Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/395
A61K-009/127
G01N-033/574
A61K-031/7034
A61K-031/7048
C12Q-001/68
A61K-047/48
A61K-051/10
C07K-016/40
출원번호
US-0520962
(2014-10-22)
등록번호
US-9429576
(2016-08-30)
발명자
/ 주소
Waldman, Scott A.
Park, Jason
Schulz, Stephanie
출원인 / 주소
Thomas Jefferson University
대리인 / 주소
Pepper Hamilton LLP
인용정보
피인용 횟수 :
0인용 특허 :
65
초록▼
Screening and diagnostic reagents, kits and methods for primary and or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating a
Screening and diagnostic reagents, kits and methods for primary and or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing primary and/or metastatic stomach for esophageal cancer are disclosed.
대표청구항▼
1. A method of treating an individual suspected of suffering from primary and/or metastatic stomach or esophageal cancer comprising the step of administering to said individual a therapeutically effective amount of a composition comprising a liposome with an outer liposomal surface that comprises an
1. A method of treating an individual suspected of suffering from primary and/or metastatic stomach or esophageal cancer comprising the step of administering to said individual a therapeutically effective amount of a composition comprising a liposome with an outer liposomal surface that comprises an anti-guanylyl cyclase C antibody which binds to SEQ ID NO:2 associated with the outer liposomal surface and an active agent is encapsulated within the liposome. 2. The method of claim 1 wherein the anti-guanylyl cyclase C antibody is conjugated to the active agent. 3. The method of claim 1 wherein the anti-guanylyl cyclase C antibody and the active agent are unconjugated. 4. The method of claim 1 wherein the anti-guanylyl cyclase C antibody is a monoclonal antibody. 5. The method of claim 1 wherein the anti-guanylyl cyclase C antibody is a FAb or a F(Ab)2. 6. The method of claim 1 wherein the active agent is a therapeutic agent. 7. The method of claim 6 wherein said therapeutic agent is selected from the group consisting of: chemotherapeutics, toxins and radiosensitizing agents. 8. The method of claim 6 wherein said therapeutic agent is selected from the group consisting of: compounds that cause cell death, compounds that inhibit cell division, and compounds that induce cell differentiation. 9. The method of claim 6 wherein said therapeutic agent is selected from the group consisting of: methotrexate, doxorubicin, daunorubicin, cytosinarabinoside, etoposide, 5-fluorouracil, melphalan, chlorambucil, cis-platinum, vindesine, mitomycin, bleomycin, purothionin, macromomycin, 1,4-benzoquinone derivatives, trenimon, ricin, ricin A chain Pseudomonas exotoxin, diphtheria toxin, Clostridium perfringens phospholipase C, bovine pancreatic ribonuclease, pokeweed antiviral protein, abrin, abrin A chain, cobra venom factor, gelonin, saporin, moceccin, viscumin, vokensin, alkaline phosphatase, nitroimidazole, metronidazole, misonidazole, 47Sc, 67Cu, 90Y, 109Pd, 123I, 131I, 186Re, 188Re, 199Au, 211At, 212Pb, 212B, 32P and 33P, 71Ge, 77As, 103Pb, 105Rh, 111Ag, 119Sb, 121Sn, 131Cs, 143Pr, 161Tb, 177Lu, 191Os, 193MPt, 197Hg, 43K, 52Fe, 57Co, 67Cu, 68Ga, 77Br, 81Rb/81MKr, 87MSr, 99MTc, 111In, 113MIn, 123I, 125I, 127Cs, 129Cs, 131I, 132I, 197Hg, 203Pb and 206Bi. 10. The method of claim 1 wherein said composition is administered to said individual by injection. 11. The method of claim 1 wherein said composition is administered to said individual intravenously. 12. The method of claim 1 wherein said individual has been diagnosed as having primary esophageal cancer. 13. The method of claim 1 wherein said individual has been diagnosed as having metastatic esophageal cancer. 14. The method of claim 1 wherein said individual has been diagnosed as having primary stomach cancer. 15. The method of claim 1 wherein said individual has been diagnosed as having metastatic stomach cancer. 16. The method of claim 6, wherein said therapeutic agent is a chemotherapeutic agent selected from the group consisting of methotrexate, doxorubicin, daunorubicin, cytosinarabinoside, etoposide, 5-4 fluorouracil, melphalan, chlorambucil, cis-platinum, vindesine, mitomycin, bleomycin, 1,4-benzoquinone derivatives, macromomycin, nitroimidazole, metronidazole, and misonidazole. 17. The method of claim 6, wherein said therapeutic agent is a toxin selected from the group consisting of trenimon, ricin, ricin A chain, Pseudomonas exotoxin, diphtheria toxin, Clostridium perfringens phospholipase C, bovine pancreatic ribonuclease, pokeweed antiviral protein, abrin, abrin A chain, cobra venom factor, gelonin, saporin, modeccin, viscumin, volkensin and purothionin. 18. The method of claim 6, wherein said therapeutic agent is a radiotherapeutic agent selected from the group consisting of 47Sc, 67Cu, 90Y, 109Pd, 123I, 131I, 186Re, 188Re, 199Au, 211At, 212Pb, 212B, 32P and 33P, 71Ge, 77As, 103Pb, 105Rh, 111Ag, 119Sb, 121Sn, 131Cs, 143Pr, 161Tb, 177Lu, 191Os, 193MPt, 197Hg, 43K, 52Fe, 57Co, 67Cu, 67Ga, 68Ga, 77Br, 81Rb/81MKr, 87MSr, 99MTc, 111In, 113MIn, 127Cs, 129Cs, 132I, 197Hg, 203Pb and 206Bi.
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