[특허]System and method for microfluidic flow control

System and method for microfluidic flow control 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	F16K-011/20 F17D-001/00 B01L-003/00 F16K-099/00
출원번호	US-0606392 (2015-01-27)
등록번호	US-9427736 (2016-08-30)
발명자 / 주소	Zeng, Shulin Dale, Gregory A.
출원인 / 주소	Canon U.S. Life Sciences, Inc.
대리인 / 주소	Rothwell, Figg, Ernst & Manbeck, P.C.
인용정보	피인용 횟수 : 0 인용 특허 : 28

초록 ▼

A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.

대표청구항 ▼

1. A system for sequentially introducing predetermined amounts of different reaction fluids into a microfluidic circuit comprising: a. a microfluidic circuit comprising a microchannel, a plurality of inlet ports in fluid communication with the microchannel and through which different reaction fluids are introduced into the microchannel and an outlet port in fluid communication with the microchannel through which fluid from the microchannel is collected;b. at least one pressure source in selective communication with said outlet port and said plurality of inlet ports; andc. at least one valve mechanism operatively associated with said plurality of inlet ports and in communication with said pressure source, each valve mechanism being adapted to sequentially connect each of said plurality of inlet ports to a pressure generated by said pressure source for a predetermined period of time, causing a predetermined amount of fluid to flow from the inlet port into the microchannel, and then connecting said inlet port to a different pressure to substantially stop the flow of fluid. 2. The system of claim 1 wherein, said at least one pressure source comprises a vacuum pump, said first pressure is a negative pressure generated by said vacuum pump, and said second pressure comprises atmospheric pressure. 3. The system of claim 1, wherein said at least one pressure source comprises a first pump for generating said first pressure and a second pump for generating said second pressure. 4. The system of claim 1, further comprising a controller adapted to control the operation of said pressure source and said valve mechanism and to cause: (i) said pressure source to apply said first pressure to said outlet port and to(ii) cause said valve mechanism to open one of said plurality of inlet ports to said second pressure to cause fluid to flow from said inlet port into said microchannel and,(iii) after said inlet port has been open to said second pressure for a pre-determined period of time, to cause said valve mechanism to close said inlet port to said second pressure and open said inlet port to said first pressure for a predetermined period of time and to shut off the valve mechanism to said inlet port to stop flow from said inlet port into said microchannel;wherein said controller causes (ii) and (iii) to repeat for each of said plurality of inlet ports. 5. The system of claim 1, wherein said valve mechanism comprises a three-way valve adapted to selectively communicate each of said plurality of inlet ports with either said second pressure or said first pressure. 6. The system of claim 1, wherein said valve mechanism comprises a first two-way valve constructed and arranged to selectively open each of said plurality of inlet ports to said second pressure or close said inlet port to said second pressure and a second two-way valve constructed and arranged to selectively open said inlet port to said first pressure or close said inlet port to said first pressure. 7. The system of claim 1, wherein said pressure source comprises a single vacuum pump in selective communication with both said outlet port and said valve mechanism. 8. The system of claim 7, further comprising an outlet valve mechanism operatively associated with said outlet port and adapted to selectively connect said outlet port to said pressure source. 9. The system of claim 1, wherein said microfluidic circuit comprises a chip made from glass, silica, quartz, or plastic. 10. The system of claim 1, wherein said valve mechanism comprises a solenoid valve.

이 특허에 인용된 특허 (28)

Covington, Joseph F.; Hobbs, Steven E.; Koehler, Jeffrey A.; Patel, Paren P.; Pezzuto, Marci; Scheib, Mark S., Adhesiveless microfluidic device fabrication.
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Brown,Timothy B.; Kurth,Richard, Flow control of photo-polymerizable resin.
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O'Connor, Stephen D.; Dantsker, Eugene; Pezzuto, Marci, Fluidic impedances in microfluidic system.
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Quake, Stephen R.; Chou, Hou-Pu, Integrated active flux microfluidic devices and methods.
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Marja Liisa Alajoki ; H. Garrett Wada ; Robert S. Dubrow, Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection.
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Moles Donald R., Method of making a fluid flow module.
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Spence,Charles F.; Fu,Anne Y.; Quake,Stephen R.; Arnold,Frances H., Microfabricated cell sorter.
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Quake,Stephen R.; Thorsen,Todd, Microfabricated crossflow devices and methods.
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Fernandes, David N.; Chou, Hou-Pu; Unger, Marc A., Microfabricated fluidic circuit elements and applications.
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Fernandes, David N.; Chou, Hou-Pu; Unger, Marc A., Microfabricated fluidic circuit elements and applications.
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Chou,Hou Pu; Fu,Anne Y.; Quake,Stephen R., Microfluidic devices and methods of use.
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Young, Lincoln; Zhou, Peng, Microfluidic pump and valve structures and fabrication methods.
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O'Connor, Stephen D.; Karp, Christoph D., Microfluidic regulating device.
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Gilbert, John Richard; B?hm, Sebastian; Deshpande, Manish, Microfluidic system including a bubble valve for regulating fluid flow through a microchannel.
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Chien, Ring-Ling; Parce, J. Wallace; Chow, Andrea W.; Kopf-Sill, Anne, Multi-reservoir pressure control system.
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Mathies, Richard A.; Grover, William H.; Jensen, Erik C., Multiplexed latching valves for microfluidic devices and processors.
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Colin B. Kennedy, Multiplexed microfluidic devices, systems, and methods.
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Parce, J. Wallace; Chow, Andrea W., Non-mechanical valves for fluidic systems.
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Nikiforov,Theo T.; Baker,Jill M.; Lin,Sansan; Parce,J. Wallace, Pressure-based mobility shift assays.
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Paul, Carlton H.; Praria, Guy B.; Stokes, Jeffrey H., Programmable tracking pressure regulator for control of higher pressures in microfluidic circuits.
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McNeely, Michael R.; Spute, Mark K., Remote valving for microfluidic flow control.
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Christopher J. Backhouse CA; Herbert A. Hartshorne CA, Sealed microfluidic devices.
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LaBudde, Edward V.; Queeney, Jr., Paul J., State-variable control system.
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Zeng, Shulin; Dale, Gregory A., System and method for microfluidic flow control.
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Pan Jeffrey Y. ; Lee Donald Ver, Valve control.
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Brody James P., Valveless liquid microswitch.
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