Capsule and method for treating or diagnosing conditions or diseases of the intestinal tract
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/06
A61B-005/00
A61B-001/04
A61B-005/07
A61B-005/03
A61B-005/11
A61B-005/145
A61M-005/172
A61M-031/00
A61B-001/00
A61N-001/36
A61N-001/372
출원번호
US-0215182
(2011-08-22)
등록번호
US-9414768
(2016-08-16)
발명자
/ 주소
Imran, Mir A.
출원인 / 주소
Entrack, Inc.
대리인 / 주소
Mahamedi IP Law LLP
인용정보
피인용 횟수 :
1인용 특허 :
62
초록▼
A device and method for mapping, diagnosing and treating inflammatory disorders (such as Crohn's disease) or other diseases, disorders or conditions of the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a
A device and method for mapping, diagnosing and treating inflammatory disorders (such as Crohn's disease) or other diseases, disorders or conditions of the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed impedance and or temperature may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose, or mark the intestinal tract at a determined location along its length.
대표청구항▼
1. A method for diagnosing an inflammatory gastrointestinal disorder comprising: providing an autonomous capsule comprising an impedance sensor for implementation within a gastrointestinal tract, wherein the impedance sensor is configured to detect an electrical impedance by providing a voltage acro
1. A method for diagnosing an inflammatory gastrointestinal disorder comprising: providing an autonomous capsule comprising an impedance sensor for implementation within a gastrointestinal tract, wherein the impedance sensor is configured to detect an electrical impedance by providing a voltage across two electrodes of the sensor, the capsule further comprising a deployment mechanism wrapped at least partially around the capsule which is expandable to bring the two electrodes of the impedance sensor into contact with a wall of the gastrointestinal tract to detect the electrical impedance;sensing, with the impedance sensor, one or more impedances at a first impedance location within the gastrointestinal tract while the capsule is being tracked by providing at least one voltage across the two electrodes at the first impedance location, each at least one voltage having a frequency between 10 kHz and 100 Hz which is different from the other at least one voltages;sensing, with the impedance sensor, one or more impedances at a second impedance location within the gastrointestinal tract while the capsule is being tracked by providing the at least one voltage across the two electrodes at the second impedance location;determining, for each voltage of the at least one voltages, whether the sensed impedance at the first impedance location is different from the sensed impedance at the second impedance location by more than a predetermined difference; andin response to determining, for a voltage of the at least one voltages, that a sensed impedance at the first impedance location is different from a sensed impedance at the second impedance location by more than the predetermined difference, spraying, from the autonomous capsule, a marking agent on the second impedance location, the marking agent to pinpoint the second impedance location for at least one of diagnosis or surgery. 2. The method of claim 1 wherein sensing the one or more impedances by providing the at least one voltage comprises providing three voltages having frequencies of 10 kHZ, 1 kHz and 100 Hz. 3. The method of claim 1, further comprising: providing, in the autonomous capsule, a temperature sensor;sensing, with the temperature sensor, a temperature at a first temperature location within the gastrointestinal tract;sensing, with the temperature sensor, a temperature at a second temperature location within the gastrointestinal tract;determining whether the temperature at the first temperature location is different from the temperature at the second temperature location by a predetermined difference; andin response to determining that the temperature at the first temperature location is different from the temperature at the second temperature location, spraying, from the autonomous capsule, a marking agent on the second temperature location, the marking agent to pinpoint the second impedance location for at least one of diagnosis or surgery. 4. The method of claim 3, further comprising: sensing the impedance at a plurality of impedance locations within the gastrointestinal tract;mapping the sensed impedance with respect to each of the plurality of impedance locations;sensing the temperature at a plurality of temperature locations with gastrointestinal tract; andmapping the sensed temperature with respect to each of the plurality of temperature locations;wherein one or more locations corresponding to one or more of a temperature anomaly or an impedance anomaly is marked with the marking agent. 5. The method of claim 1, wherein the marking agent includes one or more of a radiopaque marker, a fluorescing compound, or a dye. 6. The method of claim 1, further comprising detecting a gastrointestinal disorder by, in response to determining, for each voltage of the at least one voltages, whether the sensed impedance at the first impedance location is different from the sensed impedance at the second impedance location by more than a predetermined difference: comparing the sensed impedances on a map by weighing the sensed impedances for lower frequencies more than sensed impedances for higher frequencies. 7. A method for diagnosing a gastrointestinal disorder, comprising: providing an autonomous capsule comprising an impedance sensor to a patient, the autonomous capsule for implementation within a patient's gastrointestinal tract, wherein the impedance sensor is configured to detect an electrical impedance by providing a voltage across two electrodes of the sensor, the capsule further comprising a deployment mechanism wrapped at least partially around the capsule which is expandable to bring the two electrodes of the impedance sensor into contact with a wall of the gastrointestinal tract to detect the electrical impedance;sensing, with the impedance sensor, one or more impedance values for a first location in the gastrointestinal tract by providing at least one voltage across the two electrodes at the first impedance location, each at least one voltage having a frequency between 10 kHz and 100 Hz which is different from the other at least one voltages;sensing, with the impedance sensor, one or more second impedance values for a second location in the gastrointestinal tract by providing the at least one voltage across the two electrodes at the second impedance location;computing, for each voltage of the at least one voltages, an impedance difference between the first impedance value and the second impedance value; anddetermining a location of the gastrointestinal disorder by comparing the impedance differences with a first predetermined value; andin response to determining the location of the gastrointestinal disorder, spraying, from the autonomous capsule, a marking agent on the determined location, the marking agent to pinpoint the determined location for at least one of diagnosis or surgery. 8. The method of claim 7, wherein sensing the one or more impedance values by providing the at least one voltage comprises providing three voltages having frequencies of 10 kHZ, 1 kHz and 100 Hz. 9. The method of claim 7, further comprising: providing, in the autonomous capsule, a temperature sensor;sensing, with the temperature sensor, a first temperature value for a first portion of the gastrointestinal tract;sensing, with the temperature sensor, a second temperature value for a second portion of the gastrointestinal tract; andcomputing a temperature difference between the first and second temperature values,wherein the determination of the location of the gastrointestinal disorder is further based on a second comparison between the temperature difference and a second predetermined value. 10. The method of claim 9, further comprising: measuring a plurality of temperature values at a plurality of temperature locations within the gastrointestinal tract; andmeasuring, for each of the plurality of temperature locations, a distance traveled by the autonomous capsule;constructing a temperature map of the gastrointestinal tract of the patient based on the measured distances and the measured temperature values with respect to each of the plurality of temperature locations. 11. The method of claim 7, wherein the marking agent includes one or more of a radiopaque marker, a fluorescing compound, or a dye. 12. The method of claim 7, wherein determining the location of the gastrointestinal disorder comprises: comparing the sensed on a map by weighing the impedances for lower frequencies more than sensed impedances for higher frequencies.
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