Controlling charge flow in the electrical stimulation of tissue
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/08
A61N-001/36
A61N-001/372
출원번호
US-0836440
(2010-07-14)
등록번호
US-9393421
(2016-07-19)
발명자
/ 주소
Carbunaru, Rafael
McClure, Kelly H.
Parramon, Jordi
출원인 / 주소
Boston Scientific Neuromodulation Corporation
대리인 / 주소
Lewis, Reese & Nesmith, PLLC
인용정보
피인용 횟수 :
8인용 특허 :
86
초록▼
Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering th
Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.
대표청구항▼
1. A system, comprising: memory configured to store a charge setting value that quantifies, in terms of electrical charge, an amount of electrical charge that is to flow during a stimulation pulse; anda waveform generator configured to generate and deliver the stimulation pulse in a manner such that
1. A system, comprising: memory configured to store a charge setting value that quantifies, in terms of electrical charge, an amount of electrical charge that is to flow during a stimulation pulse; anda waveform generator configured to generate and deliver the stimulation pulse in a manner such that an amount of charge delivered to tissue during the stimulation pulse is equal to the stored charge setting value. 2. The system of claim 1, wherein each of the stored charge setting value and the amount of charge delivered to the tissue is an absolute value. 3. The system of claim 1, wherein each of the stored charge setting value and the amount of charge delivered to the tissue is an incremental or decremental value. 4. The system of claim 1, wherein the waveform generator is configured to generate a stimulation waveform that includes the stimulation pulse and a secondary pulse, the secondary pulse to reduce accumulation of charge at an electrode that has delivered the stimulation pulse. 5. The system of claim 1, further comprising an extracorporeal user interface configured to receive the charge setting value from a user. 6. The system of claim 2, further comprising an implantable stimulator containing the memory and the waveform generator. 7. The system of claim 1, wherein the waveform generator has a trigger input for receiving a trigger, the waveform generator configured to terminate the generation of the stimulation pulse upon receipt of the trigger, the system further comprising a coulomb counter configured to measure an amount of charge delivered in the stimulation pulse and to generate the trigger when the value of charge delivered to the tissue is substantially equal to the stored charge setting value, the coulomb counter having a trigger output for conveying the trigger to the trigger input of the waveform generator. 8. The system of claim 1, further comprising a converter configured to convert the stored charge setting value into one or more stimulation parameters characterizing aspects of the stimulation pulse that is to be delivered to the tissue, wherein the waveform generator is configured to generate the stimulation pulse in accordance with the stimulation parameters. 9. The system of claim 8, wherein the converter is configured to calculate a duration of the stimulation pulse based on a pulse amplitude of the stimulation pulse. 10. The system of claim 8, further comprising a data compilation storing predetermined charge setting values and corresponding predetermined stimulation pulse durations and amplitudes, wherein the converter is configured to access the data compilation to convert the stored charge setting value into the one or more stimulation parameters. 11. The system of claim 8, wherein the converter is configured to convert the stored charge setting value by holding one of a stimulation pulse amplitude and a stimulation pulse duration substantially constant for two or more different charge settings, and determining the other of the stimulation pulse amplitude and the stimulation pulse duration based on the stored charge setting value and the substantially constant one of the stimulation pulse amplitude and the stimulation pulse duration. 12. A system, comprising: an extracorporeal user interface configured to receive a charge setting value that quantifies, in terms of electrical charge, an amount of electrical charge that is to flow during a stimulation pulse; andan implantable stimulator configured to generate and deliver the stimulation pulse in a manner such that an amount of charge delivered to tissue during the stimulation pulse is equal to the charge setting value. 13. The system of claim 12, wherein each of the charge setting value and the amount of charge delivered to the tissue is an absolute value. 14. The system of claim 12, wherein each of the charge setting value and the amount of charge delivered to the tissue is an incremental or decremental value. 15. The system of claim 12, wherein the implantable stimulator is configured to generate a stimulation waveform that includes the stimulation pulse and a secondary pulse, the secondary pulse to reduce accumulation of charge at an electrode that has delivered the stimulation pulse. 16. The system of claim 12, wherein the implantable stimulator is configured to measure an amount of charge delivered in the stimulation pulse, and to terminate the generation of the stimulation pulse when the value of charge delivered to the tissue is equal to the charge setting value. 17. The system of claim 12, wherein one of the extracorporeal user interface and the implantable stimulator is configured to convert the charge setting value into one or more stimulation parameters characterizing aspects of the stimulation pulse that is to be delivered to the tissue, wherein the implantable stimulator is configured to generate the stimulation pulse in accordance with the stimulation parameters. 18. The system of claim 17, wherein the one of the extracorporeal user interface and the implantable stimulator is configured to calculate a duration of the stimulation pulse based on a pulse amplitude of the stimulation pulse. 19. The system of claim 17, wherein the one of the extracorporeal user interface and the implantable stimulator is configured to store predetermined charge setting values and corresponding predetermined stimulation pulse durations and amplitudes, and to access the data compilation to convert the charge setting values into the one or more stimulation parameters. 20. The system of claim 17, wherein the one of the extracorporeal user interface and the implantable stimulator is configured to convert the charge setting value by holding one of a stimulation pulse amplitude and a stimulation pulse duration substantially constant for two or more different charge settings, and determining the other of the stimulation pulse amplitude and the stimulation pulse duration based on the charge setting value and the substantially constant one of the stimulation pulse amplitude and the stimulation pulse duration.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (86)
Duggan Stephen R. (Rosemount MN), Acoustic signalling apparatus for implantable devices.
