[특허]Method of manufacturing solid solution perforator patches and uses thereof

Method of manufacturing solid solution perforator patches and uses thereof 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B29C-033/38 A61M-037/00 B29C-033/30 B29C-033/00 A61B-017/20 A61B-017/00
출원번호	US-0994148 (2009-05-21)
등록번호	US-9381680 (2016-07-05)
국제출원번호	PCT/US2009/003145 (2009-05-21)
§371/§102 date	20110204 (20110204)
국제공개번호	WO2009/142741 (2009-11-26)
발명자 / 주소	Oh, Sea-Jin Kwon, Sung-Yun
출원인 / 주소	TheraJect, Inc.
대리인 / 주소	Brinks Gilson & Lione
인용정보	피인용 횟수 : 0 인용 특허 : 92

초록 ▼

Methods for fabricating and manufacturing solid solution perforators (SSPs) using sharp metal or glass needles and/or subsequent molding and use are described. The methods entail making microneedles by various precision machining techniques and micromold structures from curable materials. Various designs of patch, cartridge and applicator are described. Also described are methods for adjusting the microneedle mechanical strength using formulation and/or post-drying processes.

대표청구항 ▼

1. A method of manufacturing a microneedle array, the method comprising: (a) preparing a positive master mold comprising a plurality of microneedles penetrating through a defining plate to extend from a bottom surface thereof, wherein the plurality of microneedles are spaced from one another at a predetermined distance;(b) individually adjusting at least some of the plurality of microneedles by an actuator array individually moving the at least some microneedles through the defining plate to extend different distances from the bottom surface thereof, thereby providing a desired surface contour to the master mold;(c) preparing a negative mold having a negative surface contour that is the reverse of the desired surface contour of the positive master mold by shaping a curable gel or thermoplastic material against the bottom surface of the defining plate having the adjusted microneedles;(d) preparing a microneedle array having a surface contour that is the reverse of the negative surface contour of the negative mold by shaping a dissolvable polymer against the negative mold; and(e) drying the microneedle array. 2. The method of claim 1, wherein the curable gel or thermoplastic material is uncured silicone. 3. The method of claim 1, wherein the curable gel or thermoplastic material is polydimethylsilozane (PDMS). 4. The method of claim 1, wherein the dissolvable polymer is a hydrogel. 5. The method of claim 4, wherein the hydrogel comprises sodium carboxymethyl cellulose (SCMC). 6. The method of claim 1, wherein the dissolvable polymer holds a selected drug. 7. The method of claim 1, further comprising applying a vacuum, centrifugal, or compressive force to the negative mold to fill the negative mold with the dissolvable polymer and/or with a selected drug. 8. The method of claim 1, further comprising separating the dried microneedle array from the negative mold. 9. The method of claim 1, wherein the method further comprises casting an adhesive layer between microneedles of the microneedle array. 10. The method of claim 1, wherein the method further comprises incorporating vitamin C into the dissolvable polymer. 11. The method of claim 1, wherein the method further comprises creating a micro-hole at a location through the negative mold. 12. The method of claim 1, wherein said shaping of the curable gel or thermoplastic material is conducted either by casting or by dipping. 13. A method of manufacturing a microneedle array system, the method comprising: (a) manufacturing a microneedle array according to the method of claim 1; and(b) mounting the microneedle array in a cartridge for delivery to skin. 14. The method of claim 13, wherein the cartridge is in association with an injector.

이 특허에 인용된 특허 (92)

