A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needl
A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module is initially in a locked state until attached to a drug delivery where a locking plate is moved to a triggering state. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted when the module is in the triggering state. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery.
대표청구항▼
1. A medicated module comprising: an outer housing including an upper hub having a first needle configured for attachment to a drug delivery device;a bypass housing inside the outer housing adapted to rotate and move proximally relative to the outer housing, the bypass housing including a reservoir
1. A medicated module comprising: an outer housing including an upper hub having a first needle configured for attachment to a drug delivery device;a bypass housing inside the outer housing adapted to rotate and move proximally relative to the outer housing, the bypass housing including a reservoir containing a medicament,a locking plate slidably coupled to the bypass housing and movable between a locked state prior to attachment of the drug delivery device to the upper hub and a triggerable state after attachment of the drug delivery device to the upper hub,wherein, when in the locked state, the locking plate engages the upper hub and prevents the bypass housing from rotating relative to the upper hub, andwherein, when in the triggerable state, the locking plate disengages the upper hub and the bypass housing is rotatable from a first angular position to a second angular position relative to the outer housing,wherein in the second angular position, the bypass housing translates axially relative to the outer housing and the reservoir is in fluid communication with the first needle. 2. A medicated module according to claim 1, wherein the bypass housing has a lower hub with a second needle located at the distal end of the bypass housing. 3. A medicated module according to claim 2, wherein a needle guard is coupled to the outer housing free to move axially, between defined constraints, within the outer housing and restrained rotationally with regard to the outer housing, wherein in an extended position, the needle guard covers the second needle. 4. A drug delivery system to deliver two or more medicaments operable through a single dispense interface, comprising, a primary reservoir of medicament containing at least one drug agent;a dose button operably connected to the primary reservoir of medicament;a single dispense interface configured for fluid communication with the primary reservoir; andthe medicated module of claim 1. 5. A drug delivery system to deliver two or more medicaments operable through a single dispense interface, comprising a drug delivery device and a medicated module of claim 1, the drug delivery device comprising a primary reservoir of medicament containing at least one drug agent; and a dose button operably connected to the primary reservoir of medicament. 6. A drug delivery system according to claim 5, wherein when the medicated module is attached to the drug delivery device fluid communication is made between the medicament in the primary reservoir and the first needle. 7. A drug delivery system according to claim 5, wherein when the medicated module is attached to the drug delivery device the locking plate is disengaged from the upper hub and axial movement of the needle guard compresses a biasing member exerting a force in the proximal direction on the lower hub and the bypass housing urging them both to move proximally, causing the needle cannula in the upper and lower hubs to become fluidly engaged with the medicament in the reservoir. 8. A drug delivery system according to claim 5, wherein the drug delivery device comprises at least one projection configured to engage the locking plate through the cutout. 9. A drug delivery system according to claim 8, wherein the at least one projection of the drug delivery device engages with a bearing surface of the locking plate causing the locking plate to be axially disengaged from the bypass housing and to be moved axially in distal direction allowing the locking plate to rotate relative to the upper hub. 10. A medicated module attachable to a drug delivery device, comprising, a) an outer housing having a proximal end, a distal end, and an inner surface, where the proximal end has an upper hub and a connector configured for attachment to a drug delivery device;b) a bypass housing inside the outer housing;c) a locking plate positioned between the proximal end of the bypass housing and the distal end of the upper hub wherein the locking plate is rotationally fixed to the bypass housing;d) a reservoir within the bypass housing comprising a medicament;e) a needle guard having inner and outer walls, where the inner wall engages the bypass housing to cause rotation of the bypass housing when the guard is moved axially, and where the outer wall is slidably engaged with the inner surface of the outer housing;f) a lower hub located at the distal end of the bypass housing; wherein the lower hub contains a double-ended needle cannula andg) a biasing member engaged between the needle guard and the lower hub,wherein the upper hub has a cutout that exposes a portion of the locking plate, whereinin a first position, the locking plate is in engagement with the upper hub and rotation of the bypass housing is prevented; and whereinin a second position, the locking plate is disengaged from the upper hub and the bypass housing is allowed to rotate relative to the outer housing. 11. The medicated module of claim 10, where the locking plate has a proximally projecting bearing surface exposed through the cutout. 12. The medicated module of claim 10, where the locking plate has a locking slot configured to engage with ribs on the bypass housing such that the locking plate is rotationally fixed to the bypass housing. 13. The medicated module of claim 10, where the locking plate has axial detent tabs configured to engage with detent engagement faces on the bypass housing to prevent distal movement of the locking plate. 14. The medicated module of claim 10, where the locking plate is engaged to the bypass housing through snap fasteners to prevent distal movement of the locking plate. 15. The medicated module of claim 10 where the locking plate has an outer housing contact face. 16. The medicated module of claim 15, where the locking plate has a first locked position wherein the outer housing contact face is engaged with the upper hub to prevent rotation of the bypass housing and a second unlocked position, wherein the outer housing contact face is disengaged from the upper hub to allow the bypass housing to rotate and move proximally. 17. The medicated module of claim 10, where the upper hub holds a double-ended needle cannula. 18. The medicated module of claim 10, wherein the biasing member is a compressed spring that exerts a force on the lower hub and the bypass housing. 19. The medicated module of claim 10, where the reservoir is a single molded component having an internal cavity with an integral flow distributor. 20. The medicated module of claim 10, where the reservoir contains a liquid medicament. 21. The medicated module of claim 10, where the medicament in the reservoir comprises a GLP-1. 22. The medicated module of claim 10 where the medicament in the reservoir comprises a premix of insulin and a GLP-1. 23. The medicated module of claim 10, wherein the locking plate has a locked state, where the locking plate constrains the bypass housing to the upper hub of the outer housing, and a triggerable state, wherein the locking plate has been moved axially and is no longer locked to the outer housing thereby allowing rotation of the bypass housing. 24. The medicated module of claim 10, wherein when the medicated module is attached to a drug delivery device, the locking plate is in the second position. 25. A drug delivery device comprising at least one projection configured to engage the locking plate through the cutout of the medicated module of claim 10.
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이 특허에 인용된 특허 (2)
Kirchhofer, Fritz; Gurtner, Thomas, Device for administering an injectable product.
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