Fixed volume aseptic sampling valve for sampling from enclosed containers
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-001/10
C12M-001/26
출원번호
US-0072228
(2013-11-05)
등록번호
US-9389151
(2016-07-12)
발명자
/ 주소
Newbold, David Dixon
Millard, Douglas Lee
Yu, Erwin Yaokui
Jeffers, Paul T.
Weber, Jeffrey W.
출원인 / 주소
Bend Research, Inc.
대리인 / 주소
Klarquist Sparkman, LLP
인용정보
피인용 횟수 :
0인용 특허 :
20
초록
A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
대표청구항▼
1. A sampling system for collecting a fluid sample from an enclosed container, the system comprising: (a) a sanitizing fluid inlet valve;(b) a gas inlet valve;(c) a sample collection valve having a valve stem, the sample collection valve being operable between an open position and a closed position;
1. A sampling system for collecting a fluid sample from an enclosed container, the system comprising: (a) a sanitizing fluid inlet valve;(b) a gas inlet valve;(c) a sample collection valve having a valve stem, the sample collection valve being operable between an open position and a closed position;(d) a first outlet valve operable between an open position and a closed position;(e) a fixed volume reservoir; and(f) a second outlet valve operable between an open position and a closed position;(g) a fluid flow path interconnecting (a)-(f),wherein when (a) and (b) are oriented to restrict flow of the sanitizing fluid and gas through the respective valves, (f) is in the closed position, and (d) is in the open position, (c) can be in the open position to withdraw a sample from the enclosed container into the reservoir along a first portion of the fluid flow path,wherein when (a) and (c) are oriented to restrict flow of the sanitizing fluid and sample through the respective valves, (f) is in the closed position, and (b) is in the open position, the sample can be discharged from the reservoir along a second portion of the fluid flow path through (d), andwherein when (a) is oriented to permit flow of the sanitizing fluid through the sanitizing fluid inlet valve, (b) is oriented to restrict flow of the gas through the gas inlet valve, and (c) is in the closed position, a sanitizing fluid can be introduced into the fluid flow path through (a) to sanitize at least the first portion of the fluid flow path and a portion of the valve stem that extends into a fluid flow path when (c) is in the closed position,wherein (b) is at an upstream portion of the fluid flow path relative to (c), and when (b) is in an open position and (c) is in a closed position, a gas can flow through (b) into the first portion of the fluid flow path and past the valve stem. 2. The sampling system of claim 1, wherein when (a) is in the open position and (b) and (c) are in the closed position, the sanitizing fluid also sanitizes the reservoir. 3. The sampling system of claim 1, wherein (a) is at an upstream portion of the fluid flow path and (d) is at a downstream portion of the fluid flow path, and the sanitizing fluid can flow through the fluid flow path from (a) to (f) to sanitize the fluid flow path between (a) and (f). 4. The sampling system of claim 3, wherein (a)-(f) are interconnected along the fluid flow path from the upstream portion to the downstream portion in the following order: (a), (b), (c), (e), (d), and (f). 5. The sampling system of claim 1, wherein the sanitizing fluid inlet valve is operable between an open position and a closed position, the gas inlet valve is operable between an open position and a closed position, and the sanitizing fluid inlet valve and gas inlet valve are separate valves. 6. The sampling system of claim 1, wherein the sanitizing fluid inlet valve and the gas inlet valve are coupled via a three-way valve, the three way valve being operable between a first position that permits the flow of sanitizing fluid through the sanitizing fluid inlet into the fluid flow path, a second position that permits the flow of gas through the gas inlet into the fluid flow path, and a third position that restricts the flow of both sanitizing fluid and gas into the fluid flow path. 7. The sampling system of claim 1, the second outlet valve (f) being located downstream of the first outlet valve (d), wherein when (a) is oriented to permit flow of the sanitizing fluid through the sanitizing fluid inlet valve, (b) is oriented to restrict flow of the gas through the gas inlet valve, and (c) and (d) are in the closed position, the sanitizing fluid can flow along the fluid flow path between (a) and the second outlet valve (f) to sanitize portions of the fluid flow path in the vicinity of (c) and (d). 8. The sampling system of claim 7, wherein the second outlet valve (f) comprises a variable back-pressure regulator. 9. The sampling system of claim 7, wherein when (a) is oriented to restrict flow of the sanitizing fluid through the sanitizing fluid inlet valve and (c) is in the closed position, (b) is oriented to permit flow of the gas through the gas inlet valve, (d) is in the closed position, and (f) is in the open position, gas can be introduced into the fluid flow path through (b) to purge the sanitizing fluid from at least the first and second portions of the fluid flow path. 10. The sampling system of claim 1, wherein the valve stem has a tapered sealing member. 