Maganias Nicholas H. (Reston Medical Bldg. ; 1712 Club House Rd. Reston VA 22090), Allergy test strip.
상세보기
Cox Brian J. (10191 Lebanon Dr. Cupertino CA 95014), Anal patch for fecal incontinence.
상세보기
Sherman Faiz Feisal ; Yuzhakov Vadim Vladimirovich ; Gartstein Vladimir ; Owens Grover David, Apparatus and method for manufacturing an intracutaneous microneedle array.
상세보기
Yuzhakov Vadim Vladimirovich ; Sherman Faiz Feisal ; Owens Grover David ; Gartstein Vladimir, Apparatus and method for using an intracutaneous microneedle array.
상세보기
Trautman, Joseph C.; Worsham, Robert Wade; Bayramov, Danir F.; Bowers, Danny Lee; Klemm, Steven Richard; Singh, Parminder, Applicators for microneedles.
상세보기
Leighton Stephen B. (Maplewood NJ) Brownstein Michael J. (Rockville MD), Array-type multiple cell injector.
상세보기
Nelson Charles W., Attachment unit for hair replacement.
상세보기
Dunn Richard L. ; English James P. ; Cowsar Donald R. ; Vanderbilt David P., Biodegradable in-situ forming implants and methods of producing the same.
상세보기
Thomas Buch-Rasmussen DK; S?ren Aasmul DK; James M. Flink DK; Philip Hansen DK; Claus Juul-Mortensen DK; Jens Ulrik Poulsen DK, Cassette for storing and insertion of solid medicine.
상세보기
Jonathan A. Eppstein ; Michael R. Hatch ; Joseph Papp ; Mark L. Faupel ; Krishna Kumar, Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport.
상세보기
Gonzalez-Zugasti, Javier; Boccuti, A. David; Chickering, III, Donald E.; Michelman, Mark; Haghgooie, Ramin; Davis, Shawn; James, Scott; Dadgar, Maisam; Fisher, Greg; Miller, Richard L.; Morse, Christopher J., Delivering and/or receiving fluids.
상세보기
Gonzalez-Zugasti, Javier; Boccuti, A. David; Chickering, III, Donald E.; Michelman, Mark; Haghgooie, Ramin; Davis, Shawn; James, Scott; Dadgar, Maisam; Fisher, Greg; Miller, Richard L.; Morse, Christopher J.; Bernstein, Howard; Levinson, Douglas A., Delivering and/or receiving fluids.
상세보기
Fischer, Dan E., Dental intraligamentary injection needles and related methods of manufacture.
상세보기
Julian A. Blair GB, Derivatized carbohydrates, compositions comprised thereof and methods of use thereof.
상세보기
Cormier Michel J. N. ; Theeuwes Felix T., Device and method for enchancing transdermal sampling.
상세보기
Cormier Michel J. N. ; Nat Avtar S. ; Neukermans Armand P. ; Block Barry, Device for enhancing transdermal agent delivery or sampling.
상세보기
Trautman Joseph Creagan ; Cormier Michel J. N. ; Kim Hyunok Lynn ; Zuck Michael G., Device for enhancing transdermal agent flux.
상세보기
Trautman Joseph Creagan ; Wong Patrick S.-L. ; Daddona Peter E. ; Kim Hyunok Lynn ; Zuck Michael G., Device for enhancing transdermal agent flux.
상세보기
Zuck Michael G., Device for enhancing transdermal agent flux.
상세보기
Down, James; Harvey, Noel G.; Martin, Frank E.; Pettis, Ronald J.; Lastovich, Alexander G., Device for withdrawing or administering a substance and method of manufacturing a device.
상세보기
Prausnitz, Mark R.; Allen, Mark G.; Henry, Sebastien; McAllister, Devin V.; Ackley, Donald E.; Jackson, Thomas, Devices and methods for enhanced microneedle penetration of biological barriers.
상세보기
Bernstein, Howard; Chickering, III, Donald E.; Levinson, Douglas A.; Walt, David R.; Davis, Shawn; Haghgooie, Ramin, Devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications.
상세보기
Roser Bruce Joseph,GBX, Disposable injector device.
상세보기
Gerstel Martin S. (Palo Alto CA) Place Virgil A. (Palo Alto CA), Drug delivery device.
상세보기
Panoz Donald E. (Athlone IEX), Drug delivery device.
상세보기
Sun, Ying; Oakeson, Ralph W.; Wisniewski, Stephen J.; Wang, Jonas C. T.; Niemiec, Susan M., Electrotransort device comprising blades.
상세보기
Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT), Enhancement of transdermal delivery with ultrasound and chemical enhancers.
상세보기
Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT) Kost Joseph (Omer MA ILX) Langer Robert S. (Newton MA), Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers.
상세보기
Lebouitz Kyle S. ; Pisano Albert P., Epidermal abrasion device with isotropically etched tips, and method of fabricating such a device.
상세보기
