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특허 상세정보

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Platinum-catalyzed intravaginal rings

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-009/00    A61K-031/505    A61K-031/444   
출원번호 US-0051544 (2013-10-11)
등록번호 US-9427400 (2016-08-30)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    McCarter & English, LLP
인용정보 피인용 횟수 : 0  인용 특허 : 64
초록
▼

The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matr...

대표
청구항
▼

1. A platinum-catalyzed silicone intravaginal matrix-type ring comprising a non-nucleoside reverse transcriptase inhibitor (NNRTI), wherein between about 1 mg and about 3 mg of said NNRTI is released in vitro from said ring during an initial 24 hour period of release, wherein between about 100 and about 500 micrograms of said NNRTI is released in vitro each day for 21 days after an initial 7 day period of release, and wherein the NNTRI is homogenously distributed throughout the ring. 2. The platinum-catalyzed silicone intravaginal ring of claim 1, wherei...

이 특허에 인용된 특허 (64)

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