11. A method of collecting a fluid sample from an enclosed container, the method comprising: opening a sanitizing fluid inlet valve and directing sanitizing fluid downstream through a fluid flow path past a closed sample collection valve and a closed first outlet valve, the sanitizing fluid contacting the closed sample collection valve to sanitize the sample collection valve;discharging the sanitizing fluid out a second outlet valve, the second outlet valve being located downstream of the first outlet valve;opening a sample collection valve while the sanitizing fluid inlet valve and first outlet valve are closed;drawing a fluid sample from the enclosed container into a fixed volume reservoir along a first portion of the fluid flow path;directing the fluid sample out of the reservoir along a second portion of the fluid flow path;discharging the fluid sample out of the first outlet valve while the sanitizing fluid inlet valve and sample collection valve are closed, andafter discharging the sanitizing fluid but before drawing the fluid sample, opening a gas inlet valve and directing a gas downstream through the fluid flow path past the closed sample collection valve and through the first open outlet valve, and discharging the gas through the second outlet valve to purge the sanitizing fluid from at least the first and second portions of the fluid flow path. 12. The method of claim 11, wherein the reservoir comprises a pump that is configured to draw the sample into the reservoir through a reservoir inlet and direct the sample out of the reservoir through a reservoir outlet. 13. The method of claim 11, wherein the sanitizing fluid comprises steam. 14. A sampling system for collecting a fluid sample from an enclosed container, the system comprising: (a) a sample collection valve operable between an open position and a closed position;(b) a first outlet valve operable between a waste delivery position and a non-waste delivery position;(c) a fixed volume reservoir;(d) a fluid flow path interconnecting the sample collection valve, first outlet valve, and the fixed volume reservoir;(e) a sanitizing fluid inlet into the fluid flow path; and(f) a gas inlet into the fluid flow path;wherein the fixed volume reservoir can withdraw a sample from the enclosed container along the fluid flow path and into the fixed volume reservoir when the sample collection valve is in the open position and the first outlet valve is in the non-waste delivery position, and the fixed volume reservoir can discharge the sample from the fixed volume reservoir and out of the fluid flow path of the sampling system for subsequent analysis when the sample collection valve is in the closed position,wherein, after discharge of the sample for subsequent analysis and with the first outlet valve in the non-waste delivery position, a sanitizing fluid can be introduced into the fluid flow path via the sanitizing fluid inlet to sanitize the sample collection valve when it is in the closed position, andwherein, after sanitizing the apparatus, the first outlet valve can be moved to the waste delivery position and a gas can be introduced into the fluid flow path, directed across at least a portion of the sample collection valve when it is in the closed position, and discharged out the first outlet valve. 15. The sampling system of claim 14, wherein the sanitizing fluid inlet is at an upstream portion of the fluid flow path and the first outlet valve is at a downstream portion of the fluid flow path, and the sanitizing fluid can flow through the fluid flow path from between the sanitizing fluid inlet to the first outlet valve to sanitize the fluid flow path therebetween. 16. The sampling system of claim 14, wherein the sanitizing fluid inlet and the gas inlet are coupled via a three-way valve, the three way valve being operable between a first position that permits the flow of sanitizing fluid through the sanitizing fluid inlet into the fluid flow path, a second position that permits the flow of gas through the gas inlet into the fluid flow path, and a third position that restricts the flow of both sanitizing fluid and gas into the fluid flow path. 17. The sampling system of claim 14, wherein the non-waste delivery position of the first outlet valve comprises a first orientation wherein the sample in the fluid flow path can pass through the first outlet valve for subsequent analysis and a second orientation wherein no fluid can pass through the first outlet valve. 18. The sampling system of claim 14, wherein the fixed volume reservoir is downstream of the sample collection valve. 19. The sampling system of claim 14, wherein the fixed volume reservoir is upstream of the sample collection valve. 20. The sampling system of claim 14, wherein the sanitizing fluid inlet and gas inlet are both positioned upstream of the sample collection valve.
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이 특허에 인용된 특허 (20)
Hoiss Jakob (Waldhornstrasse 31 D-8000 Mnchen 50 DEX), Apparatus for aseptically discharging flowable substances.
Newberg Douglas A. (Annapolis MD) Pavlin Vjekoslav (Adelphi MD) Newberg Richard R. (Royal Oak MD) Yang Jackson C. S. (Silver Spring MD), Automated sample extractor or feeder/inoculator for bioreactors and similar equipment.
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