Chengzeng Xu ; Chengjiu Wu ; Kelly M. T. Stengel ; Lawrence W. Shacklette ; Louay Eldada ; James T. Yardley, High performance acrylate materials for optical interconnects.
상세보기
Lin Liwei (Berkeley CA) Pisano Albert P. (Berkeley CA), IC-processed microneedles.
상세보기
Lin Liwei ; Pisano Albert P., IC-processed microneedles.
상세보기
John Willis ; Thaddeus Minior ; Robert Gonnelli, Injection devices.
상세보기
de Montebello Roger L. (New York NY) Globus Ronald P. (New York NY) Buck Howard S. (New York NY), Integral photography apparatus and method of forming same.
상세보기
Lüttge, Regina; Bystrova, Svetlana Nikolajevna; van Bennekom, Joost Gerardus; Domanski, Maciej; Loeters, Patrick Wilhelmus Hendrikus; Lammertink, Rob Gerhardus Hendrikus; Winnubst, Aloysius Johannes Antonius, Integrated microneedle array and a method for manufacturing thereof.
상세보기
Vladimir Gartstein ; Dragan Danilo Nebrigic ; Grover David Owens ; Faiz Feisal Sherman ; Vadim Vladimirovich Yuzhakov, Intracutaneous microneedle array apparatus.
상세보기
Gross Joseph (Rathgar IEX) Kelly John G. (Rathgar IEX), Intradermal drug delivery device and method for intradermal delivery of drugs.
상세보기
Gross Joseph,IEX ; Kelly John Gerard,IEX, Intradermal drug delivery device and method for intradermal delivery of drugs.
상세보기
Schott, Kevin, Low-pressure packaging for fluid devices.
상세보기
Haaga John R. (3409 N. Hilltop Chagrin Falls OH 44022), Medical needle with bioabsorbable tip.
상세보기
Wilk Peter J. ; Knoll Charles L. ; Wexler Eugene, Medical treatment and waste disposal method.
상세보기
Godshall Ned Allen ; Anderson R. Rox, Method and apparatus for disruption of the epidermis.
상세보기
Eckhouse, Shimon; Kutscher, Tuvia Dror; Bar-Ilan, Gilead, Method and apparatus for personal skin treatment.
상세보기
Gertsek, Marina; Wilkinson, Bradley M.; Pettis, Ronald J., Method and delivery device for the transdermal administration of a substance.
상세보기
Kreindel, Michael, Method and system for invasive skin treatment.
상세보기
Kreindel, Michael, Method and system for invasive skin treatment.
상세보기
Prausnitz, Mark R.; Jiang, Ninghao; Edelhauser, Henry F., Method for drug delivery to ocular tissue using microneedle.
상세보기
Jarvis Eric E. (Boulder CO), Method for fabricating a substrate having spaced apart microcapillaries thereon.
상세보기
Talbot Neil H. ; Keller Christopher G. ; Pisano Albert P., Method for fabricating needles via conformal deposition in two-piece molds.
상세보기
Drew J. Buoni ; Alan R. Kaufman, Method for forming multi-layer laminates with microstructures.
상세보기
Lastovich, Alexander G., Method of forming a mold and molding a micro-device.
상세보기
Arias, Francisco; Sherman, Faiz Feisal; Owens, Grover David, Method of manufacturing microneedle structures using soft lithography and photolithography.
상세보기
Ferguson, Dennis E.; Nayar, Satinder K.; Pochardt, Donald L., Method of molding a microneedle.
상세보기
Prausnitz, Mark R.; Edelhauser, Henry F.; Patel, Samirkumar Rajnikant, Methods and devices for drug delivery to ocular tissue using microneedle.
상세보기
Prausnitz, Mark R.; Edelhauser, Henry F.; Patel, Samirkumar Rajnikant, Methods and devices for drug delivery to ocular tissue using microneedle.
상세보기
Prausnitz, Mark R.; Edelhauser, Henry F.; Patel, Samirkumar Rajnikant, Methods and devices for drug delivery to ocular tissue using microneedle.
상세보기
Alexander G. Lastovich ; John D. Evans ; Ronald J. Pettis, Microdevice and method of manufacturing a microdevice.
상세보기
DeVoe, Robert J.; Leatherdale, Catherine A.; Mao, Guoping; Fleming, Patrick R.; Kalweit, Harvey W., Microfabrication of organic optical elements.
상세보기
Delmore, Michael D.; Fleming, Patrick R.; Huntley, Douglas A.; Keister, Jamieson C.; Thomas, Cristina U.; Ferber, Richard H., Microneedle arrays and methods of manufacturing the same.
상세보기
Mark G. Allen ; Mark R. Prausnitz ; Devin V. McAllister ; Florent Paul Marcel Cros, Microneedle devices and methods of manufacture and use thereof.
상세보기
Prausnitz, Mark R.; Allen, Mark G.; Gujral, Inder-Jeet, Microneedle drug delivery device.
상세보기
Pisano Albert P. ; Lebouitz Kyle S., Microneedle with isotropically etched tip, and method of fabricating such a device.
