초록 ▼

A method for the delivery of an oral care active agent comprising the following step: applying an active agent(s) between a target oral biological barrier and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return

A method for the delivery of an oral care active agent comprising the following step: applying an active agent(s) between a target oral biological barrier and a magnetic device comprising one or more pairs of displaced dipolar magnetic elements linked by a magnetic return wherein the magnetic return is orientated on the surfaces of the dipole pair distal to the biological barrier.

대표청구항 ▼

1. A method for the delivery by diamagnetic repulsion enhanced diffusion of an oral care active agent comprising: applying an active agent(s) between a target oral biological barrier and a magnetic device, the magnetic device comprising at least a first set of pairs of displaced dipolar magnetic ele

1. A method for the delivery by diamagnetic repulsion enhanced diffusion of an oral care active agent comprising: applying an active agent(s) between a target oral biological barrier and a magnetic device, the magnetic device comprising at least a first set of pairs of displaced dipolar magnetic elements and a second set of pairs of displaced dipolar magnetic elements,wherein the pairs of displaced dipolar magnetic elements have surfaces linked by a magnetic return,wherein the magnetic return is orientated on the surfaces of the pairs of displaced dipolar magnetic elements distal to the biological barrier,wherein a magnetic flux of each magnetic pole of the pairs of displaced dipolar magnetic elements is between 100 Gauss and 600 Gauss and wherein the poles in a spatial region are between 1.0 mm and 5.0 mm apart, andwherein the first set of pairs of displaced dipolar magnetic elements forms a layer and the second set of pairs of displaced dipolar magnetic elements forms a separate spatial layer relative to the first set of pairs of displaced dipolar magnetic elements, said spatial layers being arranged in parallel to the oral biological barrier,wherein the spatial layers are arranged such that the first spatial layer is stacked on the target oral biological barrier and the second spatial layer is stacked on top of the first layer more distal to the barrier than the first layer,wherein alignment of the first spatial layer comprising the first set of pairs of displaced dipolar magnetic elements is angularly offset between 1° and 90° relative to the second spatial layer comprising the second set of pairs of displaced dipolar magnetic elements, andwherein the angular offset of the first spatial layer comprising the first set of pairs of displaced dipolar magnetic elements to the second spatial layer comprising the second set of pairs of displaced dipolar magnetic elements results in multiple intersections of magnetic fields and multiple regions of magnetic flux gradient, andmoving in a reciprocal or rotational manner the magnetic device so that active agents in proximity to said device will be subject to alternating polarities of magnetic field and alternating magnetic flux gradients in response to said reciprocal or rotational movement. 2. The method according to claim 1 wherein the magnetic device includes an electronic or mechanical means for moving the magnetic device over the biological barrier. 3. The method according to claim 1 wherein the movement of the magnetic device has an oscillation frequency of 1 Hz to 5 Hz and the strength of the magnet field produced by each magnetic element is between 100 and 500 Gauss. 4. The method according to claim 1 wherein the movement of the magnetic device has an oscillation frequency of 100 to 8,000 Hz and the strength of the magnet field produced by each magnetic element is between 100 and 600 Gauss. 5. The method according to claim 1 wherein each pair of displaced dipolar magnetic elements is disposed at a repetition rate of between 2 and 10 dipolar pairs per centimeter. 6. The method according to claim 1 wherein each pair of displaced dipolar magnetic elements is disposed at a repetition rate of between 1.5 and 4 dipolar pairs per centimeter. 7. The method according to claim 1 wherein the magnetic flux of each magnetic pole is between 125 to 450 Gauss. 8. The method according to claim 1 wherein a delta magnetic flux between two adjacent poles of opposite polarity is between 100 Gauss and 2000 Gauss. 9. The method according to claim 8 wherein the delta magnetic flux between two adjacent poles of opposite polarity is 200 to 900 Gauss. 10. The method of claim 1 wherein the angular offset of the first spatial layer comprising the first set of pairs of displaced dipolar magnetic elements is at least 45° relative to the second spatial layer comprising the second set of pairs of displaced dipolar magnetic elements. 11. The method of claim 1 wherein the device is in the form of one of the following: a brush, a pad, a mouthguard, a dental splint, a roller applicator or a pen device. 12. The method of claim 1 wherein the active agent is applied to the oral biological barrier prior to application of the magnetic device. 13. The method of claim 1 wherein the active agent is applied to the magnetic device prior to application of the magnetic device to the oral biological barrier.