when implanted in vivo. 11. The delivery system of claim 1, wherein the delivery system provides a pathway for healing, cell penetration and tissue ingrowth. 12. The delivery system of claim 1, wherein the mesh covering further comprises a natural material. 13. The delivery system of claim 12, wherein the natural material is collagen. 14. The delivery system of claim 1, wherein the mesh covering comprises a synthetic material. 15. The delivery system of claim 14, wherein the synthetic material is a resorbable polymeric material. 16. The delivery system of claim 1, wherein the mesh covering is treated to have particles adhered thereto. 17. The delivery system of claim 16, wherein the particles are bone particles. 18. The delivery system of claim 1, wherein the mesh covering comprises a functional material. 19. The delivery system of claim 18, wherein the functional material is radiopaque. 20. The delivery system of claim 18, wherein the functional material is bacteriocidal. 21. The delivery system of claim 1, wherein the mesh covering further comprises a reinforcing material. 22. The delivery system of claim 1, wherein the mesh covering is flexible. 23. The delivery system of claim 1, wherein the first substance and the second substance are particulated and wherein the mesh covering retains particles of the first substance and the second substance in spatial proximity to one another. 24. The delivery system of claim 1, wherein the mesh covering comprises an actively releasing material and is configured to release such material during degradation of the mesh covering. 25. The delivery system of claim 1, wherein the mesh covering controls access to an interior of the delivery system by cells. 26. The delivery system of claim 1, wherein the delivery system expands in vivo. 27. The delivery system of claim 1, wherein the delivery system is generally tubular. 28. The delivery system of claim 1, further comprising a cage, wherein the mesh covering is placed in the cage. 29. The delivery system of claim 1, further comprising an attachment mechanism. 30. The delivery system of claim 29, wherein the attachment mechanism couples the first and second compartments. 31. The delivery system of claim 29, wherein the attachment mechanism attaches the delivery system to a tissue structure. 32. The delivery system of claim 1, wherein the first substance is homogenous. 33. The delivery system of claim 1, wherein the first substance is heterogeneous. 34. The delivery system of claim 1, wherein the bone is particulated. 35. The delivery system of claim 1, wherein the bone is enhanced demineralized bone matrix. 36. The delivery system of claim 1, wherein the first substance comprises a sequence of ingredients. 37. The delivery system of claim 1, wherein the first substance exhibits a gradient. 38. The delivery system of claim 37, wherein the gradient attracts cells along a pathway. 39. The delivery system of claim 1, wherein the first substance comprises a bioactive agent. 40. The delivery system of claim 1, wherein the first substance further comprises protein, carbohydrate, lipids, collagen, allograft bone, autograft bone, TCP, hydroxyapatite, growth factors, carriers for growth factors, growth factor extracts of tissues, demineralized bone matrix, bone marrow aspirate, concentrates of lipid derived or marrow derived adult stem cells, umbilical cord derived stem cells, committed or partially committed cells from the osteogenic or chondrogenic lineage, or combinations thereof. 41. The delivery system of claim 1, wherein the delivery system comprises a ring, a cage, a generally rectangular shape, a mesh, a suture-like wrap, a continuous tube, or a plurality of strings. 42. The delivery system of claim 1, wherein the delivery system is configured for healing vertebral compression fractures, minimally invasive procedures, posterolateral fusion, correction of adult or pediatric scoliosis, treating long bone defects, osteochondral defects, ridge augmentation, or wound healing. 43. The delivery system of claim 1, wherein the delivery system is adapted to bridge more than two spinal motion segments. 44. The delivery system of claim 1, wherein the delivery system is adapted to be applied to transverse processes or spinous processes of vertebrae. 45. The delivery system of claim 1, wherein the porous mesh covering comprising a biodegradable polymer has a pore size of about 100-200 μm.
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