[특허]Surface sampling concentration and reaction probe with controller to adjust sampling position

Surface sampling concentration and reaction probe with controller to adjust sampling position 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-001/02 G01N-001/32 G01N-001/38
출원번호	US-0936715 (2013-07-08)
등록번호	US-9395278 (2016-07-19)
발명자 / 주소	Van Berkel, Gary J. ElNaggar, Mariam S.
출원인 / 주소	UT-BATTELLE, LLC
대리인 / 주소	Fox Rothschild LLP
인용정보	피인용 횟수 : 0 인용 특허 : 23

초록 ▼

A method of analyzing a chemical composition of a specimen is described. The method can include providing a probe comprising an outer capillary tube and an inner capillary tube disposed co-axially within the outer capillary tube, where the inner and outer capillary tubes define a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe; contacting a target site on a surface of a specimen with a solvent in fluid communication with the probe; maintaining a plug volume proximate a solvent-specimen interface, wherein the plug volume is in fluid communication with the probe; draining plug sampling fluid from the plug volume through the sampling capillary; and analyzing a chemical composition of the plug sampling fluid with an analytical instrument. A system for performing the method is also described.

대표청구항 ▼

1. A system comprising for analyzing a chemical composition of a specimen comprising: a probe comprising:an outer capillary tube, andan inner capillary tube disposed co-axially within said outer capillary tube, said inner and outer capillary tubes defining a solvent capillary and a sampling capillary in fluid communication with one another at a distal end of the probe;the outer capillary tube having an inner diameter H, and h is a distance between a tip of said outer capillary and a tip of said inner capillary tube, solvent flowing through the solvent capillary forming a continuous liquid microjunction across the surface of the specimen spanning at least the inner diameter H of the outer capillary tube;an adjuster coupled to said outer capillary tube and said inner capillary tube, said adjuster for moving a tip of said outer capillary tube and a tip of said inner capillary tube longitudinally relative to one another; anda controller communicatively coupled to said adjuster, said controller being configured for actuating said adjuster to impart relative longitudinal motion between said outer capillary tube and said inner capillary tube, wherein the controller actuates said adjuster to maintain a plug volume proximate a solvent-specimen interface and within the liquid microjunction, the plug volume having a height less than h, wherein said plug volume is in fluid communication with said probe and the capillary ratio (h/H) exceeds 1.0. 2. The system according to claim 1, further comprising: an analytical instrument for determining a chemical composition of an analyte, wherein a sampling capillary is in fluid communication with said analytical instrument. 3. The system according to claim 2, wherein said analytical instrument is a mass spectrometer, an ionization source, a spectroscopy method; a separation method, or a combination thereof. 4. The system according to claim 2, further comprising: a specimen stage; anda stepper mechanism configured to provide relative motion between said specimen stage and said probe. 5. The system according to claim 4, wherein said stepper mechanism is communicatively coupled to said controller, said controller being configured for actuating said stepper to sequentially articulate said probe and said specimen stage along a predetermined sampling path comprising a plurality of target sites. 6. The system according to claim 4, wherein a chemical composition of an analyte desorbed at each of said plurality of target sites is determined by said analytical instrument and a plot of said data is generated. 7. The system according to claim 1, wherein the capillary ratio is at least 1.5. 8. The system according to claim 1, wherein the capillary ratio is at least 1.75. 9. The system according to claim 1, wherein the capillary ratio is at least 2.0. 10. The system according to claim 1, wherein the capillary ratio is from 1.0 to 2.0.

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Surface sampling concentration and reaction probe with controller to adjust sampling position 원문보기

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Surface sampling concentration and reaction probe with controller to adjust sampling position 원문보기

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