최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0488469 (2009-06-19) |
등록번호 | US-9364619 (2016-06-14) |
발명자 / 주소 |
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출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 3 인용 특허 : 803 |
Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of th
Described herein are interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The devices can be used in a wired or wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system, to evaluate the performance of the inhalation system and/or to detect the characteristics profile of a dry powder formulation emitted from the inhalation system in use.
1. A dry powder inhalation detection system comprising: a dry powder inhalera unit dose cartridge structurally configured for said dry powder inhaler, anda removable device comprising a sensor in communication with said dry powder inhaler, wherein said sensor detects at least one type of signal gene
1. A dry powder inhalation detection system comprising: a dry powder inhalera unit dose cartridge structurally configured for said dry powder inhaler, anda removable device comprising a sensor in communication with said dry powder inhaler, wherein said sensor detects at least one type of signal generated from said dry powder inhaler and sends said at least one signal to at least one microprocessor external to the dry powder inhaler for analysis, storage, printing or display, and further wherein said sensor is configured to transmit in real-time said signal by wire or wireless communication mode to said at least one microprocessor, and said sensor detects a sound signal,wherein the microprocessor is configured to execute an algorithm to measure and display concurrently the sound signal as an inhalation maneuver occurs. 2. The dry powder inhalation system of claim 1, wherein said sensor is configured within said dry powder inhalation detection system. 3. The dry powder inhalation system of claim 1, wherein the sound signal is an amplitude of the sound signal, a frequency of the sound signal or combinations thereof. 4. The dry powder inhalation system of claim 1, wherein said sensor is a microphone. 5. The dry powder inhalation system of claim 1, wherein said cartridge comprises a dry powder for pulmonary delivery. 6. The dry powder inhalation system of claim 5, wherein the dry powder comprises diketopiperazine microparticles. 7. The dry powder inhalation system of claim 5, wherein the dry powder comprises at least one active ingredient. 8. The dry powder inhalation system of claim 7, wherein said at least one active ingredient comprises insulin, GLP-1, or analogues thereof. 9. The dry powder inhalation system of claim 1, wherein said dry powder inhaler has a resistance value between about 0.065 (√kPa)/liter per minute and about 0.200 (√kPa)/liter per minute. 10. The dry powder inhalation system of claim 1, wherein an analog to digital converter communicates said at least one sound signal to a microprocessor configured to analyze and process said at least one sound signal. 11. The dry powder inhalation system of claim 1, wherein display device is a computer monitor. 12. A monitoring system for a dry powder inhaler comprising: a detachable monitoring device attached to said dry powder inhaler having a unit dose cartridge and comprising a sound sensor configured to transmit in real-time data by wire or wireless communication mode to an external microprocessor including an analog to digital converter and a data storage medium, said data storage medium including a set of machine-readable instructions that are executable by a processing device to implement an algorithm, said algorithm comprising instructions for manipulating said data including the steps of:receiving said data from said sound sensor, filtering said data; transforming said data; analyzing said data;providing a graphical display in real-time of an inhalation maneuver through the dry powder inhaler; andmonitoring a patient in real time using said data. 13. The monitoring system of claim 12, wherein said at least one sensor is a microphone. 14. The monitoring system of claim 12, wherein said detachable monitoring device is mountable on an inhaler. 15. The monitoring system of claim 12, wherein said monitoring device provides a graphical display which is a real-time graphical representation of an inhalation. 16. A method for measuring pressure differential during an inhalation maneuver, comprising: providing a dry powder inhaler to a subject wherein said dry powder inhaler comprises a unit dose cartridge and a removable device comprising a sensor configured to detect at least one amplitude of sound signal, at least one frequency of sound signal or combinations thereof generated from said dry powder inhaler, and further wherein said sensor is configured to transmit in real-time said signals by wire or wireless communication mode,having said subject inhale for at least one second;analyzing said at least one amplitude of sound signal, said at least one frequency of sound signal, or combinations thereof in real time using an algorithm provided with a computer system to generate a data set; anddisplaying in real-time said data set as a graphical representation of time and pressure. 17. An interactive dry powder inhalation system for monitoring an inhalation performed by a user, comprising: a dry powder inhaler comprising a cartridge and having a resistance to flow values between 0.065 (√kPa)/liter per minute and 0.200 (√kPa)/liter per minute;a removable device comprising a transducer configured to detect a signal generated from the inhaler in use, andan external device including a display device configured to display in real-time a graphical representation of an inhalation maneuver performed by a user, wherein said transducer is configured to transmit in real-time said signal to the external device by wire or wireless communication mode. 18. The interactive dry powder inhalation system of claim 17, wherein the transducer senses and measures a pressure differential within the inhaler. 19. The interactive dry powder inhalation system of claim 17, wherein the transducer is a flow meter configured to sense and measure flow rate through air conduits of the dry powder inhaler. 20. The interactive dry powder inhalation system of claim 17, wherein the transducer is a microphone configured to sense and measure a sound signal generated from within the inhaler. 21. The interactive dry powder inhalation system of claim 17, wherein the inhalation maneuver is displayed on a display device as a graph of pressure versus time. 22. The interactive dry powder inhalation system of claim 17, further comprising a microprocessor which communicates with the transducer by wire connections or wireless. 23. A sensing and monitoring device for adapting to a dry powder inhaler, comprising: a detachable device structurally configured to adapt to a dry powder inhaler; said detachable device comprising a microphone for detecting sound generated in said dry powder inhaler and said detachable device is configured to transmit in real-time a signal by wire or wireless communication mode; and wherein the dry powder inhaler has a resistance to flow value between 0.065 (√kPa)/liter per minute and 0.200 (√kPa)/liter per minute,wherein the signal is received by an external device configured to execute an algorithm to measure an inhalation maneuver. 24. The sensing and monitoring device of claim 23, wherein the detachable device communicates signals to an analog to digital converter configured to communicate signals to a microprocessor and/or a display device. 25. A removable sensing and monitoring device for a dry powder inhalation system comprising a dry powder inhaler having a unit dose cartridge and a dry powder formulation, wherein the sensing and monitoring device comprises a microphone configured to detect sound signals generated from the dry powder formulation emitted from the dry powder inhalation system during an inhalation maneuver by a subject, and further wherein said sensing and monitoring device is configured to transmit data signals generated by the sensing and monitoring device in real-time by wire or wireless communication mode to at least one external computing device configured to execute an algorithm to measure and display concurrently the inhalation maneuver.
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