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A surgical fastening apparatus includes a fastener retaining frame having a first annular portion having a plurality of retainers circumferentially disposed thereon and a second annular portion having a plurality of circumferentially arranged perforations. The fastener retaining frame is detachably

A surgical fastening apparatus includes a fastener retaining frame having a first annular portion having a plurality of retainers circumferentially disposed thereon and a second annular portion having a plurality of circumferentially arranged perforations. The fastener retaining frame is detachably secured to a supporting structure. After the plurality of surgical fasteners has been mated with the plurality of retainers, an annular blade severs the perforations.

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1. An end effector of a surgical instrument comprising: a tubular body including a plurality of surgical fasteners therein;an anvil movable relative to the tubular body between an open position and an approximated position;a fastener retaining frame including a first annular portion having a weakene

1. An end effector of a surgical instrument comprising: a tubular body including a plurality of surgical fasteners therein;an anvil movable relative to the tubular body between an open position and an approximated position;a fastener retaining frame including a first annular portion having a weakened portion and a second annular portion having a plurality of retainers configured to mate with the plurality of surgical fasteners to retain tissue therebetween; anda flange secured with the anvil, the flange defining a circular recess configured to receive a portion of the first annular portion therein, the flange including a circular ledge extending radially over the portion of the first annular portion to secure the portion of the first annular portion within the circular recess of the flange, wherein the weakened portion is severable from the plurality of retainers, whereby the plurality of the retainers is detachable from the anvil and the portion of the first annular portion is retained within the circular recess of the flange. 2. The end effector of the surgical instrument according to claim 1, wherein the plurality of retainers is circumferentially arranged on the second annular portion of the fastener retaining frame. 3. The end effector of the surgical instrument according to claim 2, wherein the weakened portion is circumferentially arranged in the first annular portion of the fastener retaining frame. 4. The end effector of the surgical instrument according to claim 3, wherein the first and second annular portions are concentrically arranged. 5. The end effector of the surgical instrument according to claim 3, wherein the first annular portion is disposed within the second annular portion. 6. The end effector of the surgical instrument according to claim 1, wherein the plurality of retainers is monolithically formed. 7. The end effector of the surgical instrument according to claim 1, wherein the plurality of retainers is arranged circumferentially on the fastener retaining frame to define two concentric rings of retainers. 8. The end effector of the surgical instrument according to claim 7, wherein the weakened portion is disposed radially inward of the two concentric rings of retainers. 9. The end effector of the surgical instrument according to claim 1, wherein each retainer of the plurality of retainers defines a pair of cavities configured to receive prongs of the respective surgical fasteners. 10. The end effector of the surgical instrument according to claim 9, wherein each cavity includes a notch, and each prong includes a protrusion configured to engage the notch. 11. The end effector of the surgical instrument according to claim 1, wherein the weakened portion defines a plurality of perforations formed therein. 12. The end effector of the surgical instrument according to claim 1, wherein the tubular body further includes an annular pusher for ejecting the plurality of surgical fasteners toward the respective retainers. 13. The end effector of the surgical instrument according to claim 1, wherein the tubular body further includes an annular blade for severing the weakened portion of the fastener retaining frame to detach the plurality of retainers of the fastener retaining frame from the anvil. 14. The end effector of a surgical instrument according to claim 1, wherein the circular ledge extends radially outward from an inner-most portion of the flange. 15. A method of fastening tissue comprising: providing an end effector of a surgical instrument including: a tubular body;an anvil;a fastener retaining frame including a plurality of retainers configured to mate with respective surgical fasteners, and a weakened portion; anda flange secured with the anvil, the flange defining a circular recess configured to receive a portion of the fastener retaining frame, the flange including a circular ledge extending radially over the portion of the fastener retaining frame to secure the portion of the fastener retaining frame within the circular recess of the flange;positioning tissue between the tubular body and the anvil;applying the surgical fasteners through the tissue; anddetaching the plurality of the retainers from the anvil, such that the portion of the fastener retaining frame is retained within the circular recess of the flange. 16. The method of fastening tissue according to claim 15, wherein detaching the plurality of the retainers from the anvil includes severing the weakened portion of the fastener retaining frame. 17. The method of fastening tissue according to claim 16, wherein detaching the plurality of the retainers from the anvil includes severing the weakened portion of the fastener retaining frame by an annular blade operatively disposed in the end effector. 18. The method of fastening tissue according to claim 15, wherein applying the surgical fasteners through the tissue includes engaging the surgical fasteners with the respective retainers. 19. The method of fastening tissue according to claim 15, further comprising clamping the tissue between the tubular body and anvil by moving the anvil toward the tubular body.