Thermoelectric sensor for analytes in a gas and related method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-015/06
G01N-033/64
A61B-005/097
G01N-033/497
G01N-033/98
G01N-027/26
G01N-025/20
G01N-025/00
G01N-025/48
G01D-001/06
G01N-015/02
G01N-021/03
G01N-021/3504
G01N-021/78
G01N-021/84
G01N-031/22
G01N-033/68
G01N-001/22
출원번호
US-0274844
(2014-05-12)
등록번호
US-9429578
(2016-08-30)
발명자
/ 주소
Ahmad, Lubna
출원인 / 주소
Invoy Technologies, LLC
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
0인용 특허 :
65
초록▼
An apparatus is provided for sensing an analyte in a fluid. The apparatus includes a fluid collecting device configured to collect the fluid containing the analyte; a fluid input in fluid communication with the fluid collecting device configured to input the fluid containing the analyte into the flu
An apparatus is provided for sensing an analyte in a fluid. The apparatus includes a fluid collecting device configured to collect the fluid containing the analyte; a fluid input in fluid communication with the fluid collecting device configured to input the fluid containing the analyte into the fluid collecting device, an analyte interactant in fluid communication with the fluid collecting device, wherein the analyte interactant, when contacted by the analyte, reacts to cause a first change in thermal energy within the fluid collecting device; a modulator that causes a second change in thermal energy; a thermal sensing device comprising at least one pyroelectric device thermally coupled to the fluid collecting device to generate a first signal in response to at least one of the first change in thermal energy and the second change in thermal energy; a control device operatively coupled to the thermal sensing device and the modulator that generates a second signal, wherein the second signal comprises information useful in characterizing the analyte. A related method also is disclosed.
대표청구항▼
1. A biosensor for detecting at least one analyte in breath, the biosensor comprising: a) a capture apparatus; andb) a thermoelectric sensor without a power source, the sensor comprising a layer of at least one analyte interactant that increases or decreases in temperature and at least one thermopil
1. A biosensor for detecting at least one analyte in breath, the biosensor comprising: a) a capture apparatus; andb) a thermoelectric sensor without a power source, the sensor comprising a layer of at least one analyte interactant that increases or decreases in temperature and at least one thermopile, said at least one thermopile having a first contact pad and a second contact pad; andwherein the passage of breath containing the analyte through the capture apparatus brings the analyte into contact with the interactant and produces or consumes heat, which is transmitted to the thermopile that then produces a voltage difference and measures the analyte. 2. The biosensor of claim 1, wherein the interactant is selected from a chemical reactant, catalyst, adsorbent, absorbent, vaporization agent or a combination thereof. 3. The biosensor of claim 1, wherein the biosensor further comprises multiple thermopiles, each having the same or different interactants. 4. The biosensor of claim 1, wherein the interactant is selected from sodium hypochlorite sodium monochloroisocyanurate, sodium trichloroisocyanurate, salt, nitrosyl chloride, chloroform or a combination thereof. 5. The biosensor of claim 1, wherein the microprocessor also communicates with an electronic display, noise maker, other output or a combination thereof. 6. The biosensor of claim 1, wherein the analyte is acetone, whose presence indicates the presence of ketones in the bloodstream. 7. The biosensor of claim 1, wherein the analyte is alcohol and the interactant is selected from chromium trioxide, alcohol dehydrogenase, alcohol oxidase, acetoalcohol oxidase or a combination thereof. 8. The biosensor of claim 1, wherein the interactants are specific for ethanol and alkanes, thereby indicating various pathologies, such as breast cancer and transplant rejection. 9. The biosensor of claim 1, wherein the thermopile comprises metals, alloys, semiconductor materials, or liquid thermoelectric materials. 10. The biosensor of claim 1, wherein the analyte interactant comprises biologically active materials comprising cells, cell organelles, microorganisms or genetically modified organisms. 11. A method of detecting an analyte in breath by thermoelectric sensor, the method comprising a) providing a thermoelectric sensor without a power source, the sensor comprising i) a layer of at least one analyte interactant that when combined with the analyte, gives off or consumes heat; andii) at least one thermopile to which the heat change is transferred, which then registers a voltage difference, the at least one thermopile having a first contact pad and a second contact pad;b) passing a breath sample containing the airborne analyte over the thermoelectric sensor; andc) indicating the presence or quantity of the analyte. 12. The method of claim 11, wherein the step a of providing the thermoelectric sensor comprises providing an analyte interactant specific for acetone and step c comprises a display indicating the presence of acetone, whereby lipid metabolism is indicated. 13. The method of claim 11, wherein the provided thermoelectric sensor has multiple thermopiles, each having the same or different analyte interactants, whereby the presence of single or multiple analytes are indicated. 14. The biosensor of claim 1, wherein the biosensor further comprises c) a microprocessor attached to first ends of a first lead and a second lead, the first lead having a second end attached to said first thermopile contact pad and the second lead having a second end attached to said second thermopile contact pad,whereby the voltage difference produced by the thermopile is registered in the microprocessor, which converts the voltage so as to measure the analyte. 15. The biosensor of claim 14, wherein multiple thermopiles, each having the same or different interactants, are each independently connected to the microprocessor via two leads. 16. The method of claim 11, wherein the thermoelectric sensor provided in step a. further comprises: iii) a microprocessor attached to first ends of a first lead and a second lead, the first lead having a second end attached to the first thermopile contact pad and the second lead having a second end attached to the second thermopile contact pad, the microprocessor also communicating with a signal device. 17. The method of claim 16, wherein the provided thermoelectric sensor has multiple thermopiles, each having the same or different analyte interactants and each being connected to the microprocessor by two leads, whereby the presence of single or multiple analytes are indicated.
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