A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemos
A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.
대표청구항▼
1. An apparatus for subcutaneously delivering a material, comprising: an elongate delivery tube comprising first and second elongate tube members configured to move between an engaged closed position and an open position, the tube members forming the delivery tube when in the engaged closed position
1. An apparatus for subcutaneously delivering a material, comprising: an elongate delivery tube comprising first and second elongate tube members configured to move between an engaged closed position and an open position, the tube members forming the delivery tube when in the engaged closed position, the delivery tube having a chamber configured to accommodate a material therewithin, wherein the elongate tube members are flexible;an elongate pusher member having a distal portion configured to slidably extend through at least a portion of the delivery tube so as to push at least a portion of the material out of the delivery tube;an elongate catheter extending through the chamber, wherein at the distal end of the delivery tube, the chamber is just large enough to accommodate the catheter, wherein the elongate catheter comprises a stop member extending radially outwardly from a catheter surface, the stop member comprising an annular ring, wherein a coupling member is movably disposed about the elongate catheter and is configured to mechanically couple to a proximal end of the elongate pusher member, wherein the coupling member is threaded on an inner surface and is configured to engage a threaded proximal end of the elongate pusher member, such that when the coupling member and the elongate pusher member are engaged, the stop member is locked between the proximal end of the elongate pusher member and a proximal wall of the coupling member; anda flexible collar disposed about and slidable over the tube members and having a relaxed diameter less than a diameter of at least most of the delivery tube, the collar being biased to exert an inwardly-directed force on the delivery tube to hold the tube members together in the closed position so as to fit closely about the elongate catheter and to contain the material within the chamber;wherein the delivery tube generally tapers along its length, and as the delivery tube tapers in a proximal direction a diameter of the chamber increases;wherein the distal portion of the elongate pusher member is configured to fit in a proximal portion of the delivery tube; andwherein a diameter of the distal portion of the pusher member is greater than a diameter of the chamber at a point near a distal end of the delivery tube. 2. The apparatus of claim 1, wherein the flexible collar is configured as a broken ring. 3. The apparatus of claim 1, wherein both the collar and the delivery tube have smooth engaging surfaces. 4. The apparatus of claim 1, wherein a space is defined between the catheter and an inner surface of the delivery tube. 5. The apparatus of claim 1, wherein the material comprises a therapeutic agent. 6. The apparatus of claim 1, wherein the material comprises a fibrous chitosan. 7. The apparatus of claim 1, wherein when the pusher member is moved distally relative to the delivery tube, the distal portion of the pusher member engages the inner surfaces of the tube members and forces the tube members apart. 8. The apparatus of claim 7, wherein the distal portion of the pusher member is configured to contact the inner surfaces of the delivery tube at a location between about ⅔ and ¾ of the distance from the proximal end to the distal end of the chamber. 9. The apparatus of claim 1, wherein the elongate catheter is generally straight and is sized between about 4-8 F. 10. The apparatus of claim 1, wherein the first and second elongate tube members are thin-walled. 11. An apparatus for subcutaneously delivering a material, comprising: first and second elongate tube members each having first and second surfaces, the first and second elongate tube members being configured to selectively engage one another, the first and second elongate tube members defining an elongate delivery tube when engaged, the delivery tube having a delivery tube outer surface comprising the first and second elongate tube member first surfaces, the delivery tube having a first delivery tube diameter at a first point along its length and a second delivery tube diameter at a second point along its length, the second point being proximal of the first point, the second delivery tube diameter being greater than the first delivery tube diameter, wherein the elongate tube members are flexible;an elongate chamber defined within the delivery tube between the first and second elongate tube member second surfaces, the chamber being configured to accommodate a material therewithin;an elongate catheter extending through the elongate chamber, wherein at the distal end of the delivery tube, the elongate chamber is just large enough to accommodate the elongate catheter, wherein the elongate catheter comprises a stop member extending radially outwardly from a catheter surface, the stop member comprising an annular ring; anda flexible collar disposed on the delivery tube outer surface, the flexible collar engaging both the first and second tube members and being biased to exert an inwardly-directed force urging the tube members toward engagement with one another so as to fit closely about the elongate catheter and to contain the material within the chamber, the collar having a relaxed diameter less than a diameter of at least most of the delivery tube and being slidable over the delivery tube outer surface and configured to expand in diameter as it moves proximally over the delivery tube outer surface from the first point to the second point along the length of the delivery tube; andan elongate pusher member having a distal portion configured to slidably extend through at least a portion of the chamber so as to engage and apply a pushing force to material in the chamber, wherein a coupling member is movably disposed about the elongate catheter and is configured to mechanically couple to a proximal end of the elongate pusher member, wherein the coupling member is threaded on an inner surface and is configured to engage a threaded proximal end of the elongate pusher member, such that when the coupling member and the elongate pusher member are engaged, the stop member is locked between the proximal end of the elongate pusher member and a proximal wall of the coupling member. 12. The apparatus of claim 11, wherein the chamber has a first chamber diameter at a first point along its length and a second chamber diameter at a second point along its length, the second point being proximal of the first point, the second chamber diameter being greater than the first chamber diameter, and wherein a diameter of the distal portion of the elongate pusher member is less than the second chamber diameter but greater than the first chamber diameter. 13. The apparatus of claim 11, wherein the flexible collar is configured as a broken ring. 14. The apparatus of claim 11, wherein the elongate catheter is generally straight and is sized between about 4-8 F. 15. The apparatus of claim 11, wherein the first and second elongate tube members are thin-walled.
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