Analyte detection devices and methods with hematocrit/volume correction and feedback control
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-021/78
A61B-005/155
A61B-005/145
A61B-005/00
G01N-033/543
G01N-033/66
A61B-005/157
G01N-021/75
출원번호
US-0614177
(2015-02-04)
등록번호
US-9366636
(2016-06-14)
발명자
/ 주소
Emery, Jeffrey L.
Stivers, Carole R.
출원인 / 주소
Intuity Medical, Inc.
대리인 / 주소
Morrison & Foerster LLP
인용정보
피인용 횟수 :
6인용 특허 :
341
초록▼
Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source
Disclosed are devices, arrangements and methods for quantifying the concentration of an analyte present in bodily fluid, including: an assay pad having at least one chemical reagent capable of producing a detectable signal in the form of a reaction spot upon reaction with the analyte; a light source; a detector array; a processor; and a memory in communication with the processor, the memory comprising: (a) at least one value indicative of one or more of: (i) the level of hematocrit contained in the sample; (ii) the volume of the sample applied to the assay pad; or (iii) imperfections present in the reaction spot; and (b) at least one algorithm for calculating the concentration of the analyte contained in the sample.
대표청구항▼
1. An arrangement for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement comprising: an assay pad comprising at least one chemical reagent capable of producing a detectable signal in the form of a color change at a reaction spot formed upon reaction with t
1. An arrangement for measuring the concentration of an analyte contained in a sample of body fluid, the arrangement comprising: an assay pad comprising at least one chemical reagent capable of producing a detectable signal in the form of a color change at a reaction spot formed upon reaction with the analyte;a light source;a detector array;a processor; anda memory in communication with the processor, the memory comprising: (a) at least one value derived from the color change at the reaction spot indicative of one or more of: (i) the volume of the sample applied to the assay pad; and(ii) imperfections present in the reaction spot; and(b) at least one algorithm for calculating the concentration of the analyte contained in the sample using the at least one value. 2. The arrangement of claim 1, wherein the assay pad comprises only a single chemical reagent. 3. The arrangement of claim 1, wherein the detector array comprises a plurality of pixels, and wherein the at least one value derived from the color change at the reaction spot indicative of the volume of the sample applied to the assay pad is based on the number of pixels in the detector array that have detected the color change. 4. The arrangement of claim 1, wherein the at least one value derived from the color change at the reaction spot indicative of imperfections present in the reaction spot is based on deviations from an expected color or an expected rate of color change. 5. The arrangement of claim 1, wherein the analyte comprises glucose and the body fluid comprises blood. 6. The arrangement of claim 1, wherein the detector array is a linear array. 7. The arrangement of claim 1, wherein the detector array comprises at least one of a linear array, a polar array, and an area array. 8. The arrangement of claim 1, wherein the detector array comprises a plurality of detector elements, the detector elements comprising CMOS, CCD, photodiode, infrared, fluorescent, ultraviolent, or electrochemical elements. 9. The arrangement of claim 1, further comprising at least one body fluid sampling catalyst device. 10. The arrangement of claim 9, wherein the at least one catalyst device comprises at least one of a vacuum pump, a vibration motor, and a heating element. 11. The arrangement of claim 9, wherein the at least one catalyst device is configured to be responsive to control signals, the control signals based on sample volume calculations. 12. The arrangement of claim 8, wherein at least a portion of the plurality of detector elements are not in optical registry with the reagent spot and are configured to analyze one or more of a control solution having a known concentration of analyte introduced onto an area of the assay pad that is different from the area of the reagent spot, a standard color producing a known signal, and calibration information specific to the lot of the assay pad. 13. The arrangement of claim 1, wherein the memory comprises at least one look-up table, and the at least one value is stored in the at least one look-up table. 14. The arrangement of claim 1, wherein the memory comprises a formula for deriving a corrected signal, the formula comprising: Rc=Fx×R where Rc is the corrected signal, Fx is the at least one value indicative of the volume of the sample, and where R is measured reflectance. 15. The arrangement of claim 1, further comprising a needle having a first end configured to pierce the skin, and a second end in fluid communication with the assay pad. 16. An analyte monitoring device comprising the arrangement of claim 1, wherein the arrangement comprises a plurality of assay pads and a plurality of needles, thereby enabling the performance of a plurality of analyte concentration measurements. 17. The analyte monitoring device of claim 16, further comprising a band for attaching the device to the body of the user. 18. An integrated meter comprising: at least one piercing element;at least one actuation member; and the arrangement of claim 1.
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