Provided is a flowable bioresorbable tissue dressing comprising a gas-forming porogen and a gel or gel-forming solution. Also provided is kits for preparing the above-described tissue dressing. Further provided are methods of treating a tissue site of a mammal with the above dressing. Also provided
Provided is a flowable bioresorbable tissue dressing comprising a gas-forming porogen and a gel or gel-forming solution. Also provided is kits for preparing the above-described tissue dressing. Further provided are methods of treating a tissue site of a mammal with the above dressing. Also provided is a reduced pressure delivery system for applying a reduced pressure tissue treatment to a tissue site.
대표청구항▼
1. A dressing for applying reduced-pressure treatment to a tissue site, comprising: a gas-forming porogen comprising a particle size for developing sufficient porosity for conducting reduced pressure;a bioresorbable microsphere; anda bioresorbable gel or a bioresorbable gel-forming solution in a mix
1. A dressing for applying reduced-pressure treatment to a tissue site, comprising: a gas-forming porogen comprising a particle size for developing sufficient porosity for conducting reduced pressure;a bioresorbable microsphere; anda bioresorbable gel or a bioresorbable gel-forming solution in a mixture with the gas-forming porogen and the bioresorbable microsphere;wherein the mixture is flowable, and after delivery to the tissue site, forms a scaffold comprising pores of at least 50 micrometers in diameter for delivering reduced pressure through the scaffold; andwherein the dressing is bioresorbable. 2. The dressing of claim 1, wherein the porogen is a mixture of an acid and a carbonate salt. 3. The dressing of claim 2, wherein the acid is citric acid. 4. The dressing of claim 2, wherein the carbonate salt is ammonium bicarbonate, sodium bicarbonate or calcium carbonate. 5. The dressing of claim 1, wherein the gel or gel-forming solution comprises collagen, gelatin, hyaluronic acid, or combinations thereof. 6. The dressing of claim 1, further comprising a non-gas forming porogen. 7. The dressing of claim 6, wherein the non-gas forming porogen is a salt. 8. The dressing of claim 7, wherein the salt is sodium chloride or potassium chloride. 9. The dressing of claim 6, wherein the non-gas forming porogen is a sugar. 10. The dressing of claim 1, wherein the bioresorbable microsphere comprises polylactide (PLA), polyglycolic acid (PLG), poly(lactide-co-glycolide) (PLGA), polyethylene glycol-PLA, PLA-polycaprolactone (PCL), a polyorthoester, a polyphosphazene, or a polyphosphoester. 11. The dressing of claim 1, further comprising a compound that adds stiffness to the dressing. 12. The dressing of claim 11, wherein the compound is calcium sulfate hemihydrate. 13. The dressing of claim 1, further comprising a bioactive agent. 14. The dressing of claim 13, wherein the bioactive agent is an antibiotic. 15. The dressing of claim 13, wherein the bioactive agent is a growth factor. 16. The dressing of claim 15, wherein the growth factor is growth hormone (GH), a bone morphogenetic protein (BMP), transforming growth factor-α(TGF-α), a TGF-β, a fibroblast growth factor (FGF), granulocyte-colony stimulating factor (G-CSF), granulocyte/macrophage colony stimulating factor (GMCSF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor/scatter factor (HGF/SF), an interleukin, tumor necrosis factor-α(TNF-α), or nerve growth factor (NGF). 17. The dressing of claim 1, further comprising a mammalian cell. 18. The dressing of claim 17, wherein the mammalian cell is an embryonic stem cell, an adult stem cell, an induced pluripotent stem cell, an epithelial cell, an endothelial cell, a mesenchymal cell, a muscle cell, a fibroblast, a chondrocyte, an adipocyte, or an osteocyte. 19. The dressing of claim 17, wherein the mammalian cell is a human cell. 20. The dressing of claim 1, wherein the pores of the scaffold are between approximately 50 micrometers and 1,500 micrometers in diameter. 21. The dressing of claim 1, wherein the pores of the scaffold are between approximately 100 micrometers and 500 micrometers in diameter. 22. A tissue dressing for applying reduced-pressure treatment to a tissue site, comprising: a gas-forming porogen comprising a particle size for developing sufficient porosity for conducting reduced pressure;a bioresorbable microsphere; anda gel or gel-forming solution in a mixture with the gas-forming porogen and the bioresorbable microsphere;wherein the mixture is flowable, and after delivery to the tissue site, forms a scaffold comprising pores of at least 50 micrometers in diameter for delivering reduced pressure through the scaffold. 23. The dressing of claim 22, wherein the porogen is a mixture of an acid and a carbonate salt. 24. The dressing of claim 23, wherein the acid is citric acid. 25. The dressing of claim 23, wherein the carbonate salt is ammonium bicarbonate, sodium bicarbonate or calcium carbonate. 26. The dressing of claim 22, wherein the gel or gel-forming solution comprises a polyacrylate, a poloxamer, a polyethylene glycol, chitosan, collagen, gelatin, hyaluronic acid, or combinations thereof. 27. The dressing of claim 22, wherein the gel or gel-forming solution comprises a combination of polyacrylate and chitosan. 28. The dressing of claim 22, wherein the gel or gel-forming solution is thermoreversible. 29. The dressing of claim 22, further comprising a non-gas forming porogen. 30. The dressing of claim 29, wherein the non-gas forming porogen is a salt. 31. The dressing of claim 30, wherein the salt is sodium chloride or potassium chloride. 32. The dressing of claim 29, wherein the non-gas forming porogen is a sugar. 33. The dressing of claim 22, wherein the bioresorbable microsphere comprises polylactide (PLA), polyglycolic acid (PLG), poly(lactide-co-glycolide) (PLGA), polyethylene glycol-PLA, PLA-polycaprolactone (PCL), a polyorthoester, a polyphosphazene, or a polyphosphoester. 34. The dressing of claim 22, further comprising a compound that adds stiffness to the dressing. 35. The dressing of claim 34, wherein the compound is calcium sulfate hemihydrate. 36. The dressing of claim 22, further comprising a bioactive agent. 37. The dressing of claim 36, wherein the bioactive agent is an antibiotic. 38. The dressing of claim 36, wherein the bioactive agent is a growth factor. 39. The dressing of claim 38, wherein the growth factor is growth hormone (GH), a bone morphogenetic protein (BMP), transforming growth factor-α(TGF-α), a TGF-β, a fibroblast growth factor (FGF), granulocyte-colony stimulating factor (G-CSF), granulocyte/macrophage colony stimulating factor (GMCSF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor/scatter factor (HGF/SF), an interleukin, tumor necrosis factor-α(TNF-α), or nerve growth factor (NGF). 40. The dressing of claim 22, further comprising a mammalian cell. 41. The dressing of claim 40, wherein the mammalian cell is an embryonic stem cell, an adult stem cell, an induced pluripotent stem cell, an epithelial cell, an endothelial cell, a mesenchymal cell, a muscle cell, a fibroblast, a chondrocyte, an adipocyte, or an osteocyte. 42. The dressing of claim 40, wherein the mammalian cell is a human cell. 43. The tissue dressing of claim 22, wherein the pores of the scaffold are between approximately 100 micrometers and 300 micrometers in diameter.
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