상세보기
Eppstein Jonathan A. ; Hatch Michael R. ; Yang Difei, Microporation of human skin for drug delivery and monitoring applications.
상세보기
Daddona Peter E. ; Fieldson Gregory T. ; Nat Avtar S. ; Lin Wei-Qi, Minimally invasive detecting device.
상세보기
Yeung, King Lun; Wong, Ling Wai; Sun, Wenqing; Leung, Wai Kin; Lai, Wing Yan; Chan, Ngar Wai, Molecular sieve and zeolite microneedles and preparation thereof.
상세보기
Levinson, Douglas A.; Bernstein, Howard; Chickering, III, Donald E., Monitoring or feedback systems and methods.
상세보기
Chacornac ; Georges, Multi-penetration vaccination apparatus.
상세보기
Lee, Kwangyeol, Nano pattern writer.
상세보기
Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
상세보기
Sarath Alan (Teaneck NJ) Mawhirt James A. (Brooklyn NY), Needle cartridge.
상세보기
Bellhouse Brian John,GBX ; Drayson Paul Rudd,GBX ; Greenford John Christopher,GBX ; Sarphie David Francis,GBX, Particle delivery.
상세보기
Chen, Xianfeng; Kendall, Mark Anthony Fernance; Prow, Tarl; Raphael, Anthony Paul, Patch production.
상세보기
Kendall, Mark Anthony Fernance; Jenkins, Derek William Kenneth, Patch production.
상세보기
Haghgooie, Ramin; Chickering, III, Donald E.; Davis, Shawn; Michelman, Mark; Bernstein, Howard; Horton, Kristin, Plasma or serum production and removal of fluids under reduced pressure.
상세보기
Yeshurun, Yehoshua; Hefetz, Meir; Berenschot, Erwin; de Boer, Meint; Altpeter, Dominique Maria; Boom, Garrit, Polymer microneedles.
상세보기
DeVoe, Robert J.; Ferguson, Dennis E.; Frederickson, Franklyn L.; Johnson, Mitchell A. F.; Pekurovsky, Mikhail L.; Sykora, Craig R.; Larsen, Jeremy K., Process for making microneedles, microneedle arrays, masters, and replication tools.
상세보기
Powell Kenneth G. ; Monahan Larry A. ; Sage ; Jr. Burton H., Process of making a molded device.
상세보기
Chickering, III, Donald E.; Bernstein, Howard; Davis, Shawn; Haghgooie, Ramin; Levinson, Douglas A.; Michelman, Mark; Gong, Ping, Sampling devices and methods involving relatively little pain.
상세보기
Lawson Alexis A. ; Lawson Michael, Skin penetration apparatus including multiple needle configuration.
상세보기
Jang Kwang Kyun,KRX, Skin perforating apparatus for transdermal medication.
상세보기
Flyash, Lion; Vaynberg, Boris, Skin treatment apparatus for personal use and method for using same.
상세보기
Roser Bruce J.,GBX ; Kampinga Jaap,NLX ; Colaco Camilo,GBX ; Blair Julian,GBX, Solid dose delivery vehicle and methods of making same.
상세보기
Kwon, Sung-Yun, Solid micro-perforators and methods of use.
상세보기
Kwon, Sung-Yun, Solid solution perforator for drug delivery and other applications.
상세보기
Kwon,Sung Yun, Solid solution perforator for drug delivery and other applications.
상세보기
Singh, Parminder; Worsham, Robert Wade; Trautman, Joseph C.; Bayramov, Danir; Bowers, Danny Lee; Klemm, Andy; Klemm, Steven Richard; Chen, Guohua, Solvent-cast microprotrusion arrays containing active ingredient.
상세보기
Kamen Dean L., System for delivery of drugs by transport.
상세보기
Brancazio, David, Systems and interfaces for blood sampling.
상세보기
Eicher Joachim,DEX ; Zierenberg Bernd,DEX, Transcorneal drug-release system.
상세보기
Lee Hai Bang (Taejeon KRX) Shin Bung Chul (Taejeon KRX), Transdermal administration method of protein or peptide drug and its administration device thereof.
상세보기
Gross Joseph (Moshav Mazor ILX) Zucker Shlomo (Mihmoret ILX), Transdermal or interdermal drug delivery devices.
상세보기
Ghartey-Tagoe, Esi; Wendorf, Janet; Williams, Steve; Singh, Parminder; Worsham, Robert Wade; Trautman, Joseph C.; Bayramov, Danir; Bowers, Danny Lee; Klemm, Andy; Klemm, Steven Richard; Chen, Guohua, Vaccine delivery via microneedle arrays.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Method of manufacturing solid solution perforator patches and uses thereof 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허에 인용된 특허 (92)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Method of manufacturing solid solution perforator patches and uses thereof 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (92)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트