The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial andii) one hydrophilic polymeric component comprising reactive groupswherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein as
The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial andii) one hydrophilic polymeric component comprising reactive groupswherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, orsaid matrix is impregnated with said polymeric material, orboth.
대표청구항▼
1. A hemostatic porous composite sponge, comprising: a matrix of a biomaterial; anda single hydrophilic polymeric component comprising one or more reactive groups,wherein the matrix and the single hydrophilic polymeric component are associated with each other so that:the reactivity of the single hyd
1. A hemostatic porous composite sponge, comprising: a matrix of a biomaterial; anda single hydrophilic polymeric component comprising one or more reactive groups,wherein the matrix and the single hydrophilic polymeric component are associated with each other so that:the reactivity of the single hydrophilic polymeric component is retained. 2. The hemostatic porous composite sponge claim 1, wherein the biomaterial is selected from the group consisting of collagen, gelatin, fibrin, a polysaccharide, a synthetic biodegradable biomaterial, and derivatives thereof. 3. The hemostatic porous composite sponge of claim 2, wherein the polysaccharide comprises chitosan. 4. The hemostatic porous composite sponge of claim 2, wherein the synthetic biodegradable biomaterial comprises polylactic acid or polyglycolic acid. 5. The hemostatic porous composite sponge of claim 1, wherein the single hydrophilic polymeric component comprises a polyalkylene oxide polymer. 6. The hemostatic porous composite sponge of claim 5, wherein the polyalkylene oxide polymer comprises polyethylene glycol (PEG). 7. The hemostatic porous composite sponge of claim 5, wherein the polyalkylene oxide polymer comprises a multi-electrophilic polyalkylene oxide polymer. 8. The hemostatic porous composite sponge of claim 5, wherein the polyalkylene oxide polymer comprises a multi-electrophilic polyethylene glycol (PEG). 9. The hemostatic porous composite sponge of claim 5, wherein the polyalkylene oxide polymer comprises pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate. 10. The hemostatic porous composite sponge of claim 1, wherein the biomaterial is collagen, wherein the polymeric component is pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate, and wherein the single hydrophilic polymeric component is coated onto the collagen. 11. The hemostatic porous composite sponge of claim 1, wherein the biomaterial is collagen, wherein the polymeric component is pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate, and wherein the single hydrophilic polymeric component is impregnated into the collagen. 12. The hemostatic porous composite sponge claim 1, wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix. 13. The hemostatic porous composite sponge claim 1, wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker. 14. The hemostatic porous composite sponge claim 1, wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker, and wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix. 15. A method of treating an injury, comprising: administering a hemostatic porous composite sponge to the injury, the sponge comprising: a matrix of a biomaterial; anda single hydrophilic polymeric component comprising one or more reactive groups,wherein the matrix and the single hydrophilic polymeric component are associated with each other so that:the reactivity of the single hydrophilic polymeric component is retained andwherein the injury comprises a member selected from the group consisting of a wound, a hemorrhage, a damaged tissue, and a bleeding tissue. 16. The method of claim 15, wherein the sponge is applied to the injury together with a buffer solution. 17. The method of claim 16, wherein the buffer solution comprises a bicarbonate solution. 18. The method of claim 16, wherein the buffer solution is present on a gauze. 19. The method of treating an injury of claim 15, wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix. 20. The method of treating an injury of claim 15, wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker. 21. The method of treating an injury of claim 15, wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker, and wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix. 22. A kit, comprising: a hemostatic porous composite sponge, comprising: a matrix of a biomaterial; anda single hydrophilic polymeric component comprising one or more reactive groups,wherein the matrix and the single hydrophilic polymeric component are associated with each other so that:the reactivity of the single hydrophilic polymeric component is retained,a buffer solution; andinstructions for using the hemostatic porous composite sponge and the buffer solution. 23. The kit of claim 22, wherein the buffer solution comprises an alkaline buffer solution. 24. The kit of claim 23, wherein the alkaline buffer solution comprises a bicarbonate. 25. The kit of claim 22, wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix. 26. The kit of claim 22, wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker. 27. The kit of claim 22, wherein the matrix is impregnated with the single hydrophilic polymeric crosslinker, and wherein the single hydrophilic polymeric crosslinker is coated onto a surface of the matrix.
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