Crish Timothy J. (North Olmsted OH) Sweeney James D. (Cleveland Heights OH) Mortimer J. Thomas (Cleveland Heights OH), Antidromic pulse generating wave form for collision blocking.
Boveja Birinder Bob, Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator.
Boveja, Birinder R., Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system.
Ungar Ira J. (Shaker Heights OH) Mortimer J. Thomas (Cleveland Heights OH), Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking.
Whitehurst, Todd K.; McGivern, James P.; Carbunaru, Rafael; Haller, Matthew I.; He, Tom Xiaohai; Bradley, Kerry, Cavernous nerve stimulation via unidirectional propagation of action potentials.
Zacouto Fred (16 rue de la Convention 75 015 Paris FRX), Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemo.
Whitehurst,Todd K; McGivern,James P; Mann,Carla M, Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction.
Schulman Joseph H. (Santa Clarita CA) Strojnik Primoz (Granada Hills CA) Meadows Paul (Altadena CA), Implantable microdevice with self-attaching electrodes.
Corbett ; III Scott S. (Portland OR) Martyniuk Jerry (Portland OR) Loeb Gerald E. (Kingston GA CAX) Mewes Klaus (Lilburn GA) Skiens W. Eugene (Wilsonville OR) Stobie John J. (Portland OR) Beck Doris , Implantable microelectrode.
Schulman Joseph H. (Santa Clarita CA) Loeb Gerald E. (Kingston CA CAX) Gord John C. (Venice CA) Strojnik Primoz (Granada Hills CA), Implantable microstimulator.
Schulman Joseph H. (Santa Clarita CA) Loeb Gerald E. (Kingston CAX) Gord John C. (Venice CA) Strojnik Primoz (Granada Hills CA), Implantable microstimulator.
Loeb Gerald E. (90 Bagot Street Kingston ; Ontario CAX K7L 3E5 ) Schulman Joseph H. (10650 Comet Way Santa Clarita CA 91351), Implantable multichannel stimulator.
Meadows, Paul M.; Mann, Carla M.; Tsukamoto, Hisashi; Chen, Joey, Implantable pulse generators using rechargeable zero-volt technology lithium-ion batteries.
Hahn Stephen J. (Roseville MN) Swanson David K. (Mountain View CA), Method and apparatus for defibrillation using a multiphasic truncated exponential waveform.
Petrofsky Jerrold S. (Beavercreek OH) Glaser Roger M. (Dayton OH) Petrofsky Steven H. (Florissant MO) Heaton ; III Harry H. (Beavercreek OH), Method and apparatus for exercising.
Naritoku Dean K. ; Jensen Robert A. ; Browning Ronald A. ; Clark Kevin B. ; Smith Douglas C. ; Terry ; Jr. Reese S., Methods of treating traumatic brain injury by vagus nerve stimulation.
Faltys Michael A. ; Loeb Gerald E. ; Palmer Logan P. ; Voelkel Andrew W., Multichannel cochlear prosthesis with flexible control of stimulus waveforms.
King-Smith Eric A. (St. Louis Park MN) ReMine Walter J. (St. Paul MN) Dufresne Joel R. (Vadnais Heights MN), Output limited electrical stimulator for biological tissue.
Schulman Joseph H. (Santa Clarita CA) Loeb Gerald E. (Kingston CAX) Gord John C. (Venice) Strojnik Primoz (Sylmar CA), Structure and method of manufacture of an implantable microstimulator.
Taylor Vern (Broomfield CA) Koturov Daniel (both of CO) Bradin John (both of CO) Loeb Gerald E. (Clarksburg MD), Syringe-implantable identification transponder.
Pless, Benjamin D.; Fischell, Robert E.; Fischell, David R., System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes.
Dorfmeister Josef ; Frei Mark ; Lerner David ; Osorio Ivan ; Ralston John, System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain o.
Terry ; Jr. Reese S. (Houston TX) Wernicke Joachim F. (League City TX) Baker ; Jr. Ross G. (Houston TX), Therapeutic treatment of migraine symptoms by stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Zabara Jacob (Philadelphia PA), Treatment of neuropsychiatric disorders by nerve stimulation.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.