Methods of inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/785
A61K-009/00
A61K-009/70
B27K-003/15
B27K-003/22
B27K-003/26
B27K-003/28
출원번호
US-0103353
(2008-04-15)
등록번호
US-9402860
(2016-08-02)
발명자
/ 주소
Kovacs, Stephen G.
Chesson, Jerry
출원인 / 주소
Chesson Laboratory Associates, Inc.
대리인 / 주소
Myers Bigel & Sibley, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
43
초록
A method for treating onychomycosis and skin conditions such as urushiol-induced allergic contact dermatitis comprises coating the affected nail or skin with a solution comprising an at least a primary diamine with modified diphenylmethane diisocyanates and a carrier solvent/reactant.
대표청구항▼
1. A method of treating onychomycosis and/or urashiol-induced contact dermatitis comprising topically applying a composition comprising (i) a primary diamine comprising a polyether segment;(ii) a secondary aromatic diamine;(iii) a polyisocyanate; and(iv) optionally, a polyol,and/or a reaction produc
1. A method of treating onychomycosis and/or urashiol-induced contact dermatitis comprising topically applying a composition comprising (i) a primary diamine comprising a polyether segment;(ii) a secondary aromatic diamine;(iii) a polyisocyanate; and(iv) optionally, a polyol,and/or a reaction product thereof. 2. The method of claim 1, wherein topically applying the composition comprises forming a solution comprising the primary diamine, the secondary aromatic diamine, the polyisocyanate, and optionally, the polyol; and/or a reaction product thereof; andcoating an affected nail or skin with the solution. 3. The method of claim 2, wherein topically applying the composition further comprises drying the solution to form a polyurea, and/or polyureathane polymer. 4. The method of claim 3, wherein the primary diamine comprises polyoxypropylenediamine. 5. The method of claim 3, wherein the secondary aromatic diamine comprises N,N′-dialkylaminodiphenylmethane. 6. The method of claim 5, wherein the secondary aromatic diamine comprises bis(sec-butylamino)diphenylmethane. 7. The method of claim 3, wherein the polyisocyanate comprises at least one of diphenymethanediisocyanate (MDI), a polyisocyanate, MDI containing resin, aliphatic diisocyanates, aromatic diisocyanates, alicyclic diisocyanates, ethylene diisocyanate, ethylidene diisocyanate, propylene diisocyanaie, butylene diisocyanate, cyclopentylene-1,3-diisocyanate, cyclohexylene-1,4,diisocyanate, cyclohexylene-1,2-diisocyanate, 2,4-tolylene diisocyanate, 2,6-tolylene diisocyanate, 4,4′-diphenylmethane diisocyanate, 2,2-diphenylpropane-4,4′-diisocyanate, p-phenylene diisocyanate, m-phenylene diisocyanate, xylylene diisocyanate, 1,4-naphthylene diisocyanate, 1,5-naphthylene diisocyanate, diphenyl-4,4′-diisocyanate, azobenzene-4,4′diisocyanate, diphenylsulfone-4,4′diisocyanate, dichlorohexamethylene diisocyanate, tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, 1-chlorobenzene-2,4-diisocyanate, furfurylidene diisocyanate and triphenylmethane triisocyanate. 8. The method of claim 7, wherein the polyisocyanate comprises MDI, a polyisocyanate adduct and/or a MDI containing resin. 9. The method of claim 8, wherein the polyisocyanate comprises a carbodiimide modified MDI. 10. The method of claim 3, wherein the polyol comprises at least one of ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 2,3-butylene glycol, a propylene oxide adduct of trimethylol propane, polyethylene glycol. 11. The method of claim 10, wherein the polyol comprises at least one of ethylene glycol, propylene glycol and a propylene oxide adduct of trimethylol propane. 12. The method of claim 1, wherein the composition further comprises at least one solvent selected from the group consisting of acetone, methyl ethyl ketone, methylisobutylketone, N-methylcyclohexanone, acetaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde, methyl acetate, ethyl acetate, butyl acetate, and methyl propyl acetate. 13. The method of claim 1, wherein the volume ratio of the primary diamine ranges from about 3.6% to about 12.2% v/v, based on the total volume of the composition. 14. The method of claim 1, wherein the volume ratio of the secondary aromatic diamine ranges from about 0.6% to about 6.8% v/v, based on the total volume of the composition. 15. The method of claim 1, wherein the ratio of the primary and secondary diamine to the polysicoyanate is from about 2.8:1 to about 3.8:1 by volume. 16. The method of claim 1, wherein the composition further comprises a colorant and/or pigment.
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