Implantable devices formed on non-fouling methacrylate or acrylate polymers
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-047/00
A61F-013/00
A61L-031/10
A61L-031/04
A61L-031/14
A61L-033/06
출원번호
US-0763113
(2010-04-19)
등록번호
US-9381279
(2016-07-05)
발명자
/ 주소
Pacetti, Stephen D.
출원인 / 주소
Abbott Cardiovascular Systems Inc.
대리인 / 주소
Squire Patton Boggs (US) LLP
인용정보
피인용 횟수 :
0인용 특허 :
114
초록▼
Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissectio
Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
대표청구항▼
1. An stent having a coating comprising a polymer that comprises repeating units of Formula I: wherein:R1 and R2 are independently H, C1-C4 alkyl, silyl groups, siloxy groups, or phenyl,R3, R4, and R5 are independently H, C1-C4 alkyl, silyl groups, siloxy groups, phenyl, poly(ethylene glycol) (PEG),
1. An stent having a coating comprising a polymer that comprises repeating units of Formula I: wherein:R1 and R2 are independently H, C1-C4 alkyl, silyl groups, siloxy groups, or phenyl,R3, R4, and R5 are independently H, C1-C4 alkyl, silyl groups, siloxy groups, phenyl, poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(alkylene oxide),Z is S,X is absence, O, S, or NR7 where R7 is H, CH3, ethyl, propyl, isopropyl, isobutyl, sec-butyl, n-butyl, or phenyl, andn is a positive integer ranging from 1 to 100,000. 2. The stent of claim 1, wherein:X is absent. 3. The stent of claim 1, wherein:X is O. 4. The stent of claim 1, wherein:X is S. 5. The stent of claim 1, wherein:X is NR7. 6. The stent of claim 1, wherein: R3, R4, and R5 are independently H, CH3, ethyl, propyl, isopropyl, isobutyl, sec-butyl, n-butyl, or phenyl, silyl groups, siloxy groups, phenyl, poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(alkylene oxide). 7. The stent of claim 1, wherein: R3, and R4 are independently H and CH3; andR5 is silyl groups, siloxy groups, phenyl, poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(alkylene oxide). 8. The stent of claim 1, further comprising a bioactive agent. 9. The stent of claim 8, wherein the bioactive agent is selected from the group consisting of paclitaxel, docetaxel, estradiol, nitric oxide donors, super oxide dismutases, super oxide dismutases mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and 40-O-tetrazole-rapamycin, ABT-578, clobetasol, prodrugs thereof, co-drugs thereof, and a combination thereof. 10. A method of fabricating a stent, comprising forming on the stent a coating according to claim 1. 11. A method of treating a disorder in a patient comprising implanting in the patient the implantable device of claim 1, wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
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