Prevention of premature gelling of delivery devices for pH dependent forming materials
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-025/14
A61M-025/00
A61B-017/00
출원번호
US-0724448
(2010-03-16)
등록번호
US-9445795
(2016-09-20)
발명자
/ 주소
Ohri, Rachit
Blaskovich, Phillip
출원인 / 주소
Confluent Surgical, Inc.
대리인 / 주소
Carter Deluca Farrell and Schmidt, LLP
인용정보
피인용 횟수 :
0인용 특허 :
37
초록▼
The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of
The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of a lumen of the device, in embodiments the tip of a spray applicator through which the material to be dispensed is expelled from the device, may be controlled to prevent premature gelling.
대표청구항▼
1. A delivery device comprising: at least one lumen;a means for aiding in expelling pH dependent forming materials from the lumen; andan opening configured to expel the pH dependent forming materials from the delivery device in vivo,wherein at least a portion of a surface of the delivery device comp
1. A delivery device comprising: at least one lumen;a means for aiding in expelling pH dependent forming materials from the lumen; andan opening configured to expel the pH dependent forming materials from the delivery device in vivo,wherein at least a portion of a surface of the delivery device comprises a charged polymer for modulating pH of a microenvironment near the surface thereby minimizing premature gelling of the pH dependent forming materials in contact with the surface and minimizing clogging of the delivery device. 2. The delivery device of claim 1, wherein the charged polymer comprises a coating on at least a portion of the surface of the lumen in contact with the materials. 3. The delivery device of claim 1, wherein the charged polymer possesses a negative charge. 4. The delivery device of claim 1, wherein the charged polymer possesses a positive charge. 5. The delivery device of claim 1, wherein the charged polymer is selected from the group consisting of 2-hydroxyethyl methacrylate, 2-acrylamido-2-methylpropane sulfonic acid, 3-methacryloylaminopropyl-trimethyl ammonium chloride, and combinations thereof. 6. The delivery device of claim 1, wherein the charged polymer comprises a positively charged copolymer of 3-methacryloylaminopropyl-trimethyl ammonium chloride with 2-hydroxyethyl methacrylate. 7. The delivery device of claim 1, wherein the charged polymer comprises a negatively charged copolymer of 2-acrylamido-2-methylpropane sulfonic acid with 2-hydroxyethyl methacrylate. 8. The delivery device of claim 1, wherein the charged polymer is selected from the group consisting of hydroxypropyl methylcellulose, methacrylic acid copolymers, and combinations thereof, in combination with an acid. 9. The delivery device of claim 8, wherein the charged polymer comprises a copolymer of methacrylic acid with ethyl acrylate. 10. The delivery device of claim 8, wherein the acid is selected from the group consisting of citric acid, fumaric acid, succinic acid, malic acid, and combinations thereof, present in an amount from about 0.1 percent by weight to about 10 percent by weight of the copolymer. 11. The delivery device of claim 1, wherein the delivery device further comprises: a manifold configured for operable engagement with at least a first and a second source of precursor of the material, the manifold including at least a first and second precursor channel therethrough; anda tip assembly,wherein the tip assembly is configured to receive a mixture comprising the at least first and second precursors prior to the mixture being expelled from an opening defined in a distal end of the tip assembly. 12. The delivery device of claim 11, wherein the tip assembly comprises a charged polymer. 13. The delivery device of claim 12, wherein the charged polymer comprises a coating on the tip assembly. 14. The delivery device of claim 11, wherein the device further comprises an elongated shaft extending distally from the manifold, the elongated shaft including at least a first and a second precursor lumen extending the length thereof, the at least first and second precursor lumens in fluid communication with the at least first and second precursor channels. 15. The delivery device of claim 14, wherein the tip assembly defines a first chamber, an intermediate chamber and a final chamber, wherein the first chamber is configured to receive a distal end of the elongated shaft, the intermediate chamber is configured to receive an insert, and the final chamber is configured to receive the at least partially mixed at least first and second precursors prior to the mixture being ejected from the opening defined in the distal end of the tip assembly. 16. The delivery device of claim 15, wherein the insert comprises silicone. 17. The delivery device of claim 14, wherein the manifold and elongated shaft are integrally formed. 18. The delivery device of claim 14, wherein the elongated shaft is flexible. 19. The delivery device of claim 14, wherein the elongated shaft comprises silicone. 20. The delivery device of claim 11, wherein the opening is configured to eject the mixture from the tip assembly as a spray. 21. The delivery device of claim 11, wherein the tip assembly comprises silicone. 22. The delivery device of claim 11, wherein the tip assembly is configured to flex during operation.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (37)
Sawhney,Amarpreet S., Adhesion barriers applicable by minimally invasive surgery and methods of use thereof.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Implants coated with collagen-polymer conjugates.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.