[특허]Crosslinked human or animal tissue products and their methods of manufacture and use

Crosslinked human or animal tissue products and their methods of manufacture and use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/39 A61P-043/00 A61P-001/02 A61P-017/02 A61P-015/02 A61L-027/24 A61K-038/17 A61K-038/16 A61L-027/36 A61L-027/54 A61L-027/58
출원번호	US-0560757 (2012-07-27)
등록번호	US-9399084 (2016-07-26)
발명자 / 주소	Mezger, W. Jerry Myers, Keith E.
출원인 / 주소	HARBOR MEDTECH, INC.
대리인 / 주소	Knobbe, Martens, Olson & Bear, LLP
인용정보	피인용 횟수 : 0 인용 특허 : 68

초록 ▼

Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.

대표청구항 ▼

1. A method of treating a tissue defect comprising: positioning a degradable bioprosthesis at, over, or into the tissue defect, wherein the degradable bioprosthesis comprises:a crosslinked collagen-based material comprising amine-based crosslinks and ester-based crosslinks;wherein the amount of free amines (—NH2) on the collagen based-material is between 50% and 85% relative to the total amount of free amines (—NH2) prior to crosslinking; andwherein the crosslinked collagen based material has a degradation rate between about 0.2% to about 1.0% per hour during the first 24 hours of exposure to a pronase digestion assay. 2. The method of claim 1, wherein the tissue defect is a tendon defect. 3. The method of claim 1, wherein the tissue defect is a ligament defect. 4. The method of claim 1, wherein the tissue defect is vaginal prolapse. 5. The method of claim 1, wherein the tissue defect is a hernia. 6. The method of claim 1, wherein the tissue defect causes urinary incontinence. 7. The method of claim 1, wherein the tissue defect is a gum defect. 8. The method of claim 1, wherein the tissue defect is an organ defect. 9. The method of claim 1, wherein the tissue defect is as a result of bariatric surgery. 10. The method of claim 1, wherein the tissue defect is a wound. 11. The method of claim 1, wherein the degradable bioprosthesis is derived from animal pericardium. 12. The method of claim 1, wherein the degradable bioprosthesis is attached to the tissue defect. 13. The method of claim 1, wherein the degradable bioprosthesis comprises a flexible sheet. 14. The method of claim 13, wherein the flexible sheet is between about 1 cm2 and about 500 cm2. 15. The method of claim 13, wherein the flexible sheet is treated with antimicrobial agent. 16. The method of claim 1, wherein the degradable bioprosthesis comprises a crosslinked collagen-based material comprising Crosslink A and Crosslink B, wherein: indicates collagen strands;R1 is R2 is R3 and R4 are independently selected from the group consisting of —CH2—O—(CH2)n—O—CH2— and —CH2—(O(CH2)n)m—O—CH2—, andn and m are independently an integer from 1-6. 17. The method of claim 16, wherein the degradable bioprosthesis has a shrinkage temperature (Ts) above about 70° C. 18. The method of claim 16, wherein the ratio of Crosslink A and Crosslink B is from about 100:1 to about 1:100. 19. A method of treating a wound comprising: identifying a patient in need of a degradable bioprosthesis to aid in the healing of a wound;determining an approximate rate of healing of the wound;selecting a degradable bioprosthesis comprising a tailorably crosslinked collagen-based material having a degradation rate similar to the rate of healing of the wound; andimplanting the degradable bioprosthesis over or into the wound. 20. A method of treating a wound comprising: providing a biologic skin substitute comprising partially crosslinked collagen; and placing the skin substitute over a wound, wherein the degradation of the skin substitute progresses at or about the same rate as the wound heals; wherein the biologic skin substitute comprises amine-based crosslinks and ester-based crosslinks; wherein the amount of free amines (—NH2) on the collagen-based material is between 50% and 85% relative to the total amount of free amines (—NH2) prior to crosslinking. 21. The method of claim 20, wherein the degradation rate of the skin substitute is such that the skin substitute degrades completely within the range of time between about 8 weeks and about 1 year.

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Crosslinked human or animal tissue products and their methods of manufacture and use 원문보기

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Crosslinked human or animal tissue products and their methods of manufacture and use 원문보기

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