Methods and systems for detecting and treating heart instability
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/04
A61N-001/365
A61B-005/0402
A61B-005/00
A61N-001/362
A61B-005/0452
A61B-005/0245
A61B-018/14
A61N-001/36
출원번호
US-0135472
(2013-12-19)
등록번호
US-9393425
(2016-07-19)
발명자
/ 주소
Narayan, Sanjiv
출원인 / 주소
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
대리인 / 주소
Musick, Eleanor
인용정보
피인용 횟수 :
10인용 특허 :
81
초록▼
Systems and methods define an index of risk for cardiac disease by detecting cellular derangements that may lead to cardiomyopathy, heart rhythm disorders or ischemic heart disease. The markers include fluctuations or abnormal rate-behavior of electrical, mechanical or other measurable biosignals. T
Systems and methods define an index of risk for cardiac disease by detecting cellular derangements that may lead to cardiomyopathy, heart rhythm disorders or ischemic heart disease. The markers include fluctuations or abnormal rate-behavior of electrical, mechanical or other measurable biosignals. The invention operates in modes that can be applied to prevent atrial fibrillation or the risk for ventricular arrhythmias. Alternative embodiments are applied to tissue outside the heart such as skeletal muscle, smooth muscle, the central nervous system, the respiratory system, the urogenital system and the gastrointestinal system.
대표청구항▼
1. An apparatus associated with diagnosis and treatment of a suspected heart rhythm disorder in a beating human heart, the apparatus comprising: one or more sensors configured to detect one or more signals from the beating human heart over a plurality of time segments;a diagnostic unit configured to
1. An apparatus associated with diagnosis and treatment of a suspected heart rhythm disorder in a beating human heart, the apparatus comprising: one or more sensors configured to detect one or more signals from the beating human heart over a plurality of time segments;a diagnostic unit configured to calculate one or a combination of signal changes in response to a variation in at least one of rate and regularity induced in the beating human heart, the variation being induced to determine whether the signal changes indicate the suspected heart rhythm disorder, the signal changes being in at least one of signal shape, duration of signal components, signal amplitude and signal characteristics among a first time segment and a second time segment of the plurality of time segments, wherein at least a portion of the second time segment differs from at least a portion of the first time segment; anda therapy unit configured to modify at least one of tissue structure and function based at least in part on the signal changes determined by the diagnostic unit. 2. The apparatus of claim 1, wherein the signals represent action potentials. 3. The apparatus of claim 2, wherein the signal changes in the signal characteristics comprise a change in a slope of a rate-response associated with the signal changes calculated in response to the variation in at least one of rate and regularity induced in the beating human heart. 4. The apparatus of claim 2, further comprising a detection unit to detect conduction slowing. 5. The apparatus of claim 4, wherein the conduction slowing affects at least one of the signal changes calculated in response to the variation in at least one of rate and regularity induced in the beating human heart. 6. An apparatus to assess a risk associated with a suspected heart rhythm disorder comprising: at least one sensor; andan analytic engine comprising: a module configured to measure a signal received via the at least one sensor from a beating human heart;a module configured to calculate a change in the signal among at least a first time segment and a second time segment, the change in the signal being in response to a variation in at least one of rate and regularity induced in the beating human heart, the variation being induced to determine whether the change in the signal indicates the suspected heart rhythm disorder, wherein at least a portion of the second time segment differs from at least a portion of the first time segment; anda module configured to generate a risk score for the suspected heart rhythm disorder determined based at least in part on the change in the signal. 7. The apparatus of claim 6, further comprising a module configured to construct a rate-response curve and measure a slope of the rate-response curve. 8. The apparatus of claim 7, wherein fluctuations in the rate-response curve are affected by signal changes in at least one of shape of the signal, duration of components of the signal, amplitude of the signal and signal characteristics in response to the variation in at least one of rate and regularity induced in the beating human heart. 9. The apparatus of claim 6, further comprising a module configured to control excitation of tissue of the beating human heart. 10. The apparatus of claim 9, wherein excitation of tissue comprises pacing the tissue to change the rate associated with the signal. 11. The apparatus of claim 6, wherein the change in the signal is calculated between alternate beats of the beating human heart. 12. The apparatus of claim 9, wherein excitation of tissue comprises pacing the tissue out-of-phase with changes calculated in the signal at different rates. 13. The apparatus of claim 6, further comprising a module configured to control modification of tissue of the beating human heart. 14. The apparatus of claim 13, wherein modification of tissue comprises ablation of the tissue. 