Implantable medical device having enhanced endothelial migration features and methods of making the same
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/86
A61F-002/82
A61F-002/90
A61F-002/91
A61F-002/00
A61F-002/01
A61F-002/06
A61F-002/24
출원번호
US-0156017
(2014-01-15)
등록번호
US-9439789
(2016-09-13)
발명자
/ 주소
Palmaz, Julio C.
출원인 / 주소
Palmaz Scientific, Inc.
대리인 / 주소
Rotman, Benjamin D.
인용정보
피인용 횟수 :
0인용 특허 :
64
초록▼
An implantable medical device having enhanced endothelial migration features, generally comprises: a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a second surface region in a generally curvilinear cross-section, a
An implantable medical device having enhanced endothelial migration features, generally comprises: a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a second surface region in a generally curvilinear cross-section, and the trailing edge including a fourth surface region in a generally curvilinear cross-section, whereby blood flow over the second surface region generate shear stress at the second surface region without an eddy region in the second surface region.
대표청구항▼
1. A tubular implantable medical device having enhanced endothelial migration features, comprising: a plurality of structural members,each of the plurality of structural members having an irregular polygonal transverse cross-sectional profile,wherein each facet of the irregular polygonal transverse
1. A tubular implantable medical device having enhanced endothelial migration features, comprising: a plurality of structural members,each of the plurality of structural members having an irregular polygonal transverse cross-sectional profile,wherein each facet of the irregular polygonal transverse cross-sectional profile defines a surface of the plurality of structural members,wherein the defined surfaces of the plurality of structural members make up abluminal surfaces engaged with a vessel and luminal surfaces exposed to a blood flow,wherein the luminal surfaces form a transverse cross-sectional profile comprising a concave curvilinear second surface region and a concave curvilinear fourth surface region, the second surface region and the fourth surface region being interconnected by an intermediate generally planar third surface region;wherein at least the third surface region comprises at least one groove disposed within the third surface region, the groove generally parallel to the direction of blood flow. 2. The tubular implantable medical device of claim 1, wherein the shear stress generated at the second surface region is between about 5 and 25 dynes/cm2. 3. The tubular implantable medical device of claim 1, wherein the second surface region includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm. 4. The tubular implantable medical device of claim 3, wherein the second surface region joins an abluminal surface to form an angle As, wherein the angle As is less than 90 degrees, wherein at least one surface includes a plurality of pores. 5. The tubular implantable medical device of claim 4, wherein second surface region joins the third surface region to an angle At, wherein the angle At is greater than 90 degrees. 6. The tubular implantable medical device of claim 5, wherein a length of the third surface region is less than a length of the second surface region. 7. The tubular implantable medical device of claim 6, wherein the abluminal surfaces further comprise a first abluminal surface joining a second abluminal surface and the second abluminal surface joining a third abluminal surface, whereby the third abluminal surface joins the fourth surface region to form a substantially hexagonal cross-section configuration of the structural member. 8. The tubular implantable medical device of claim 7, wherein the fourth surface region includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm. 9. The tubular implantable medical device of claim 8, wherein the fourth surface region joins the third abluminal surface to form an angle Ar, wherein the angle Ar is less than 90 degrees. 10. The tubular implantable medical device of claim 9, wherein fourth surface region joins the third surface region to an angle As, wherein the angle As is greater than 90 degrees. 11. The tubular implantable medical device of claim 10, wherein the length of the third surface region is less than a length of the fourth surface region. 12. The tubular implantable medical device of claim 11, wherein the second surface region and the fourth surface region include a plurality of geometric physiologically functional features including a focal adhesion point for affinity binding of endothelial cells. 13. The implantable medical device of claim 11, wherein the at least one groove is between 7 to 20 μm wide. 14. A method of forming a tubular implantable medical device having enhanced endothelial migration features, comprising: forming a tubular structure comprising of structural members, the tubular structure having a central longitudinal axis;forming the structural members to include a transverse cross-sectional profile comprising a first surface region joined to a concave curvilinear second surface region, the second surface region joined to a generally planar third surface region, the third surface region joined to a concave curvilinear fourth surface region, the fourth surface region joined to a fifth surface region, the fifth surface region joined to a sixth surface region; andwhereby the tubular implantable medical device includes at least one groove disposed across at least one of the second surface region, the third surface region, and the fourth surface region, the at least one groove being oriented generally parallel to the central longitudinal axis of the tubular structure. 15. The method of claim 14, further comprising forming the second surface region to include includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm. 16. The method of claim 15, further comprising joining the second surface region to the first surface region to form an angle As, wherein the angle As is less than 90 degrees, wherein at least one surface including a plurality of pores. 17. The method of claim 16, further comprising joining the second surface region to the third surface region at an angle At, wherein the angle At is greater than 90 degrees. 18. The method of claim 17, further comprising joining the first surface region to the second surface region, the second surface region to the third surface region, the third surface region to the fourth surface region, the fourth surface region to the fifth surface region, the fifth surface region to the sixth surface region to form a substantially hexagonal cross-section configuration of the structural member. 19. The method of claim 18, wherein the fourth surface region includes a radius curvature Rs, wherein Rs is between about 1 nm to about 75 mm. 20. The method of claim 19, further comprising joining the fourth surface region to the fifth surface region to form an angle Ar, wherein the angle Ar is less than 90 degrees.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (64)
Daniel Castro ; Steven Wu ; Kevin L. Woolbright ; Kurt W. Scheinpflug ; Syed F. A. Hossainy ; Li Chen, Apparatus and method for depositing a coating onto a surface of a prosthesis.
Georger ; Jr. Jacque H. (Springfield VA) Stenger David A. (Reston VA) Fare Thomas L. (Washington DC), Deep ultraviolet photolithographically defined ultra-thin films for selective cell adhesion and outgrowth and method of.
Julio C. Palmaz ; Eugene A. Sprague ; Cristina Simon ; Denes Marton ; Roger W. Wiseman ; Christopher E. Banas, Endoluminal device exhibiting improved endothelialization and method of manufacture thereof.
Palmaz, Julio C.; Sprague, Eugene A.; Simon, Cristina; Marton, Denes; Wiseman, Roger W.; Banas, Christopher E., Endoluminal device exhibiting improved endothelialization and method of manufacture thereof.
Palmaz, Julio C.; Boyle, Christopher T.; Banas, Christopher E.; Wiseman, Roger W.; Marton, Denes, Endoluminal implantable devices and method of making same.
Matsumoto Shigeharu,JPX ; Kikuchi Kazuo,JPX ; Yamasaki Masafumi,JPX ; Tang Qi,JPX ; Ogura Shigetaro,JPX, Method for forming a thin film of a composite metal compound and apparatus for carrying out the method.
Vallana Franco (Turin ITX) Arru Pietro (Turin ITX) Santi Marco (Settimo Torinese ITX), Prosthesis of polymeric material coated with biocompatible carbon.
Vallana Franco (Turin ITX) Arru Pietro (Turin ITX), Prosthetic device having a biocompatible carbon film thereon and a method of and apparatus for forming such device.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.