15. The apparatus of claim 6, further comprising: an energy generator coupled to an ablation electrode;an electrode controller coupled to the at least one sensor;a process controller coupled to the electrode controller and the energy generator;a sampling module configured to record the signal; anda pacing module configured to send a pacing signal to a pacing electrode, wherein the signal excites tissue. 16. An apparatus associated with treatment of a suspected heart rhythm disorder in a beating human heart, the apparatus comprising: one or more sensors configured to detect one or more signals from the beating human heart over a plurality of time periods;a diagnostic unit configured to calculate one or a combination of signal changes in response to a variation in at least one of rate and regularity induced in the beating human heart, the variation being induced to determine whether the signal changes the suspected heart rhythm disorder, the signal changes being in at least one of signal shape, duration of signal components, signal amplitude and signal characteristics among a first time period and a second time period of the plurality of time periods, wherein at least a portion of the first time period differs from at least a portion of the second time period; andan assignment unit configured to assign a risk score for the suspected heart rhythm disorder based at least in part on the signal changes calculated by the diagnostic unit. 17. The apparatus of claim 16, wherein the signals represent action potentials. 18. The apparatus of claim 16, wherein the signal changes in the signal characteristics comprise a change in a slope of a rate-response associated with the signal changes calculated in response to the variation in at least one of rate and regularity induced in the beating human heart. 19. The apparatus of claim 16, further comprising a detection unit to detect conduction slowing. 20. The apparatus of claim 19, wherein the conduction slowing affects at least one of the signal changes calculated in response to the variation in at least one of rate and regularity induced in the beating human heart. 21. The apparatus of claim 16, further comprising a modification unit configured to modify at least one of tissue structure and function of the beating human heart based at least in part on the signal changes calculated in response to the variation in at least one of rate and regularity induced in the beating human heart.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (81)
Desai Jawahar M. (4141 Cowell Blvd. ; No. 38 Davis CA 95616), Apparatus and method for cardiac ablation.
White Harley (Redmond WA) Bocek Joseph M. (Seattle WA), Automatic gain control and method for enabling detection of low and high amplitude depolarization activation waves of th.
Branham Barry H. (Ballwin MO) Cox James L. (Ladue MO) Boineau John P. (Ladue MO) Schuessler Richard B. (Ballwin MO), Computerized three-dimensional cardiac mapping with interactive visual displays.
Hauck,John A.; Schweitzer,Jeff A.; Craven,Michael; Afonso,Valtino; Cotner,Holly; Callaghan,Frank; Schultz,John, Method and apparatus for catheter navigation and location and mapping in the heart.
Ghanem, Raja N.; Stadler, Robert W.; Zhang, Xusheng; Kleckner, Karen J.; Krause, Paul G., Method and apparatus for detecting arrhythmias in a medical device.
Stadler Robert ; Nelson Shannon ; Stylos Lee ; Sheldon Todd J., Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals.
Gunderson, Bruce D.; Patel, Amisha S.; Bounds, Chad A.; Brown, Mark L., Method and apparatus for identifying oversensing using far-field intracardiac electrograms and marker channels.
Bj?rling, Anders; Hedberg, Sven-Erik; Lindegren, Ulf; Lindgren, Anders, Method and circuit for detecting cardiac rhythm abnormalities by analyzing time differences between unipolar signals from a lead with a multi-electrode tip.
Efimov, Igor R.; Krinski, Valentin I.; Nikolski, Vladimir P., Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries.
Efimov, Igor R.; Krinski, Valentin I.; Nikolski, Vladimir P., Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries.
Goldreyer Bruce N. (30311 Palos Verdes Dr. East Rancho Palos Verdes CA 90274), Method for spatially specific electrophysiological sensing for mapping, pacing and ablating human myocardium and a cathe.
Svenson Robert H. (Charlotte NC) King Wendell (North Oaks MN), Process of identification of a ventricular tachycardia (VT) active site and an ablation catheter system.
Tarjan,Peter P.; Lu,Chih Cheng; Besio,Walter, Single or multi-mode cardiac activity data collection, processing and display obtained in a non-invasive manner.
Ciaccio, Edward J.; Wit, Andrew L.; Tosti, Alexis Christine, System and method for determining reentrant ventricular tachycardia isthmus location and shape for catheter ablation.
Ciaccio,Edward J.; Wit,Andrew L.; Tosti,Alexis Christine, System and method for determining reentrant ventricular tachycardia isthmus location and shape for catheter ablation.
Rudy,Yoram; Ramanathan,Charulatha; Ghanem,Raja; Jia,Ping, System and methods for noninvasive electrocardiographic imaging (ECGI) using generalized minimum residual (GMRes).
Swanson David K. ; Whayne James G. ; Panescu Dorin, Systems and methods for acquiring making time-sequential measurements of biopotentials sensed in myocardial tissue.
Panescu Dorin ; Swanson David K. ; Mirotznik Mark S. ; Schwartzman David S. ; Foster Kenneth R., Systems and methods for examining the electrical characteristic of cardiac tissue.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.